Vascular endothelial growth factor can induce angiogenesis in vivo.Phosphoinositide 3-kinase signaling pathway widespreads in cells,which plays important roles in cell growth,proliferation,differentiation,and angiogenesis.The phosphoinositide 3-kinase signaling pathway can activate vascular endothelial growth factor,such as hypoxia-inducible factor-1,insulin-like growth factor-Ⅰ,nitric oxide synthaseand cyclooxygenase-2.The present studies have shown that the vascular endothelial growth factor and phosphoinositide 3-kinase signaling pathway play an important role in the retinopathy of prematurity.

0.05). But the Wuling Sang could obviously decrease serum TG content than Simvastatin(P0.05). The adverse drug reactions were stomach discomfort(4 patiens in SWS) group, 5.71%), abdominal discomfort(2 patiens in Simvastatin group, 4.55% ) and sleeplessness(5 patiens in Simvastatin group, 11.4%) . CONCLUSION: The results show the TCM drug SWS is effective and softy on treating the patients with primary hyperlipemia.

Cardiopulmonary bypass(CPB) can induce systemic inflammatory response syndrome(SIRS).This review elaborated the influences of SIRS in acute lung injury after CPB.

In 54 cases of pulmonary hypertension, the PaCO2 was markedly lowered, PaO2 and SaO2 elevated, HR, CO and mPAP, PVR all lowered in the treatment group (P0. 05), but SBP was significantly different (P

Beta blocker can be categorized by non-selective agents,selective agents and agents with vasodilatory effect.Beta blocker therapy represents a major advance in the treatment of heart failure patients.The mechanisms include up-regulation of beta receptor,reversing remodeling,improving contractile and diastolic function,antiarrhythmia and anti-ischemia.Evidences from randomized controlled clinical trials have supported its use in the treatment of patients with heart failure to decrease mortality and improve life quality.Guidelines with various versions recommend that ?-blockers are indicated for patients with symptomatic or asymptomatic heart failure and a depressed ejection fraction of lower than 40%.There is something to be noticed for rational use of ?-blockers such as timing,dosage,duration and contraindications.

Cardiopulmonary bypass(CPB) is often followed by pulmonary dysfunction,and is also regarded as a high risk factor for development of acute respiratory distress syndrome(ARDS).This article reviewed the recent researches of the mechanisms of lung injury induced by CPB.

The catabolic response to severe injury , burn, inflammatory ,acute pancreatitis and operation is characterized by whole-body protein loss, mainly reflecting increased breakdown of muscle proteins. Glucocorticoids and various proinflammatory cytokines are important regulators of muscle proteolysis in stressed patients. In recent years, three types of treatments have been used to reduce or prevent the catabolic response to injury and sepsis: ①nutritional, ②hormonal, and ③pharmacologic. This article review the catabolic response and the corresponding interruption under the stress conditions.

OBJECTIVE To investigate the advantages of nicardipine induced hypotension in endoscopic sinus surgery.METHODS Eighty patients underwent endoscopic sinus surgery under general anesthesia were randomly assigned into two groups(n=40 each):Group A(Enflurane Group), Group B (Nicardipine Group).The effect of controlled hypotension was compared between the two groups.The changes of MAP, HR were recorded during induced hypotension, the time of induction, maintenance and recovery in induced hypotension were recorded.RESULTS 1.The induced hypotension induction time in group A was significant shorter than that in group B, BP recovery time in group A was obviously longer than that in group B (P

Nosocomial infection is a serious problem in the diagnosis, treatment and management of neonatal disease. Neonatal intensive care unit (NICU) is high risk place for nosocomial infections whose clinical features vary with age, nation and region. The improvemnts in hand hygiene measures and antibiotic stewardship and control of the risk are recommended to effectively prevent nosocomial infections in NICU and to improve the healthcare service in neonates.