Allogeneic stem cell transplantation (allo-HSCT) is probably the only treatment for multiple myeloma (MM) with a curative potential.However,the application of allo-HSCT is limited by the high transplant-related mortality (TRM).Although the introduction of reduced intensity conditioning (RIC) has lowered the TRM associated with myeloablative conditioning,there is no improvement in survival of allo-RIC compared to autologous stem cell transplantation (auto-HSCT).New strategies are discussed with the aim of lowering transplant toxicity and boosting the graft-versus-myeloma effect,and these are urgently needed to make allo-RIC safer and more effective for myeloma patients.In this review,results from studies of allo-HSCT in MM are presented.

For transplantation-eligible multiple myeloma patients,induction treatment of triple drug regimens followed by the collection of hematopoietic stem cells is generally recommended.For transplantationeligible patients,high-dose melphalan remains the standard regimen.Consolidation after transplantation has shown an improvement in response rates.Maintenance therapy with bortezomib or lenalidomide (or both in very-high-risk patients) is a reasonable option for long-term disease control and improvement in overall survival.Application of new agents into therapy of multiple myeloma should result in improved outcomes and long-term disease control.

Up to now,one transketolase (TKT) and two transketolase-like genes (TKTL1 and TKTL2) have been identified in the human genome.People have conducted a series of basic and clinical researches of TKTL1 in malignant neoplasms since Coy found TKTL1 has a high expression of protein and gene levels in the malignant tumors in 2005.Although the biochemical and functional mechanism have not been clarified clearly,a positive role of TKTL1 in promoting tumorigenesis and tumor progression has been proved.

Objective To observe the change of door-to-needle time(DNT)and the intravenous thrombolysis rate by recombi-nant tissue plasminogen activator(rt-PA)in the patients with acute ischemic stroke (AIS)after establishing and perfecting the stroke green channel in our hospital.Methods A total of 3 990 patients with AIS in our hospital since 2010 were screened for the statistics on the number of the patients within the time window every year,conducting the analysis on the change trend of the annu-al intravenous thrombolysis rate and DNT.The change situation of DNT and the annual intravenous thrombolysis rate change were compared before the establishment of the stroke green channel and after the establishment and the continuous improvement of the stroke green channel.Results The proportion of AIS patients within the time window in our hospital was significantly lower than that in the domestic developed regions.The intravenous thrombolysis rate by rt-PA achieved the zero breakthrough since the estab-lishment of the stroke green channel in 2011.Along with the continuous improvement of the stroke green channel,the DNT median of the patients within the time window was reduced to 60 min in 2012 and 53.5 min in 2013,moreover the intravenous thrombolysis rate by rt-PA in the patients within the time window was increased from 0 in 2010 to 74.3% in 2013.Conclusion By gradually per-fecting the process of the stroke green channel and strengthening the cooperation of emergency,clinical laboratory and stroke team, DNT is reduced by a large margin and the intravenous thrombolysis rate is substantially increased,which indicates that establishing the perfecting and smooth stroke green channel in the serious pre-hospital delay areas is a necessary measure for increasing the in-travenous thrombolysis rate.

Objective:To explore the constitution characteristics in patients with vascular dementia(VaD),and to analysis the constitutional risk factor in VaD.Methods:This was a case-case control study.66 VaD patients and 51 stroke patients were selected by MMSE and Similarities test in WAIS-R、Blessed Behavior Scale.The diagnosis of VaD based on the DSM-Ⅳ and the NINDS-AIREN criteria、Hachinski Ischemia Scale、Cornell Scale of Depression in Dementia and the Clinical Dementia Rating.The stroke group was of MMSE≥28.The structured questionnaire of constitution was used to investigate and Wang Qi's method was used to constitution diagnose.Results: Yin Deficiency was the most common type in the VaD group and the stroke group(31.8% vs 45.1%),and the second was Phlegm-Damp(30.3% vs 35.3%).The frequencies of Yang Deficiency(15.2% vs 2%,P

Objective:To investigate the feedback regulation of transforming growth factor ?(TGF-?)to tumor necrosis factor-? converting enzyme.Methods:Reverse transcription polymerase chain reaction(RT-PCR)and immunochemistry were applied to detect TACE mRNA and protein in mice endometria of experiment group(TGF-? antibody was injected)and control group(saline was injected).Results:The expressions of TACE mRNA and protein in control group were higher than in experiment group.Conclusion: TGF-? could feedback on TACE expression in mice endometria and TACE-TGF-?-EGFR might one of the regulations during blastocyst implantation.

WNT signaling has been identified as one of the key signaling pathways in cancer,regulating cell growth,motility and differentiation.Because of its widespread activation in diverse human tumor diseases,the WNT pathway has gained considerable and growing interest in tumor research in recent years.

physiological criteria of seaman in hot enviroment on J506 ship during the voyage on the tropics was investigated in May, 1980. It was found that the 6 physiological heat criteria(body temperature, pulse rate, electrocardiogram, 3 hours-sweat, urinary salt and the quantity of 24 hours-urine)were within the tolerable limits at the ordinary works, and the cabin temperature was not more than 32℃ (WBGT).The body temperature and pulse rate elevated when the workload increased.When the ship transfer from the high latitudes to the low latitudes in a short time,it is advised to a heat acclimatization, otherwise, the heat damags even heat stroke would occur.The water and electrolytes of the seaman was maintained in balance on the voyage. No special supplement was needed.

The toxic effect of boron on Langerhans' islands was studied with insulin radio-immunoassay.The results were as follows : the blood sugar decreased and the level of blood insulin increased in the experimental group (taking boron 30mg/kg body weight per day for 96 days),compared to those in the control group,and a deviating phenomenon of excretion curves occurred.The results suggest that boron may have a toxic effect on ?-cells of Langerhans islands,which leads to an increase in blood insulin and a decrease in blood sugar,and Langerhans' islands may be relatively sensitive target organs.This study will be of some value in making the criterion of boron concentration in drinking water for short term consumption of troops in war.

Objective To establish a method for the dissolution determination of Boling dripping pills.Methods With 0.5 % sodium dodecylsulfate as solvents and rotation speed being 100 r/min,a RP-HPLC method was used to deter- mine the content of herpetin with the detection wavelength of 280 nm.Results Herpetin showed a good linear relationship with peak area in the range of 0.084～1.008?g(r=0.9999),and the average recovery was 99.18% and RSD was 2.15 %.The dissolution of three batches was 87.3 %～90.8 %.Conclusion This method is simple,accurate,reliable and suitable for the quality control of Boling dripping pills.