Objective To analyze the clinical effect of combination therapy of somatidine on colorectal cancer with intestinal obstruction. Methods 120 patients with colorectal cancer complicated with intestinal obstruction who were treated with Yujiang County Hospital of Zhejiang Province from November 2016 to May 2017 were selected as the subjects of this study and divided into observation group by dynamic random color ball extraction method And control group. The rats in the control group were given stage I colonic resection and anastomosis. The observation group was treated with somatanine combined with stage I colonic resection and anastomosis. The differences of the indexes and complication were compared between the two groups. Results There was no significant difference in the operation time between the two groups (3.01 ± 0.41) days and the hospitalization time (10.11 ± 1.21) days in the observation group, and the time of operation was significantly higher than that of the control group (5.41 ± 0.84) days, the hospitalization time was (16.33 ± 2.05) days, the number of complications occurred in 10 cases, the difference was more than that in the control group Significantly(P<0.05). Conclusion Si Tanning combined with surgical treatment of colorectal cancer with intestinal obstruction has a certain value.