Objective To assess the effect of non-invasive positive pressure ventilation (NIPPV) in trea-ting acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated with type Ⅱ respiratory failure. Methods Sixty-two AECOPD patients complicated with type Ⅱ respiratory failure was randomly divided into two groups: treated group of 30 patients and control group of 32 patients. The control group was treated with reg-ular medicine, the treated group were treated with NIPPV additional to regular medicine. The pH value, PaO_2, PaCO_2 and lactic acid level in blood gas were measured before and after treatment. Results The level of PH, PaO_2, PaCO_2 and lactic acid at 24 hours after treatment in the treated groups were 7.36 (SD:0.05), 84.0 (SD :8.9) ,57.0 (SD:7.9) and 1.63 (SD:1.15) respectively, which were significantly different to those of the control group (7.34 [SD:0.03] ,53.0[SD:12.4] ,62.0[SD:9.4] and 2.54[SD:1.28] ,respectively) (P <0.05). Conclusinons NIPPV is effective in treating patients with AECOPD and type Ⅱ respiratory failture.

U.S.President Barack Obama proposed a precise medical initiative plan in early 2015 which caused widespread concern.According to the definition given by National Cancer Institute,precision medicine is the use of genetic information for the diagnosis or treatment of individual diseases.In the announcement gave by Barack Obama,one of the specific contents in precise medicine,the short-term goals include strengthen the use of precision medicine in cancer treatment,tumor therapy has thus identified as one of the most important concerns in precise medicine,which was given a great hope.As a result,research management personnel in cancer hospital should aware of the great importance of precise medical research,empower themselves by learning related ideas and models of precision medicine,explore the precise medical development related to the management of scientific research in the new theories,new methodologies,new mechanism and new models,in order to play an important role in scientific research management department in the hospital precise medical research to fulfill the coordination and management functions.

The National Natural Science Foundation of China is one of the most important fund channels for basic research in Peking University Cancer Hospital (hereinafter referred to as our hospital).Peer review was used for application review.In this article,the feedback opinions of applications from 2010 to 2014 for our hospital were categorized,summarized and analyzed.The common reasons of failure and corresponding measures were put forward to provide references for the applicants and scientific research managers for formulating relevant plicies.

Discipline construction is the core of the construction and development of hospital,the situation of discipline construction reflects the overall strength,academic position and core competitiveness of the hospital.The construction of clinical discipline mainly includes three contents:the construction of academic team,the determination of the subject direction,and the construction of the discipline platform.Scientific research is the main content of discipline construction.High level of research is the carrier of discipline construction.We have performed many management measures:improving the scientific management system,strengthening the dynamic management of the department,global planning,paying attention to personnel training and talent introduction,building reasonable talent echelon and advanced platform to create a good academic environment.According to these measures we have achieved fruitful results.

Based on the project data and SCI output data of 5431 projects supported by National Natural Science Foundation of China (NSFC) in oncology from 2008 to 2012,this paper took advantage of the Web of Science database,studied the number of papers published and the citations per paper of different research fields in oncology,different subcategories of projects,top 20 institutions funded by NSFC.Based on the study findings,we tried to make some suggestions for the funding agency,researchers,as well as research management personnel for increase the effectiveness of funding use,improve the administration work and policy-making concerns.

Cultivation of medical scientific research personnel is the driving force and source of the development of medicine.Powerful medical scientific research management would improve the overall level of hospital scientific research.Through the strengthening of discipline construction,the establishment of cooperation and communication platform,the implementation of an effective incentive mechanism,the improvement of research supporting conditions,the improvement of the quality of personnel management,the construction of scientific research management platform,we effectively enhanced the ability of scientific research personnel,and improved the level of scientific research in our hospital.

To inspire the research passion and improve the research capacity,we formulated the appraisal plan on research output of departments every five years.There are other annual awards for scientific research output.Then we can timely know the scientific progress of every department and the scientific research output has been improved.Some ideas of the plan should be reserved,such as,determination of assessment period,encouragement of collaboration,operational approaches,adjustable goals etc.The assessment criteria are supposed to be adjusted based on the classification of research capacity.

The factor that how the research funding is managed and used is very important for the progress and quality of research projects.With the continuous increase in the degree of supervision for the research fund,the attention to scientific research funding in hospital is also gradually raised.The problems of mismanaged and misuse research fund has been highlighted.The current study,based on the characteristics of medical research,comprehensively analyzed the existing problems of medical research funding in use and management from the point of view of research management.To solve these problems,we proposed suggestions and countermeasures to improve the use and management of research funding,and continued to improve the management of research funding.

Objective To investigate the hospital laboratory management mode.Methods We used literature review and comparative analysis to understand the different laboratory management mode,explore suitable operation mechanisms for hospital research and the development of hospital la boratory.Through a variety of measures to improve the efficiency and level of management,we tried to ensure the high efficiency and high quality operation of clinical laboratory,hospital science research,personnel training,discipline construction to provide quality services.Results There were two kinds of hospital laboratory management modes,which were centralized and decentralized management mode.Both management modes had advantages and disadvantages.We thought the centralized-decentralized binding mode was an ideal combination.Based of this mode,we implemented a number of initiatives and achieved significant results.Conclusions From the scale of hospital and its long-term development,centralized decentralized binding mode is a kind of ideal mode.

The quality and quantity of scientific research project are important indexes to evaluate the comprehensive scientific research strength of organizations.To improve the quality of grant and successful of application rate,we applied the circulation to scientific research management.We utilized fishbone analysis method to analyze the factors associated with successful rate of research projects and performed many countermeasures.According to the measurements,the quality of research project,management and successful rate has been continually improved.