1.Effects of total parenteral nutrition and enteral nutrition on pancreatic exocrine secretion and severe acute pancreatitis
Parenteral & Enteral Nutrition 1997;0(04):-
This review examines the effects of parenteral nutrition(PN) or enteral nutrition(EN) on pancreatic exocrine secretion and severe acute pancreatitis(SAP). There is no evidence that PN support in SAP affects the underlying disease process,but it may prevent the malnutrition and complications.In recent years,EN is considered to be used in that it preserves gut barrier function.PN,in contrast,may result in mucosal atrophy,bacterial translocation and increased rates of catheter related sepsis.The effects of EN on pancreatic exocrine secretion and natural course of SAP are discussed.The safety and feasibility of EN in SAP have been established. EN may even be superior to PN.Some patients,however,cannot tolerate enteral feeding and PN still has a role.
2.The effect of probiotics on the intestine microbial ecology
Parenteral & Enteral Nutrition 1997;0(04):-
The roles of the probiotics improving the intestine flora disturbance, protecting the intestine defense and barrier functions, and modulating the microbial balance are taking more attention in present years with important theoretical significance and clinical application value. We review the effect of probiotics on the intestinal microecology and its possible mechanisms.
3.Research advances of gut microbiota in diagnosis and treatment of colorectal cancer
International Journal of Surgery 2015;42(11):771-775
The association between colorectal cancer and gut microbiota imbalance has became a hot research topic along with the increase of its irevalance.In this article, we search for the potential specific carcinogenic strainand their metabolite markers in the development of colorectal cancer, with an attempt to provide an important basisfor early diagnosis and primary prevention of colorectal cancer, elucidate the potential roles and mechanisms of in-testinal microbioecological preparation and improve the management of colorectal cancer.
4.Influence of Lipofundin vs Intralipid on lipid and energy metabolism of surgical cirrhotic patients
Chinese Journal of General Surgery 2001;16(4):240-242
Objective To study the influence of Lipofundin vs Intralipid on lipid energy metabolism of cirrhotic patients undergoing surgery.Methods Twenty-five patients with liver disease were randomly assigned to two PN groups:LCT group(n=12) and MC/LCT group (n=13).Fat energy in group LCT was supplied by 20%-Intralipid,Group MCT/LCT was supplied by 20%-Lipofundin.All patients were on parenteral nutrition for 7 days.Intravenous fat tolerance test (IVFTT) was measured at pre-op,post-op d1、post-op d7.Carnitine (CNT) level in serum and urine,and AKBR were tested at the pre-op、post-op d1、d7.Results The elimination rate of the MCT was faster than that of LCT at pre-op and post-op d7,the elimination rate of LCT at post-op d1 was faster than that of at pre-op and post-op d7.Serum CNT increased in both groups,urine CNT markedly decreasd at postoperation,but in LCT group CNT was at lower level as compared with MCT group at post-op d7,P<0.05.AKBR was markedly decreased in both groups post-op,but at post-op d7,AKBR in MCT group was higher than in LCT group,P<0.01.Conclusions These results indicated that Lipofundin was an ideal energy source for the cirrhotic patients.
5.Progress of early diagnostic markers of intestinal ischemia injury
Chinese Journal of Clinical Nutrition 2010;18(6):369-374
Intestinal ischemia is a severe and life-threatening acute abdomen. Although its incidence is low,early diagnosis remains relatively difficult. The efficiencies of conventional laboratory biochemical tests are low. In recent years, many new markers for the early diagnosis of intestinal ischemia have been developed. In this article,we summarize their diagnostic efficiencies and relevant factors.
6.Probiotic-induced changes in intestinal cell signaling pathways
Chinese Journal of Clinical Nutrition 2012;20(2):112-116
Probiotics modulate the biological functions (and even cell apoptosis) of intestinal epithelial cells,intestinal macrophages,intestinal dendritic cells,and T cells via cell signaling pathways including nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways.Peroxisome proliferator-activated receptor γ (PPARγ) and heat shock protein (hsp) are targets for probiotics or their products.
