Erectile dysfunction(ED) is a common condition in men from 40 to 70 years of age,and during the last decades intensive research has highlighted clinical practice and public sectors.The development of Sildenafil,Vardenafil and Tadalafil have made the first class of agents capable of treating ED with convenient oral administration available.In the past years intracavernosal and intraurethral agents have been developed,but their clinical use was limited due to its invasiveness,and with high discontinuation rates.Gene therapy will be an effective method in future.

Idiopathic thrombocytopenic purpura (ITP),as a heterogeneous autoimmune disease,is the most common bleeding disorder,of which etiology and pathogenesis are still unclear. Health related quality of life are severely affected,especally in chronic patients . Studys on chronic idiopathic thrombocytopenic purpura pathogenesis ,both in China and abroad,have found that genetic factors may be involved in the occurrence and prognosis of the disease. The paper gives a review from the follow aspects,such as its risk factors,relationship between genetic polymorphisms or expression levels and chronic ITP susceptibility and seriousness,the role of epigenetic,researchs about chronic and refractory ITP,et al.

Objective To investigate the effects of different dose of edible liquor on cardiac structure and function in rats ,and explore its underlying mechanisms .Methods 54 male SD rats were randomly divided into saline group ,alcohol group ,liquor group , each group were further divided into low-,middle-and high-dose groups .After 12 weeks of feeding ,left ventricular pressure was de-termined ,and left ventricular pressure amplitude and indexes of HW /BW were calculated .Myocardial fibrosis was observed by Masson staining ,AngⅡ content of myocardial tissue were detected by ELISA ,and ACE and ACE2 mRNA expressions were detec-ted by RT-PCR ,respectively .Results Left ventricular pressure amplitude and HW/BW index were increased by both liquor and al-cohol .The myocardial cell turbidity ,degeneration ,hyperplasia of fibrous tissue change were gradually worsened ,and the AngⅡ con-tents and the ACEmRNA expressions of the myocardial tissue were also increased by both liquor and alcohol .The ACE2 mRNA ex-pression of the myocardial tissue were higher by low-dose liquor and alcohol ,while the ACE2 mRNA expression of the myocardial tissue were lower by middle-and high-dose liquor and alcohol .Conclusion Long-term alcohol consumption can damage the balance of cardiac ACE and ACE2 ,causing the increase of ACE ,AngⅡ and the decrease of ACE2 ,resulting in myocardial fibrosis ,whose degree is related to the amount of alcohol consumption and drinking history .

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia,which is rare in children.The treatment of APL mainly includes anthracycline-based chemotherapy,all-trans retinoic acid,and arsenic trioxide,which allow for complete remission,improve the long time survival rate and reduce related toxicity as well.About the optimized treatment,quick breakthroughs have already reached,not only at home in the 80's at the end of the 90's,but also abroad,like National Comprehensive Cancer Network of the United States in 2006-2013.This review summarizes the progress in diagnosis and treatment of children with APL.

[Objective] This paper sums up Professor Liu Ruifen's scholar thought and clinical experience in diagnosing and treating menopause reheating sweating symptoms.[Methods] From the aspects of the pathological mechanism, clinical manifestation and treatment based on syndrome differentiation of menopause reheating sweating symptoms, this paper sums up Professor Liu Ruifen's scholar thought and clinical experience in diagnosing and treating the disease. At the same time, this paper also sums up Professor Liu Ruifen's experience in Chinese materia medica and presctiptions and rehabilitation. [Re-sults] The pathogenesis of this disease is kidney yin deficiency, Chong and Ren disorders; nourishing yin combined with inhibing Yang to remove heat is the big iethod.[Conclusions]Professor Liu Ruifen's scholar thought and clinical experience in diagnosing and treating menopause reheating sweating symp-toms is effective and is trusted and welcomed by patients. Her thought and clinical experience are worth to extend and apply.

