Objective:To compare the efficacy between nateglinide and repaglinide in improving type 2 diabetes pancreatic ? cell function.Methods:A double-blind,randomized clinical study was introduced to 46 patients with type 2 diabetes mellitus who were administrated with nateglinide or repaglinide for 12 weeks.Both in the 0 week and the 12th week concentration of the serum insulin,C-peptide and blood glucose,as well as plasma HbA 1c concentration,were measured respectively at preprandial 0 min and postprandial 30,60,120min.Homa-?index,insulin response to glucose(IRG)and the ratio of the area under curve between insulin and glucose(AUCi/AUCg)were computed for statistical analysis.Results:Compared with 0 week,the levels of blood glucose and plasma HbA 1c all dropped in both groups with statistical significance(P

Blood Vessels ; injuries ; Humans ; Iatrogenic Disease ; prevention & control ; Vascular Diseases ; etiology ; prevention & control

AIM: To study the clinical effects of using sodium hyaluronate in the glaucoma trabeculectomy. ·METHODS: Totally 46 patients were included in our research and they were divided into two groups. In the study group (23 cases 23 eyes), we used slice with MMC of 0. 4mg/mL in trabeculectomy. Before the conjunctiva flap was sewed, a small amount of sodium hyaluronate was injected into the space under scleral flap and the anterior chamber. In control group ( 23 cases 23 eyes ) , we only used MMC. After trabeculetomy, shallow anterior chambe formation, intraocular pressure, corneal endothelial injury and the formation of filter-bubble were observed in long term. ·RESULTS:IOP of study group at 1d after operation was higher than that of control group ( P<0. 05 ), but not significant different at 3d, 1 and 6mo after operation(P>0. 05). At 3d after operation, visual acuity decreased in 2 eyes (9%) of study group, 8 eyes (35%) in control group with significant different ( P = 0. 035 ). At 6mo after operation, visual acuity decreased in 0 of study group, 5 eyes (22%) in control group with significant different (P=0. 025 ). The differences on the occurrence of shallow anterior chamber at 7d after operation, formation of filter-bubble at 6mo after operation and corneal endothelial count were significant (P<0. 05). There were less postoperative complications in study group than in control group. ·CONCLUSION: Using sodium hyaluronate combined with MMC in trabeculectomy can greatly prevent the formation of shallow anterior chamber, filter-bubble scarring, and corneal endothelium dropout, make it possible to a safer surgery and a better outcome.

Objective To study the new anticoagulants, felling shaaban joint care used in joint replacement for prevention of deep vein thrombosis.MethodsThe Second People's Hospital of Chengdu orthopaedics in March 2016 to March 2017 were hospitalized patients with knee joint replacement and total hip replacement of the 158 patients, according to the stochastic indicator method were randomly divided into observation group and control group, 79 cases in each group, the observation group received new anticoagulants, cutting class joint care, the control group accepted low molecular weight heparin calcium in combination with care.Observe two groups of treatment of deep vein thrombosis prevention effect and adverse reactions.ResultsCompared with control group, the observation group with lower incidence of DVT and difference comparing the two groups have statistical significance (P<0.05).Observation group compared with control group, PT, APTT, preoperative and postoperative 2 day, five days did not have obvious difference, no statistical significance.Observation group compared with control group, subcutaneous ecchymosis, incision hematoma bleeding had no obvious difference).ConclusionThe laval shaaban joint care to prevent deep venous thrombosis after artificial joint replacement effect of low molecular weight heparin calcium is better, and coagulation function effect is small.

Multiple organ dysfunction syndrome(MODS) is an important area of critical medicine study.Establishing a suitable animal model is one of the important manner in the study.This article has reviewed the choice of animal,assessment of model and the method of making model.

Arteriosclerosis Obliterans ; surgery ; Humans ; Lower Extremity

Adult ; Amides ; adverse effects ; Benzene ; adverse effects ; Burns, Chemical ; pathology ; therapy ; Female ; Humans ; Male ; Middle Aged ; Nitro Compounds ; adverse effects ; Young Adult

Medical postgraduates are the future core force of clinical diagnosis and treatment,scientific research,education and sanitary administration.Therefore,to cultivate qualified professionals,the key of contemporary medical postgraduate education is to pay more attention to comprehensive quality training in order to make students adapt to the continuous development of society and medical model.The First Clinical College in Wuhan University has implemented the hospital administration internship in combination with social needs and explored the education model of contemporary medical students with comprehensive quality.

Humans ; Laparoscopy ; Proctectomy ; Quality of Life ; Rectal Neoplasms/surgery* ; Rectum/surgery* ; Transanal Endoscopic Surgery