1.Medium-chain triglyceride ketogenic diet for drugresistant epilepsy in Taiwan: A prospective study in a single center
Yi-Shan Wang ; Meng-Ying Hsieh ; Po-Cheng Hung ; Min-Liang Chou ; Jainn-Jim Lin ; I-Jun Chou ; Wan-Ling Huang ; Huei-Shyong Wang ; Kuang-Lin Lin
Neurology Asia 2016;21(4):341-347
Objective: This study aimed to determine the efficacy of a medium-chain triglyceride ketogenic diet
on patients with drug-resistant epilepsy over a period of 1 year and 8 months. Methods: Patients
with refractory epilepsy on a medium-chain triglyceride ketogenic diet were prospectively enrolled.
Their clinical condition and the effectiveness of the ketogenic diet were followed-up every month for
1 year. Adverse events and the reasons for discontinuing the diet were recorded. Results: Fifty-three
patients (27 males and 26 females) were enrolled. At the end of the study, 21 patients remained on
the diet, 14 of whom were followed-up for 1 year. Among the 53 patients, 22.6% had a more than
50% reduction in seizure frequency, and 16.9% became seizure-free.
Conclusions: After a 1-year follow-up, the use of a medium-chain triglyceride ketogenic diet for patients
with drug-resistant epilepsy was found to be a safe and effective therapy, and may be considered to
bean alternative for patients with difficult-to-control seizures in children as well as young adults.
Epilepsy
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