1.Study on the relationship between polymorphism sites of IRF5 and SLE patients in Shandong Han population
Weiqing SONG ; Huahui LI ; Huabo CHEN ; Jiangshui YUAN ; Xiaojie YIN
Chinese Journal of Microbiology and Immunology 2009;29(5):416-419
Objective To investigate two single nucleotide polymorphism sites of IRF5 and to de-tect their relationship with SLE in a population from Shandong province. Methods The polymorphisms (rs2004640 G/T,rs10954213 G/A) were detected with PCR-RFLP in 92 eases of SLE and 88 healthy con-trols. The genotype and allele frequencies were calculated and analyzed. Results The genotype frequencies Of GG, GT and TT in rs2004640 site in SLE were 0. 198, 0.521 and 0.281, respectively. The difference was significant between SLE and centrol (X2 = 8.73, P < 0.05). The genotype frequencies of GG, GA and AA in rs10954213 site in SLE were 0. 318, 0. 409 and 0.273, respectively. The differenee was significant between SLE and control (X2 = 6. 36, P < 0. 05). Conclusion The polymorphism of rs2004640, rs10954213 in IRF5 may be associated with SLE in the population of Han nationality from Shandong province of China.
2.mRNA expression of interferon regulatory factor 5 and Toll like receptor-9 in patients with systemic lupus erythematosus
Weiqing SONG ; Huahui LI ; Huabo CHEN ; Jiangshui YUAN ; Xiaojie YIN
Chinese Journal of Dermatology 2009;42(9):613-615
h may play a role in the pathogenesis of SLE.
Result Analysis
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