Gilbert's syndrome is a congenital,nonhemolytic,unconjugated hyperbilirubinemia.The intermittent mild jaundice is its clinical characteristic.The pathogenesis of the disease is the gene mutation of the isoenzyme which encoding the UDP-glucuronosyltransferase (UGT1A1).The gene mutation can affect glucuronic acidation of drugs.Therapeutic dose can cause unexpected toxicity.It is very important to detect the gene mutation of UGT1A1 for diagnosis,treatment and genetic counseling of Gilbert's syndrome.

This paper summarised the pharmacology studies and evaluation of clinical application on Shexiangbaoxin pills, for doctors' reference.

AIM:To investigate the effect of intravitreal ranibizumab ( IVR) in the treatment of exudative age-related macular degeneration ( AMD ) with serous retinal pigment epithelium detachment ( SPED) in elderly patients. ·METHODS: We Selected 60 elderly patients ( 60 eyes ) with AMD and SPED in our hospital from February 2015 to February 2016, treated by intravitreal injection of ranibizumab. The best corrected visual acuity ( BCVA ) , PED height and volume, central fovea thickness ( CFT ) and aqueous humor vascular endothelial growth factor ( VEGF) were measured before and after treatment. ·RESULTS:The BCVA of patients with after treatment for 1, 3 and 6mo were 0. 6 ± 0. 1, 0. 4 ± 0. 1 and 0. 3 ± 0. 1, and were significantly higher than those before treatment ( P<0. 05). At 1, 3 and 6mo after treatment PED height and volume were significantly lower than before treatment (P<0. 05), of which 6mo after the treatment PED height and volume were 240. 02 ± 35. 10μm and 0. 310 ± 0. 120mm3 . At 6mo after treatment CFT was 290. 02±33. 10μm, significantly lower than before and 1mo after treatment (P<0. 05). At 1, 3 and 6mo after treatment VEGF were lower than those before treatment (P<0. 05), in which 6mo after the treatment aqueous humor VEGF was 149. 11 ± 28. 89pg/mL. No endophthalmitis, uveitis and so on adverse reactions were observed during treatment. ·CONCLUSION:IVR has a good effect in the treatment of exudative AMD in elderly patients with serous PED, which can effectively improve the visual acuity of patients, reduce the height and volume of PED and the concentration of VEGF in aqueous humor, and it is safe and reliable.

Aged ; Carcinoma, Squamous Cell ; metabolism ; pathology ; surgery ; Humans ; Immunohistochemistry ; Keratins ; metabolism ; Ki-67 Antigen ; metabolism ; Male ; Pancreas ; metabolism ; pathology ; Pancreatic Neoplasms ; metabolism ; pathology ; surgery ; Pancreaticoduodenectomy

Character Repertoires are supported by DICOM to encode Characters in different languages, in which UTF-8 and GB18030 are for Chinese characters. Each of them can replace Acquiesced Character Repertoire in Attribute Specific Character Set so that Chinese characters can be encoded in data elements. Utility programs compatible with DICOM are also required to support UTF-8 or GB 18030 for unerring representation and encoding.

Objective To determine the content of calycosin-7-?-O-D-glucopyranpside in Danggui Buxie Dropping Pills.Methods HPLC method was used. The chromatographic column was YMC-C18(150?4.6 mm, 5 ?m), the mobile phase was methanol and water(40 ∶60), the detection wavelenth was 235 nm, column temperature at 20 ℃and flow rate was 1.0mL/min.Results Calycosin-7-?-O-D-glucopyranpside was separated well with other components and was in good linearity in the range of 0.02～0.80 ?g. The average recovery was 97.62 %and RSD=1.06 %.Conclusion The method is rapid and accurate and can be used for quality control of Danggui Buxie Dropping Pills.

In the light of sociological and psychological theories, the authors reflect from the perspectives of social politics, economy, culture, psychology and law on the current situation of the physician-patient relationship, the causes and lessonss. They argue that the current situation of the worsening physician-patient relationship is worrisome, its causes are multifarious, and channels for improvement ought to be as wide as possible. They hold that there is still a long way to go to improve the situation, efforts ought to be made by the whole society and humane medical services are indispensable.

Air Pollutants, Occupational ; Fuzzy Logic ; Occupational Exposure ; prevention & control ; Occupational Health Services ; Paint ; Risk Assessment

ObjectiveTo observe effects of Fentanyl Transdermal System and Sanlitong on pain of hemorrhoids patients after operation of micro wave heating among tissue.Methods60 hemorrhoids patient whom were treated by micro wave heating among tissue were randomly divided into group A and group B. Patients of group A had Fentanyl Transdermal System affixed on navel position. Patients of group B taken Sanlitong. Effects of two groups were estimated with McGill Questionnaire.ResultsThere was a significant difference between pain scores of two groups in one or two weeks after hemorrhoids operation. The ease pain effect of Fentanyl Transdermal System was better than that of Sanlitong tablet within two weeks after operation.ConclusionThe Fentanyl Transdermal System is a safe, simple and better effect medicament type for ease the pain when treating hemorrhoids with method of micro wave heating among tissue.