7.Research advances in the association between gut microbiota imbalance and colorectal cancer
Chinese Journal of Clinical Nutrition 2013;21(4):229-234
Colorectal cancer (CRC) is a malignant digestive tract tumor resulted from genetic and environmental factors and can be accompanied by a series of gene mutations.The etiology of CRC,particularly the role of gut microbiota imbalance,has became a hot research topic along with the increase of its prevalance.In this article,we elucidate the potential roles and mechanisms of streptococcus gallolyticus,fusobacterium,Escherichia coli,Bacteroides fragilis,and helicobacter wlori in the development of CRC,with an attempt to further understand the functions of microbiota,search for possible specific carcinogenic strains,and improve the management of CRC.
8.Alteration of gut microbiota associated with colorectal cancer
Chinese Journal of Clinical Nutrition 2013;21(4):235-240
Human guts harbor abundant microbes that regulate many aspects of host physiology.However,bacterial imbalance or dysbiosis in the gut due to the dietary or environmental changes may cause colorectal cancer (CRC).Therefore,it is theoretically and clinically important to explore the correlation between possible carcinogenic bacteria and CRC and thus reduce CRC incidence by regulating intestinal microecological balance through the application of microecological preparations.
9.Nutrition and colorectal tumor
Parenteral & Enteral Nutrition 2001;8(1):59-63
The relationship of the nutritional and colorectal tumor was reviewed.The epidemiology of oral nutrition and colorectal tumor was investigated.The nutritional support in patients with colorectal tumor was discassed.The use of some amino acids and fatty acids might not only improve the hosts nutritional condition,but also serve as methods to treat tumor.
10.Values of histidine decarboxylase,intestinal fatty acid binding protein,and diamine oxidase for diagnosing intestinal mucosal injury in patients with intestinal obstruction
Chinese Journal of Clinical Nutrition 2011;19(2):67-73
Objective To investigate the clinical values of serum histidine decarboxylase(HDC),intestinal fatty acid binding protein(I-FABP),and diamine oxidase(DAO)for diagnosing intestinal mucosal injury (IMI)in patients with intestinal obstruction.Methods The expression levels of serum HDC,I-FABP,and DAO in 28 patients with strangulated intestinal obstruction,19 patients with simple intestinal obstruction,17 patients with acute simple appendicitis,and 20 healthy control were determined by enzyme-linked immunosorbent assay (ELISA)before clinical treatment,and then the areaa under receiver operating characteristic curves(AUC)of these diagnostic indicators were compared.In addition,the incidences of systemic inflammatory response syndrome (SIRS)and infectious complications were closely observed.The difference of the expressions of HDC,I-FABP,and DAO and their relationship with SIRS and infectious complications were compared among these patients and controls.Results The expression levels of serum HDC, I-FABP, and DAO were the highest in patients with strangulated intestinal obstruction (all P < 0.001), and the expression levels of these three indicators were significantly higher in patients with simple intestinal obstruction than in those with acute simple appendicitis or healthy controls (all P<0.05).The AUC of HDC (0.913) was significantly larger than that of I-FABP (0.877, P =0.000) and DAO (0.873, P = 0.000).When the cut-off value of HDC ≥31.00 ng/ml, the sensitivity, specificity, false negative rate, and false positive rate of HDC were 74.5% , 94.6% , 25.5% , and 5.4% , respectively,which were all better than those of I-FABP and DAO.There were significant differences of the incidence of SIRS ( P = 0.046) and abdominal infection (P = 0.027) among patients with strangulated intestinal obstruction, patients with simple intestinal obstruction, and patients with acute simple appendicitis, while lung infection showed no such significant difference (P = 0.728).The expression level of serum HDC was significantly higher in patients with strangulated intestinal obstruction who were also suffered from SIRS ( P = 0.000) or abdominal infection ( P =0.002) than that of uninfected patients.Meanwhile, the expression levels of serum I-FABP and DAO were significantly higher in the SIRS patients with strangulated intestinal obstruction than that of uninfected patients ( P = 0.027, P=0.017, respectively).The expression levels of HDC, I-FABP, and DAO were significantly correlated with the incideces of SIRS and abdominal infection ( all P < 0.05 ) , among which the level of HDC and the incidence of SIRS had the highest correlation (R = 0.608, P = 0.001).Conclusion HDC can be an effective indicator for diagnosing IMI in patients with intestinal obstruction.