0.05). But the Wuling Sang could obviously decrease serum TG content than Simvastatin(P0.05). The adverse drug reactions were stomach discomfort(4 patiens in SWS) group, 5.71%), abdominal discomfort(2 patiens in Simvastatin group, 4.55% ) and sleeplessness(5 patiens in Simvastatin group, 11.4%) . CONCLUSION: The results show the TCM drug SWS is effective and softy on treating the patients with primary hyperlipemia.

Cardiac Resynchronization Therapy ; China ; Chronic Disease ; Heart Failure ; therapy ; Humans ; Practice Guidelines as Topic

Carried on the exploration testing of flow rate of infusion device about industry standard YY 0451-2010. Engaged in flow rate experiments adopting different method that are provided by new and old industry standard for samples of the same type. Compared with the result of the dangerous coefficient by calculating the test data, the old standard can be more sensitive to reflect the situation of product flow rate, so it can be applied to conventional control of the products. The method which provided by the new industry standard is suitable for evaluating periodicity the level of product contaminated.
Flowmeters ; Infusion Pumps

Neutrophil genatinase-association lipocalin(NGAL)is a kind of lipocalin of binding proteins that seems to be a popular topic studied much recently,which at first was considered as endogenous bacteriostatic agent.It is bound up with the occurrence,development and prognosis of many kidney diseases.Therefore,it can provide new idea and method on clinical diagnosis and treatment by further study on expression and significance of NGAL in kidney diseases.

The antihypertensive treatment protocols of 4102 patients from the database of Changbai Community Health Service Center of Shanghai Yangpu District were analyzed.Patients with irregular drug treatment were excluded in the study.In 4102 hypertensive patients,45.6% took calcium channel blockers (CCB),16.0% took angiotensin converting enzyme inhibitors ( ACEI),3.6% took AT1-receptor blocker (ARB),9.0% took β-adrenergic receptor blockers,4.7% took diuretics and 21.1% took compound preparation.68% patients were in single-drug protocol,29.3% in two-drug,2.6% in three-drug and 0.1% in four-drug.In patients with two-drug protocol,75.8% was based on CCB; three-drug or four-drug protocols were also based on the combination of CCB.The results indicate that the treatment protocol for hypertensive patients in our community health service center basically meets the requirements of International Society of Hypertension Treatment Guidelines,but the proportion of the single drug use seems to be high,more combination of antihypertensive drug use should by proposed.

Neonatal jaundice is one of the common diseases in preterm neonates. But there are still some problems to be determined,for example,the clinical diagnosis criteria for neonatal jaundice,the prediction,diagnosis and therapies for hyperbilirubinemia,and diagnosis for bilirubin encephalopathy in early-stage and prevention from bilirubin encephalopathy sequelae.

Insulin is one of the most important hormonal regulators of metabolism. Since the diabetes patients increase dramatically, the chemical properties, biological and physiological effects of insulin had been extensively studied. In last decade the development of NMR technique allowed us to determine the solution structures of insulin and its variety mutants in various conditions, so that the knowledge of folding, binding and stability of insulin in solution have been largely increased. The solution structure of insulin monomers is essentially identical to those of insulin monomers within the dimer and hexamer as determined by X-ray diffraction. The studies of insulin mutants at the putative residues for receptor binding explored the possible conformational change and fitting between insulin and its receptor. The systematical studies of disulfide paring coupled insulin folding intermediates revealed that in spite of the conformational variety of the intermediates, one structural feature is always remained: a "native-like B chain super-secondary structure", which consists of B9-B19 helix with adjoining B23-B26 segment folded back against the central segment of B chain, an internal cystine A20-B19 disulfide bridge and a short α-helix at C-terminal of A chain linked. The "super-secondary structure" might be the "folding nucleus" in insulin folding mechanism. Cystine A20-B19 is the most important one among three disulfides to stabilize the nascent polypeptide in early stage of the folding. The NMR structure of C.elegans insulin-like peptide resembles that of human insulin and the peptide interacts with human insulin receptor. Other members of insulin super-family adopt the "insulin fold" mostly. The structural study of insulin-insulin receptor complex, that of C.elegans and other invertebrate insulin-like peptide, insulin fibril study and protein disulfide isomerase (PDI) assistant proinsulin folding study will be new topics in future to get insight into folding, binding, stability, evolution and fibrillation of insulin in detail.

To investigate the cause,pathogenesis,monifestation and treatment of osteoporosis and bonic arthritis.Bonic arthristis was not the osteoposis.Osteoporosis and bonic arthristis may occured simultaneously.In order to treat the conditions correctly,differentiated diagrosis should be noticed clinically.

[Objective] To explore the levels of folic acid(FA), vitamin(Vit) Bl2 and homocysteine(Hcy) of gestational diabetes mel itus(GDM) patients and the relation among them. [Method] Select 40 GDM cases from our hospital diagnosed with oral glucose tolerance test(0GTT) and 40 healthy pregnant women in the same period, take circulation enzymic method to test Hcy concentration, and take chemiluminescence to measure FA and VitBl2. [Result] GDM patients’Hcy level is in negative relation with VitBl2 and FA levels. Comparing GDM patients’serum Hcy,VitBl2 and FA with normal pregnant group,Hcy level is raised much(P<0.01), FA and VitBl2 are reduced markedly(P<0.01). In later period of GDM pregnancy, they have high Hcy, lack of FA and Vit-Bl2; the pregnancy hypertension shal strengthen the intake of VitBl2 and FA, as wel as have periodical supervision, to reduce Hcy level and decrease the side effects on fetus and injury to pregnant women’s great vessels and micro-vessels.

Objective To identify the researchers' productivity,the citation states and the grant patterns of the Chinese Journal of Hepatobiliary Surgery through citation analysis.Methods Articles published in the Chinese Journal of Hepatobiliary Surgery between 2009 to 2012 were collected from the Chinese Science Citation Database.These articles were analyzed with statistics and bibliometrics.The indicators included cooperation degree,core authors,distribution of grant,authors' origin and citation states.Results Of the 1321 papers which were published by the journal during the study period,505 papers were cited 923 times.Of the 1111 first authors,957 (86.14％) published one paper only.There were 154 core authors (13.86％ of first authors),and they published 364 papers (27.55％).There were 14 high-productivity institutes,which published 299 papers (22.63％).According to the geographical distribution,Beijing ranked first with 190 (14.38％) papers.The second was Shanghai with 156 (11.81％),the third was Jiangshu province with 134 (10.14％),the fourth was Zhejiang province with 132 (9.99％),and the fifth was Guangdong province with 101 (7.65 ％) papers.1262 papers were completed by collaborate teams of more than one author.The cooperative rate was 95.53％ and the cooperative degree was 4.67.361 papers were funded by 553 supporting foundations.Conclusions The authors of the Chinese Journal of Hepatobiliary Surgery were geographically widely distributed.Some were core authors with high-productivity.They were highly cited and with good cooperation degree.Beijing,Shanghai,Jiangshu,Zhejiang and Guangdong provinces play important roles in research on hepatobiliary surgery.