AlM: To compare the impact of different thickness of corneal cap design on small incision lenticule extraction ( SMlLE) operation.METHODS: Forty-six cases of myopia patients ( 92 eyes) intends to SMlLE operation in our hospital were collected , and were randomly divided into 2 groups:corneal cap thickness design for 110μm in group A and 120μm in group B. Other operation parameters designs were consistent. All patients were surgeried by the same surgeon. The incidence of opaque bubble layer ( OBL ) , the ratio of difficult separation of lens, uncorrected visual acuity ( UCVA ) of each time points, and spherical equivalent ( SE) were compared.RESULTS: lntraoperative OBL incidence rate of 110μm group was higher than that of 120μm group with significant difference between the two group (P<0. 05). the ratio of difficult separation of lens was significantly different between the two groups: 110μm group was higher than in 120μm group (P<0. 05). The UCVA in the 120μm group was better than that in the 110μm group at postoperative 1 and 7d. But with the passage of time, postoperative 1, 3, and 6mo of UCVA of 2 groups was similar, showed no significant difference (P>0. 05). SE were compared at 7d and 6mo after operation, showed no significant difference (P>0. 05)CONCLUSlON: Compared with 120μm group, corneal cap design SMlLE operation in 110μm group are more prone to OBL and difficult separation of lens, thus affects UCVA and postoperative recovery rate. There is no significant difference in long-term UCVA.

Plasma aldosterene/renin ratio (ARR) is a sensitive screening test and parameter for primary aldosteronism(PA).The use of ARR leads to a marked increase in the detection rate of PA in the hypertensive population.However,ARR remains a nonstandardized test,and the cutoff value of ARR used in the different studies is varied.Further and systematical studies are needed to improve the accuracy of the test.

Child ; Child Health Services ; trends ; Delivery of Health Care ; organization & administration ; Education, Medical ; Hospitals, Pediatric ; economics ; organization & administration ; Humans ; Pediatrics ; trends ; Specialization ; Urban Population

To investigate the apoptotic effect of free fatty acids (FFAs) on human ovary granulosa cells, the granulosa cells were treated with FFAs in various concentrations for three days, and then the cell viability was determined by trypan blue exclusion method. DNA fragmentation was examined by DNA ladder formation and Annexin V GFP/PI staining of the cells. We also determined if the apoptotic effect of saturated FFAs was mediated by their acly CoA metabolites and measured the expression of apoptosis related genes, Bcl 2 and Bax by Western blot. The results indicated that saturated FFAs induced apoptosis of granulosa cell by their acly CoA metabolites in a dose dependent manner, and led to the down regulation of Bcl 2 and the up regulation of Bax. It is concluded that saturated FFAs can induce apoptosis of human ovary granulosa cells, suggesting that the sexual disorder of obese and insulin resistant women is related to it.

Objective: To investigate connective tissue growth factor (CTGF) mRNA and protein expression levels in thyroid tissues and analyze their relation to clinical and pathological features of thyroid cancer. Methods: This study quantified CTGF mRNA and protein expression levels in 72 pairs of thyroid papillary carcinoma, 45 pairs of thyroid adenoma and 71 pairs of simple goiter and their matched thyroid tissues using real-time fluorogentic quantitative PCR (RFQ-PCR) and immunohistochemistry staining and analyze their relationship with clinicopathological parameters. Results: RFQ-PCR showed that the CTGF mRNA expression was significantly higher in 59.7% (43 of 72) thyroid papillary carcinoma tissues than that in the matched thyroid tissues; CTGF mRNA expression was significantly lower in 66.7% (30/45) thyroid adenoma and 88.7% (63/71) simple goiter tissues than that in their matched normal thyroid tissues, respectively. The result of immunohistochemical staining was consistent with that of RFQ-PCR. Logistic regression showed that female, lymph node metastasis, higher pathological grade, bigger tumor volume and elevated TSH levels were risk factors of higher expression of CTGF mRNA in thyroid papillary carcinoma; female, higher pathological grade and higher TSH level were risk factors of higher expression of CTGF protein in thyroid papillary carcinoma; both bigger tumor volume and lower FT4 level were risk factors of higher expression of CTGF mRNA and protein in thyroid adenoma. Both male, lower FT4 and TSH level were risk factors of higher expression of CTGF mRNA and protein in simple goiter. Conclusion: Over-expression of CTGF was important in the tumorigenesis and progression of thyroid cancer, and the CTGF protein might serve as a valuable target for early diagnosis and treatment of thyroid cancer in clinic.

Adult ; Female ; Granuloma, Plasma Cell ; pathology ; Humans ; Maxillary Sinus ; pathology ; Paranasal Sinus Diseases ; pathology

Objective To find out common allergens in Rizhao by investigating the allergens in patients with allergic rhinitis.Method The allergens in 686 patients with allergic rhinitis in Rizhao were detected by skin prick test.Results 509 of 686(74.20%)cases presented positive reaction,in which,the positive rate was 70.99%in inhalation group and 30.61%in food group,the most common inhalation allergen was pteronyssinus,then was dermatophagoides farinae,cockroaches;The most common food allergen was the jellyfish,then was peaches,peanuts.Conclusion The inhaled allergens were the main risk factors for allergic rhinitis,in which,mites was the most common allergens.

Rare sugars were defined as monosaccharides and their derivatives that rarely exist in nature. They played an important role in food, health, medicine and etc A strategy for bioproduction of rare sugars, namely Izumoring, was described. By the Izumoring method, all monosaccharides and polyols could be linked, using enzymatic reaction with D-tagatose 3-epimerase, aldose isomerases and polyol dehydrogenases. Izumoring for hexoses, pentoses and tetroses were designed respectively. According to this strategy, the bioproduction routes of various rare sugars, using microbial and enzymatic reactions, could be obtained. In addition, the future research tendency of biotransformation of rare sugars was put forward.

An extracellar fibrinolytic strain was isolated from fermented shrimp paste. In addition to general physiological and biochemical properties, the strain was identified by 16S rDNA sequence and systematic analysis. The results showed that 16S rDNA sequence of the strain had high similarity with AY601723 and AB195282, suggesting that the strain is a subspecies of Bacillus sp. It was named as Bacillus sp. nov. SK006 by CCTCC. The medium composition and fermentation conditions for fibrinolytic enzyme production were also optimized in the research.