OBJECTIVETo explore therapeutic effects of reconstructing coracoclavicular ligament for the treatment of Rockwood-III Acromioclavicular dislocation by palmaris longus muscle with polyester suture.

METHODSFrom August 2011 to November 2013,37 cases with Rockwood-III acromioclavicular dislocation were treated with reconstructing coracoclavicular ligament by palmaris longus muscle with polyester suture. Among patients, 24 were males and 13 were females, ranging the age from 19 to 46 years old, with an average of 32 years old. There were 11 cases on the left side and 26 cases on the right side. Twenty-nine cases were fresh dislocation and 8 cases were old dislocation. Blood loss, operative time were observed, and Karlsson evaltae standard were applied for assessing postoperative recovery of shoulder joint function.

RESULTSAll patients were followed up from 2.5 to 5 months with an average of 3.5 months. Operative time ranged from 52 to 98 (meaned 72) min, blood loss ranged from 50 to 180 (meaned 75) ml. All operative incision were healed at the satge I . According to Karlsson standard, 32 cases obtained excellent results and 5 cases were moderate.

CONCLUSIONFor Rockwood-III acromioclavicular dislocation,reconstructing coracoclavicular ligament by palmaris longus muscle with polyester suture has advantages of simple operation, and rapid recovery of shoulder joint function.

Acromioclavicular Joint ; injuries ; surgery ; Adolescent ; Adult ; Female ; Humans ; Ligaments, Articular ; surgery ; Male ; Middle Aged ; Reconstructive Surgical Procedures ; instrumentation ; Shoulder Dislocation ; surgery ; Sutures ; Young Adult

Objective to investigate the characteristics of externalizing problems behavior and related factors in new generation migrant workers so as to provide a decision making basis for consensus propaganda,psychological assistance and intervention.Methods A total of 1 340 new generation migrant workers(male 862,femal 478) were extracted from the gathering areas of mi grant workers in the three cities of Chongqing,Shenzhen and Hangzhou,the questionnaire survey and evaluation were performed by adopting the Youth Self-Report (YSR),Harter Self-Perception Profile(HSPP),Lum Emotional Availability of Parents (LEAP),Perceived Availability of Social Support Questionnaire(PASSQ) and Psychological Acculturation Scale(PAS).Results The tested externalizing problems were slightly higher than the non-clinical tested reasonable scoring range,the peer support had statistical difference between sexes(P＜ 0.01),the personal ability and comprehensive self value had significantly positive correlation (P ＜ 0.01),and both were negatively correlated to the externalizing behavior problems(P＜0.01),parents' emotional availability and support showed significantly negative correlation to externalizing behavior problems(P＜0.01),the working environment support was negatively related to externalizing behavior problems(P＜0.05).The prediction of personal effectiveness to externalizing prob lems behavior was obvious(P＜0.01),the social acceptance(P＜0.01) and overall self value(P＜0.01)were the predictive factors of externalizing problems behavior,and the work environmental support had the predictive effect on externalizing problems behavior (P＜0.05).Conclusion Personal ability,parents' emotional availability and support,work environmental support and social acceptance are correlated with externalizing behavior problems in new generation migrant workers.The overall self value,social accept ance,mother's emotional availability and parents' emotional support have significant prediction,while the work environmental support has a predictive effect on externalizing behavior problems.

AIDS has become a global disease,and a variety of drugs are used in the treatment of AIDS ,but the interindividual variabilities in efficacy and toxicity remain important limitations for the use of these drugs.Studies have shown genetic polymor-phism is the main reason for interindividual variabilities of drug reaction.In recent years,scholars focused on the pharmacog-enomics of anti-AIDS drugs and found that genetic polymor-phisms,in large part,determine the interindividual variabilities of the responese of these drugs.This paper reviews the research progress on pharmacogenomics of the four types of anti-AIDS drugs commonly used in China,including nucleoside reverse transcriptase inhibitors (NRTIs),non-nucleoside reverse tran-scriptase inhibitors (NNRTIs),protease inhibitors (PIs)and integrase inhibitors (raltegravir).

SHP-2 is one of the protein tyrosine phosphatases which plays a role in the progress of dephosphorylation in organ -isms, participating in many kinds of signal transduction pathways .The mutation of SHP-2 is associated with many kinds of malignant diseases .In recent years , scholars have found that SHP-2 is the key factor in osteoclastogenesis , playing a positive role in the progress of reversible phosphorylation of osteoclasts .The objective of this article is to review the molecular biological characteristics of SHP-2, th diseases associated with the mutation of SHP-2 and the effects of SHP-2 in regulation of osteoclastogenesis .

