Objective To investigate the clinical effects and significance of continuous intravenous infusion and sequential therapy in pneumonia in children.Methods 90 patients with pneumonia were randomly divided into the observation group and the control group,with 45 patients in each group,observation group received continuous intravenous infusion,the control group received sequential therapy.The expectoration and rales disappear time,chest X-ray and body temperature return to normal time,clinical efficacy were observed.Results The expectoration and rales disappear time,chest X-ray and body temperature return to normal time were longer than control group,which were significantly different (x2 =6.21,P ＜ 0.05),the total effective rate of observation group was 77.8％,the total effective rate of control group was 97.8％,the differences were statistically significant (t =3.58,4.62,6.18,7.01,all P ＜ 0.05).Conclusion The sequential therapy treatment pneumonia in children has better clinical effect,shorter hospital stay and worthy of clinical application.

Vascular calcification is a common pathology frequently occurred in the process of atherosclerosis ,hypertension , diabetes,chronic kidney disease,vascular injury and aging,resulting in an increased prevalence of cardiovascular events. Along with the social aging process,the incidence becomeshigher,andthis attract more attention. This review summarized a series of our works on vascular calcification in recent years ,including the update concept of vascular calcification ,recent classification and mechanism,and the confusion and hope in experimental and translational researches. This article aiming to promote further studies on the mechanisms and prevention of vascular calcification.

Objective:To establish a microfluidic chip system for immunoassay.Methods:We use direct-writing laser micromachining technology to fabricate microfluidic chip,establish microfluidic chemiluminescence immunoassay system based on superparamagnetic microbeads,and use this system to detect alpha-fetoprotein. Results:We can complete the analysis within 20 minutes with 5?l sample or reagent,the linear range was 1-800 ng/ml with average intra-assay and inter-assay precision at 6.3% and 7.8%,respectively and average recovery at 94.3%. Conclusion:The microfluidic chip system is a time-saving,cost-low and convenient method for AFP analysis.

Parpillary adenocarcinoma is the most common type of thyroid cancer with high probability of cervicel lymph node metastasis. Prophylactic neck dissection is not necessary for patients with clinical negative neck. Modified radical neck dissection is the standard for therapeutic neck dissection. The range of dissection remains controversial. Level Ⅰ is not included routinely, level Ⅱ is recommended. Dissection of level Ⅴ may cause malfunction of the neck and shoulder, clinical negative level Ⅴ for low-risk group can be avoided with close follow-up. Rountine central lymph node dissection tends to reduce the local recurrence. Selective neck dissection for thyroid parpillary adenocarcinoma needs more investigations.

Objective To explore the relationship between the clinical characteristics and laboratory examinations.Methods Retrospective analysis was performed on the clinical data in 172 patients diagnosed as infectious mononucleosis(IM)in our department recently.Results The onset rate was high from 3 to7 years old.The main clinical presentations included fever,neck lymphadenopathy,pharyngitis,hepatomegaly,and splenomegaly.Some patients accompanied with obvious sonorous.The occurring rate of the complications was 74.4%,especially deteriorated liver function was the most common,next came to the lung infection.The proportion of atypical lymphocytes raised in 73.3% cases.The positive rate of EBV-VCA-IGM was 65.1%.Myocardium ferment chart went up in 27.9% cases,Erythrocyte sedimentation rate increased fast in 61.6%,CRP gently got higher in 62.8%.However,the ratio of atypical lymphocyte and EBV-VCA-IGM positive or negative had little to do with the pathologic condition and complications in IM.Conclusions The clinical progress of most IM is benign and multiple organs can be involved with atypical clinical manifestations.Examination for atypical lymphocytes is an easy and effective means to screen IM.

BACKGROUND: Since non-coding RNAs maintain bone homeostasis through various pathways, applications of non-coding RNAs as bioactive molecules in bone tissue engineering for bone defect repair has become an increasing area of interest. OBJECTIVE: To introduce non-coding RNAs as bioactive molecules in bone tissue engineering. METHODS: A computer-based online search of Web of Science, PubMed, SpringerLink databases was performed by the first author between December 2018 and March 2019 using the search terms “bone tissue engineering, ncRNA (miRNA, siRNA or lncRNA), scaffold, drug delivery system” to retrieve papers published during 2004-2019. A total of 1754 papers were preliminarily retrieved, and 95 of them were eligible for final analysis. RESULTS AND CONCLUSION: Because non-coding RNAs play a key role in osteogenic differentiation, they can be used as important bioactive factors for bone tissue engineering. At present, bone tissue engineering repair methods based on non-coding RNA bioactive factors have become a research hotspot in bone defect repair. There are two major application strategies: (1) The non-coding RNA transcription within the seed cells is purposefully altered and combines with the bone tissue-engineered scaffold to promote bone defect repair. (2) a specifically designed bone engineered scaffold can controllably and purposefully alter the expression of non-coding RNA in the seed cells, which promotes bone defect repair. In addition, the function of more and more non-coding RNAs has been identified in the process of bone regeneration. This shows good application prospects of non-coding RNAs.

OBJECTIVE: To investigate the efficacy of endoscopic sinus surgery (ESS)-based multidisciplinary therapy for patients with chronic rhinosinusitis (CRS), nasal polyps and bronchial asthma. METHOD: The study included 32 patients with CRS, nasal polyps and bronchial asthma who received ESS, besides surgery, who also used glucocorticoid inhalation, nasal spray and nasal irrigation perioperatively. The evaluation of the treatment was performed 3 years post after ESS. RESULT: In the 32 cases treated with ESS, 19 cases were cured, 9 cases were improved, 4 cases were inefficient by the treatment. The cure rate was 87.5%. The asthma symptoms were improved in 9 patients (P < 0.01), compared to 2 before surgery. The numbers of patients with improved symptoms were increased from 2 before the surgery to 9 after the surgery. CONCLUSION As the main treatment, endoscopic si- nus surgery was effective on CRS with asthma.
Asthma ; surgery ; Chronic Disease ; Endoscopy ; Humans ; Nasal Lavage ; Nasal Polyps ; surgery ; Paranasal Sinuses ; Rhinitis ; surgery ; Sinusitis

In order to deal with huge work load of processing and reviewing applications,many personnels have been loaned from universities and research institutes to National Natural Science Foundation of China (NSFC) every year.This phenomenon has received much concern.In this paper,the features of NSFC loaned personnel model were analysed,and the necessity for and feasibility of improving the training function of NSFC by reforming current loaned personnel model were discussed.

Objective:To examine the correlation between the self-worth and mental health of middle school students .Methods:The Scale of Self-worth for Young Students and the SCL-90 were admemestered to a sample of 699 middle school students.Results:Analysis showed significant negative correlation between self-worth and the SCL-90 and mental health of middle school students,the SCL-90 scores of students with high self-worth were significantly different from that of students with low self-worth.Conclusion:The higher the self-worth of middle school students is ,the better their mental health is.

Objective To study the evaluation of rational use level of drugs in medical institutions.Methods According to the specific requirements of rational use of drugs in medical institutions,a criteria system is established.And a rational use of drugs evaluation model of medical institutions is to be built on the theory of fuzzy evaluation,group decision making and the analysis method of multi-index evaluation.Results Based on the fuzzy evaluation and group decision making,a rational use of drugs evaluation model of medical institutions is presented in the paper and one example is used to show the feasibility and the effectiveness of the proposed model.Conclusion The rational use of drugs evaluation model based on fuzzy evaluation and group decision making can effectively accomplish the evaluation of rational use of drugs of medical institutions,and build the foundation for improving the rational use of drugs of medical institutions and improving the level of universal health care.