Objective To observe and explore the clinical curative effect and mechanism of four grinding soup oral liquid in treating pediatric indigestion.Methods 90 children with indigestion were randomly divided into control group and observation group,and 45 people in each group.Children in control group were given Pan Li ketone tablet and the observation group were given four grinding soup oral liquid to observe the clinical curative effect of the two groups and gastric emptying function,symptoms and plasma substance P,motilin levels of patients before and after treating.Results The clinical efficient of Pan Li ketone tablet and four grinding soup oral liquid were 70.0％ and 94.0％ respectively.The total effective rate of tgastric emptying of the control group and observation group of were 74.0％ and 80.0％,and there were no significant difference (P ＞ 0.10).The plasma substance P,and motilin content of the two groups before and after treatment had significant difference(P ＜ 0.05),but there was no significant difference (P ＞ 0.05) between group after treating; Conclusion Four Grinding Soup oral liquid is a safe and effective way in treating pediatric indigestion,and it can promote gastric emptying function,plasma substance P and motilin levels,which provides certain reference significance for treating clinical indigestion.

The periodontal regeneration is based on the proliferation and mult-differentiation of periodontal ligament cells.Thus,to find a method of enhancing the differentiation of periodontal ligament cells has been a hot point in studying periodontal disease.Many bioactive factors have important effects on the periodontal regeneration. Growth factors as bioactive factors have promotion effects on migration,growth,proliferation,differentiation,and protein synthesis.

Objective:To investigate the feedback regulation of transforming growth factor ?(TGF-?)to tumor necrosis factor-? converting enzyme.Methods:Reverse transcription polymerase chain reaction(RT-PCR)and immunochemistry were applied to detect TACE mRNA and protein in mice endometria of experiment group(TGF-? antibody was injected)and control group(saline was injected).Results:The expressions of TACE mRNA and protein in control group were higher than in experiment group.Conclusion: TGF-? could feedback on TACE expression in mice endometria and TACE-TGF-?-EGFR might one of the regulations during blastocyst implantation.

Objective To observe clinical efrect of treating angina pectoris with Shuxuening injection combined with western medicine.Methods 62 cases patients with angina pectoris were randomly recurited into a control group and a treatment group,The control group was treated with western medicine,and the treatment group was treated with Shuxuening injection based on the control group.The clinical effect was observed between the two groups.Results The clinical effect in the treatment group(83.9%)was significantly higher as compared to the control group(64.5%)(χ~2=2.352,P＜0.05).Conclusion The treatment of Shuxuening injection combined with western medicine on angina pectods is better than westem medicine only.

The plasticity of bone marrow stem cells is an important discovery in the field of stem cell research, which provides the possibility of bone marrow stem cells to be used for non-hematopoietic system diseases. There are rich data on bone marrow stem cells,which greatly accelerates the research on bone marrow stem cells plasticity. This article reviews the hot topics on plasticity of bone marrow stem cells.

Chronic Diseases have been the major public health problem since 1990 in China.This paper aims to explore the main results of the comprehensive sort of the North Carolina Project in Finland including the effects , key initiatives , intervention practices and successful experiences , and discusses the implications of Fanland experi-ence-based for the Chinese chronic disease intervention .The North Carolina Project shows that community-based in-terventions form an effective strategy for the prevention and control of chronic diseases .In order to respond effectively to the chronic disease challenges , the Chinese government should not only use community-based intervention strate-gies, but also implement a “comprehensive health policy”, creating a good and social atmosphere for the chronic dis-ease intervention .

Recent researches have achieved new progress in the function and signal transduction molecular mechanisms of erythropoietin (EPO).Previous studies confirmed that EPO is an independent angiogenic factor,especially in the development of retinopathy of prematurity (ROP).Recent research found that EPO protect the neurons as a neurotrophic factor.However,in proliferation stage as an angiogenic factor,EPO shares similarities with vascular endothelial growth factor ( VEGF ) in the early phase of diabetes.Besides,a recent study about effects of intravitreal EPO therapy for patients with chronic and progressive diabetic macular edema showed a short-term positive response.Here,the effects and molecular mechanisms of EPO/EPOR system in ischemic retinal disease were reviewed.

DNA methylation is a way of regulating gene expression of eukaryotes. DNA methylation in the regulation of normal cell development and cancer play an important role. There is evidence that in cancer patients compared with normal subjects,the former showed higher tumor suppressor gene methylation and cancer gene abnormality hypomethylation. In a variety of cancer types, related genes that can control cell cycle, proliferation, apoptosis ,metastasis,drug resistance and intracellular signal transduction exsist abnomal methylation.

Allogeneic stem cell transplantation (allo-HSCT) is probably the only treatment for multiple myeloma (MM) with a curative potential.However,the application of allo-HSCT is limited by the high transplant-related mortality (TRM).Although the introduction of reduced intensity conditioning (RIC) has lowered the TRM associated with myeloablative conditioning,there is no improvement in survival of allo-RIC compared to autologous stem cell transplantation (auto-HSCT).New strategies are discussed with the aim of lowering transplant toxicity and boosting the graft-versus-myeloma effect,and these are urgently needed to make allo-RIC safer and more effective for myeloma patients.In this review,results from studies of allo-HSCT in MM are presented.

Objective To observe the change of door-to-needle time(DNT)and the intravenous thrombolysis rate by recombi-nant tissue plasminogen activator(rt-PA)in the patients with acute ischemic stroke (AIS)after establishing and perfecting the stroke green channel in our hospital.Methods A total of 3 990 patients with AIS in our hospital since 2010 were screened for the statistics on the number of the patients within the time window every year,conducting the analysis on the change trend of the annu-al intravenous thrombolysis rate and DNT.The change situation of DNT and the annual intravenous thrombolysis rate change were compared before the establishment of the stroke green channel and after the establishment and the continuous improvement of the stroke green channel.Results The proportion of AIS patients within the time window in our hospital was significantly lower than that in the domestic developed regions.The intravenous thrombolysis rate by rt-PA achieved the zero breakthrough since the estab-lishment of the stroke green channel in 2011.Along with the continuous improvement of the stroke green channel,the DNT median of the patients within the time window was reduced to 60 min in 2012 and 53.5 min in 2013,moreover the intravenous thrombolysis rate by rt-PA in the patients within the time window was increased from 0 in 2010 to 74.3% in 2013.Conclusion By gradually per-fecting the process of the stroke green channel and strengthening the cooperation of emergency,clinical laboratory and stroke team, DNT is reduced by a large margin and the intravenous thrombolysis rate is substantially increased,which indicates that establishing the perfecting and smooth stroke green channel in the serious pre-hospital delay areas is a necessary measure for increasing the in-travenous thrombolysis rate.