Objective To discuss Extracorporeal Membrane Oxygenation(ECMO) management method and effect during inter-hospital transport of potential cardiac death donors after cardiac death (DCD).Methods 8 potential donors after cardiac death with brain injury were supported by ECMO for inter-hospital transport.All donors were inserted Medtronic overall cannula into one side femoral artery and venous.The position of catheters were guided by ultrasound.The front-end of venous catheter located in the junction of atrium and inferior vena cava,meanwhile the front-end of artery catheter was below renal artery.100 IU/kg heparin was injected before inserting cannulas.Flow of ECMO maintained at 2.0～3.0 L/min,and oxygen flow was 2～3 L/min during ECMO supporting.When hemodynamics of potential donors were stable,patients were moved into ambulance with ECMO for inter-hospital transport.Results A total of 8 ECMO transports were performed for central circulatory collapse caused brain injury.Patients were previously cannulated and on ECMO prior to transport and transported a distance of more than 100 kilometer from our institution by ambulance.ECMO running times were 120 min,and operation process circulatory stable.Conclusion ECMO can ensure inter-hospital transport of potential donors after cardiac death safety.

Objective To investigate the value of CT and MRI in diagnosing facial nerve neuroma. Methods The CT and MRI findings of facial nerve neuroma proved by surgery and pathology in 6 cases were retrospectively analysed. Results Four of the six facial nerve neuroma only affected intratemporal segment of facial nerve (labyrinthine segment 1, tympanic segment 2, mastoid and tympanic segment 1), one involved the cerebellopontine angle(CPA) cistern, internal anditory canal(IAC) and intratemporal segment and last one involved both the intratemporal segment and the intraparotid gland segment. The imaging manifestations of the tumor depended on its location and extension. On CT, the tumors of intratemporal segment showed enlargement and destruction of facial nerve canal, soft tissue mass in the middle ear and /or in the mastoid, erosion of the aterior surface of the petrous bone at the level of the geniculate ganglion fossa, and extension to the middle cranial fossas and intraparotid gland. One neuroma arising from IAC and cisternal segments demonstrated a mass in the CPA, widening of the IAC, enlargement of the labyrinthine segment of the facial nerve canal, and extension to geniculate ganglion fossa by CT and MRI. Conclusion CT and MRI are accurate to describe the extent and location of facial nerve neuroma. CT is better to demonstrate the osseous destruction in detail, whereas enhanced MRI evaluates the tumor itself more accurately.

Animals ; Asthma ; drug therapy ; immunology ; metabolism ; physiopathology ; Child, Preschool ; Humans ; Infant ; Leukotrienes ; immunology ; metabolism ; pharmacology ; Respiratory Sounds ; drug effects ; immunology ; physiopathology

[ ABSTRACT] AIM:To observe the effects of long-term cigarette smoke exposure on pulmonary vascular remode-ling and the protein expression of transforming growth factor-β1 ( TGF-β1 ) in the rats, and to explore the mechanism. METHODS:SD rats (n=36) were randomly divided into control group, 2-week smoke exposure (S-2W) group and 12-week smoke exposure (S-12W) groups.HE staining andα-smooth muscle actin staining were performed to observe the pul-monary vascular remodeling.The protein expression of proliferating cell nuclear antigen ( PCNA) and TGF-β1 in the pulmo-nary arteries was determined by the method of immunohistochemistry.The mRNA expression of TGF-β1 in the pulmonary arteries was evaluated by RT-qPCR.RESULTS:Compared with control group, ratio of pulmonary vessel wall thickness to vessel diameter ( WT%) and percentage of muscularized vessels were significantly increased in S-2W group and S-12W group ( P<0.01) .Significant increases in the protein expression of PCNA and TGF-β1 in smoke exposure groups were ob-served compared with control group.There was significant difference between 2 model groups (P<0.01).Compared with control group, the mRNA expression of TGF-β1 in pulmonary artery walls obviously increased in smoke exposure groups. There was significantly difference between S-2W and S-12W groups (P<0.05).The mRNA expression of TGF-β1 was positively correlated with pulmonary vascular muscularization, WT% and the protein expression of PCNA.CONCLU-SION:Long-term cigarette smoke exposure results in pulmonary artery remodeling in rats.The possible mechanism is that cigarette smoking exposure induces the over-expression of TGF-β1 at mRNA level in pulmonary vessels and promotes the proliferation of pulmonary vascular smooth muscle cells in rats.

Metal sulfides are chemically attacked by Fe~ 3+ and H~+, resulting in the formation of elemental sulfur via polysulfides or thiosulfate pathway. Elemental sulfur may aggregate and even form a layer on the metal sulfide surface, which will inhibit leaching metals from the sulfides minerals. Elimination of inert elemental sulfur in a typical acidic environment can exclusively be by way of oxidation of acidophilic sulfur-oxidizing bacteria, such a way includes the attachment, transport and oxidation process of elemental sulfur by acidophilic sulfur-oxidizing bacteria. On the basis of analysis on the pertinent researches, the molecular mechanism of sulfur elimination by the acidophilic bacteria is far away from elucidated, and to attain that target, there are still much work to be done for elucidating the molecular mechanism on the attachment, transport and oxidation process of elemental sulfur by the acidophilic sulfur-oxidizing bacteria.