Objective To analyze the travoprost and brinzolamide for clinical effect of open-angle glaucoma and ocular hypertension in the treatment of persistent state.MethodsA total of 104 patients with open-angle glaucoma and ocular hypertension who were treated in our hospital from June 2014-2016 in June were randomly divided into control group and study group, each group had 52 cases.The control group were only treated by travoprost therapy, study group with travoprost combined with brinzolamide treatment, to study and analyze the efficacy of two groups.ResultsAfter treatment,the intraocular pressure improved,compared with before treatment,the difference was statistically significant(P<0.05).Visual acuity was significantly improved compared with before treatment,the difference was satistically significant(P<0.05).ConclusionFor open angle glaucoma and ocular hypertension patients combined with travoprost and brinzolamide treatment, patients can improve clinical curative effect, improve the visual acuity, it has practical value.

The myopic population is growing rapidly worldwide,the treatment of myopia become one of the hot spots in ophthalmology.Medicine therapy of myopia is now commonly used to slow down the progression of myopia,and it has already been the most expected one.Among all the drugs,the effect of muscarinic antagonists has been recognized at home and abroad.Muscarinic antagonists,according to their different M receptors,own different interventional approaches and therapeutic effects.Muscarinic antagonists,such include atropine,pirenzepine,tropicamide and cyclopentolate,their pharmacology and adverse effects are analyzed in order to explore their safety and efficacy and evaluate their clinical value.This paper reviewed these aspects of muscarinic antagonists and raise the discussion and prospect of muscarinic antagonists in the treatment of myopia.

Objective To investigate the methods of special departments nursing quality control in our hospital. Methods Through the establishment of nursing quality control standards of special departments, set up department quality control group, establish the three level nursing quality control systems and improve nursing care and quality control feedback mechanism,compare and contrast the quality control before and after the method application. Results Nursing quality of all special departments was significantly higher than before,there was significant difference;satisfaction degree of patients and doctors with nursing work significantly improved after the implementation of nursing quality control. Conclusions Nursing work can be scientific and standardized, satisfaction degree of patients and doctors can be improved through modifying nursing quality control methods of the special departments.

The book itself is well known in traditional Chinese culture of literature.It contains five chapters: Introspection,Social Intercourse,Deliberation,Leisure and Conspectus.There are 381 observations that lead us through paths as complex,absurd,and grotesque as life itself.Terse,humorous,witty,and above all,timely,this book offers a provocative and personal mix of Taoist,Buddhist,and Confucian understanding.And it embodies the inclusive cultural awareness of social intercourse,the thought of people-oriented educational management and the idea that harmony is above anything,which will lead the management of morality and ethics in higher medical institutions in China.

Objective To analyze the effect of combined use of povidone iodine and antifungal drugs in the treatment of fungal keratitis.Methods 96 cases of fungal keratitis patients suffering from the disease as the research object from March 2014 to March 2016 in our hospital,according to different treatment methods,they were divided into observation group and control group,48 cases in each group,control group received povidone iodine topical treatment,the observation group used povidone iodine and topical antifungal agents the treatment,the clinical efficacy of the two groups received.Results The total efficiency of the observation group was 97.9％higher than that of the control group 85.4％,the difference was statistically significant(χ2=4.909,P< 0.05);the visual acuity >0.05 share of the observation group was significantly higher than the control group,the difference was statistically significant(χ2=6.042,P< 0.05); There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion The combined use of povidone iodine and antifungal drugs in the treatment of fungal keratitis can produce a very significant therapeutic effect,effectively improve the visual acuity of patients,and has high application value.

Objective To observe the clinical effect of treating refractory ascites by intermittent cycle ascites reinfusion.Methods Having 30 refractory ascites patients of both chronic renal failure and maintenance hemodialysis(MHD),treating them 102 times by intermittent close ascites reinfusion and synchronous hemodialysis,having reinfusion ascites 3000～5000ml each time,checking the change of serum creatinine(Scr),blood urea nitrogen(Bun),and serum albumin before and after hemodialysis(HD) by blood-test,and observing their temperature,weight,belly size,blood pressure,and pulse before and after treatment.Results After treatment,all the patients feel well,have good appetite,and have less swollen belly.The average treatment is 3.2 times.The table shows the patients' weight,belly size,serum albumin,serum creatinie and blood urea nitrogen(Bun) before and after treatment.The difference is obviously distinctive(P

Objective: To analyze the risk factors for peri-procedural myocardial infarction (PMI) in patients with percutaneous coronary intervention (PCI) and to study the impact of CYP2C19 genotypes on PMI. Methods: A total of 283 coronary artery disease (CAD) patients received elective PCI were enrolled, the patients were with normal level of cTnI prior PCI, without adverse reaction post PCI and cTnI levels were re-examined at 24 hours after PCI. The patients were divided into 2 groups: PMI group,n=83 and Non-PMI group,n=200. CYP2C19 genotypes were detected by DNA microarray chip method and based on its result, the patients were classiifed into 3 genotypes: Extensive metabolism type, Intermediate metabolism type and Poor metabolism type. The patients with ADP inhibition rate ≤ 20% was deifned as heightened platelet reactivity (HPR) which was measured by thrombelastograph. Baseline clinical condition was compared between 2 groups and the impact of CYP2C19 genotypes with other risk factors for PMI occurrence were studied. Results: The occurrence rate of PMI was 29.3% (83/283); the age, gender, BMI, smoking, blood levels of TG, LDL-C and uric acid, history of hypertension and diabetes were similar between 2 groups,P>0.05. Compared with Non-PMI group, PMI group had more implanted stents (2.1 ± 0.9) vs (1.5 ± 0.6) and longer total length of stents 56 (36-71) mm vs 33 (23-51) mm, bothP<0.05; lower ADP inhibition rate (36.0 ± 29.8) % vs (43.9 ± 26.4) %,P=0.02 and higher HPR occurrence rate 39.8% vs 22.0%,P=0.01. The ratios of CYP2C19 genotypes of Extensive metabolism, Intermediate metabolism and Poor metabolism were 37.5%, 45.2% and 17.3% respectively, while PMI patients in each genotype were 21.7%, 29.7% and 44.9% respectively. Logistic regression analysis indicated that HPR (OR=2.18, 95% CI 1.19-4.01,P=0.02), total length of stents (OR=1.03, 95% CI 1.00-1.06,P=0.007) and CYP2C19 Poor metabolism genotype (OR=2.8, 95% CI 1.24-6.28,P=0.01) were the risk factors for PMI occurrence. Conclusion: HPR, total length of stents and CYP2C19 poor metabolism genotype were the risk factors of PMI occurrence, while poor metabolism genotype might be the most important endogenous reason for PMI occurrence.

Child ; Humans ; Lung Diseases, Interstitial ; diagnosis

Acupuncture Therapy ; methods ; Adult ; Aged ; Female ; Humans ; Intervertebral Disc Displacement ; therapy ; Male ; Middle Aged ; Young Adult

Breast cancer ranks among the most prevalent malignancies in women. Specific aspects of both breast cancer cells and the bone microenvironment contribute to the development of bone metastases. Breast cancers express chemokine receptors, integrins, cadherins, and bone-resorbing and bone-forming factors that contribute to the successful and preferential spread of tumor from breast to bone. Bone is rich in growth factors and cell types that make it a favorable environment for breast cancer cell growth. Once breast cancer cells enter the bone, breast cancer cells can secrete factors that act on bone cells and other cells within the bone, causing them to secrete factors that act on adjacent cancer cells. The steps in the metastatic cascade and the vicious cycle within bone offer unique targets for adjuvant treatments to treat and cure bone metastasis.