0.05), complications (Fisher's exact probabilities in 22 table P=0.38) and the therapeutic effect (Fisher's exact probabilities in 22 table P=0.50) between two groups. A significant difference were found in associated with the time of bear partial burden (t=3.01, P

Gastric cancer is a common gastrointestinal cancer.With the incidence of cancer in the middle and proximal stomach is increasing year by year,radical total gastrectomy as a major operative method,is widely used in the treatment of gastric cancer.However,various surgical complications often occur after total gastrectomy,which affect patients' postoperative recovery and the quality of life.This article discussed the influential factors of surgical complications after total gastrectomy,and discussed the feasibility of applying Clavien-Dindo classification system to evaluate the severity of complications after total gastrectomy.

Objective To explore the correlation between blood uric acid/HDL-C ratio(UHR)and peripheral neuropathy(DPN)in T2DM.Methods A total of 127 T2DM patients admitted to the Endocrinology Department of Wujin Traditional Chinese Medicine Hospital in Changzhou City from August 2022 to August 2023 were selected.They were divided into a simple T2DM group(n=62)and a combined DPN group(DPN,n=65)based on whether or not they had DPN.Compare two groups of general information,biochemical indicators,and UHR.Results Compared with the T2DM group,DPN group DM course of disease,HbA1c,FPG,FIns,HOMA-IR,TG,vibration sensation threshold(VPT),hypersensitive C-reactive protein(hs-CRP),blood uric acid(SUA),and UHR(P＜0.05),HDL-C,tibial nerve motor nerve conduction velocity(mNCV),and superficial peroneal nerve sensory nerve conduction velocity (sNCV)decreased(P＜0. 05). Spearman correlation analysis showed that UHR was positively DM duration of disease,HbA1c,FPG,HOMA?IR,TG,VPT,hs?CRP,and SUA(P＜0. 05),negatively correlated with mNCV,sNCV,and HDL?C(P＜0. 05). Logistic regression analysis showed that UHR,DM duration, hs?CRP,and HbA1c were the influencing factors of DPN. Conclusion Elevated UHR is a influencing factor for the occurrence of DPN in T2DM patients and has good predictive value for DPN.

OBJECTIVE： To study the anti-inflammatory effect and its mechanism of the extract of Dcsmodium microphyllum， so as to provide experiment reference for further study of D. microphyllum. METHODS： Acute inflammatory model was established by xylene，glacial acetic acid and carrageenan. Using dexamethasone as positive control （0.005 g/kg）， inhibitory effects of intragastric different doses of the extract of D. microphyllum （50， 30， 15 g/kg） on xylene-induced ear swelling in normal mice and adrenalectomized mice， glacial acetic acid-induced permeability increasing of abdominal capillaries in normal mice， carrageenan-   induced paw swelling in normal mice and adrenalectomized mice were investigated. The levels of MDA， SOD and NO in the inflammatory tissue of toes of adrenalectomized mice were detected in carrageenan-induced inflammation model. Blank group was set for control （ig. equal volumn of water）. RESULTS： Compared with blank group， ear swelling degree of normal mice and adrenalectomized mice were decreased significantly in D. microphyllum extract high-dose and medium-dose groups while inhibitory rate of ear swelling was increased significantly； the permeability of abdominal capillaries of normal mice was significantly decreased in D. microphyllum extract groups； the swelling degree of toes in normal mice of D. microphyllum extract high-dose and middle-dose groups and adrenalectomized mice were significantly decreased while inhibitory rate of toe swelling was increased significantly （P＜0.05 or P＜0.01）. The levels of MDA and NO in the toe inflammatory site of adrenalectomized mice were decreased significantly in D. microphyllum extract high-dose and medium-dose groups， while the level of SOD was increased significantly （P＜0.05）. CONCLUSIONS： D. microphyllum extract can inhibit acute inflammation in mice significantly. Its anti-inflammatory mechanism is associated with decreasing MDA and NO while increasing SOD levels， and the anti-inflammatory effect does not depend on the hypothalamus-pituitary-adrenal axis system.