BACKGROUND: A great deal of free radicals can be induced,which results in peroxidation of the whole body. The antioxidant activity and the abilities of scavenging free radicals of proanthocyanidins(GSP) have been well documented,but related researches about the protective role in radiation damage were less reported.OBJECTIVE: To investigate the protective role of GSP combined with casein in 60Co-y radiation-induced peroxidative damage.DESIGN: Observing and comparative study based on animal model.SETTING: Nutrition Department of Daping Hospital Affiliated to the Third Military Medical College of Chinese PLA.MATERIALS: This study was carried out in the Third Institution of Field Operation Surgery, the Third Military Medical College of Chinese PLA.Eighty healthy Wistar rats,clearage,were adopted,ith weight from 180 to 220 g,half male and half female were adopted.METHODS: Rats were divided into four groups: normal control group,irradiation group,GSP group and GSP + casine group with 20 rats each. Rats in GSP group were fed routinely and supplemented with 1% GSP for 10days,which was replaced by 1% GSP and 5% casein. All rats except those of control group were exposed to whole-body 60Co-g amma-radiation at a dose of 7 Gy. Seven days later,6 survival rats randomly selected from each group were killed.MAIN OUTCOME MEASURES: The level of serum malondialdehyde (MDA), activities of serum superoxide dismutase(SOD),spleen index and the number of peripheral white blood cell(WBC).RESULTS: Serum MDA was obviously increased,accompanied by obviously attenuated SOD activity after irradiation; the level of MDA in both GSP group and combined group was found lower than that in irradiation group with statistical significance between them(P<0.01), the activity of SOD was significantly higher than that of irradiation group(P<0.01 ) . Markedly atrophic pathological change in spleen could be observed in irradiated rats,and meanwhile spleen index declined with the number of WBC notably decreased. But spleen index in both GSP group and combining group was markedly higher than irradiation group(P<0.05),and the same comparing result could also be found in the number of WBC(P<0.01 ).CONCLUSION: Peroxidative impairments could be obviously attenuated,and decrement of WBC could also be improved by single GSP or alternatively GSP combined with casein,with the latter showing greater effects in respect of improving immune function following irradiation,cellular chemical imbalance,and consequently the life quality.

Objective To investigate the effects of different tidal volume (V_T) on arterial oxygenation and intrapulmonary shunt(Q_S/Q_T) during one lung ventilation(OLV).Methods Sixty patients scheduled for selective lobectomy under left lateral decubitus position were randomly divided into groups of A,B and C with 20 cases each.After bronchial induction,two lung ventilation(TLV) was performed with V_T 10 ml/kg,frequency(f) 12 breaths per minute(BPM),ratio of inspiration to expiration(I: E) was 1:2 at first.During OLV,I: E was kept steady,V_T 6 ml/kg and f 20 BPM were chosed in group A,V_T8 ml/kg and f 15 BPM in group B,V_T 10ml/kg,f 12 BPM in group C.Blood gas analysis was determined before OLV (T_1) and at 10 min(T_2) ,20 min(T_3) ,and 30 min after OLV (T_4).Q_S/Q_T and lung complience(Cdyn) was calculated.Results OLV Compaired to T_1,PaO_2 and Cdyn were lower (P<0.05) and Q_S,Q_T and peak airway pression were increased (P<0.05).The decrease of PaO_2 was more in groups of A and C than that in group B(P<0.05).Conclusion During OLV,a better PaO_2.may be maintained with the ventilation parameters of V_T8 ml/kg and f 15 BPM with less increase in Q_S/Q_T and higher Cdyn.

Replacement therapy with plasma derived or recombinant F Ⅷ (rFⅧ) concentrates is only effective way to treat hemophilia A.Currently,the first,second and third generation rFⅧ are commercially available.Of the three products,the third generation rFⅧ products are best,because of no additional human or animal plasma proteins at any period.The use of rFⅧ concentrates has greatly improved the safety of replacement therapy in hemophilia A and reduced the risk of blood-borne pathogen transmission.In this article we review the current knowledge about the three rF Ⅷ concentrates,analyzing their main characteristic and their clinical hemostatic efficacy and safety.

OBJECTIVE:To discuss the significance of prescription analysis in Chinese drugs dispensing and to probe into the profound connotation of the dispensing of prescriptions of traditional Chinese medicines.METHODS:Take the basic theory of Chinese medicine as the basis,the importance of prescription analysis in the dispensing of traditional Chinese medicines were analyzed from aspects of the patients' clinical diagnosis,medication intention as well as the function and properties of drugs etc.RESULTS:8 essential factors were found to be involved in prescription analysis,which shed new light on the omnidirectional pharmacy care provided for patients.CONCLUSION:The key for Chinese drugs dispensing lies in the prescription analysis.

OBJECTIVE:To prepare hydrocortisone lotion and establish its quality control method. METHODS: The lotion was prepared with hydrocortisone, and the content of hydrocortisone was determined by ultravidet spectrophotometry. The stability of the prepartion and its skin stimulus were investigated as well. RESULTS: The preparation was colorless limpid liquid and up to the standard specified in Chinese Pharmacopeia (2005 Edition) in the related test. The linear range of hydrocortisone was 5.0～30 ?g?mL-1(r=0.999 0) and the average recovery was 100.09% (RSD=0.17%). After storing for 3 and 6 months, respectively, no obvious change was noted for the preparation. The skin stimulus experiment showed that it caused no side effects such as erythema on skin or edema etc. CONCLUSION: This lotion is simple in preparing process, and its quality is stable and controllable.