0.05). But the Wuling Sang could obviously decrease serum TG content than Simvastatin(P0.05). The adverse drug reactions were stomach discomfort(4 patiens in SWS) group, 5.71%), abdominal discomfort(2 patiens in Simvastatin group, 4.55% ) and sleeplessness(5 patiens in Simvastatin group, 11.4%) . CONCLUSION: The results show the TCM drug SWS is effective and softy on treating the patients with primary hyperlipemia.

Objective To explore the effect of health education with integrated traditional Chinese and western medicine on patients with cardio-cerebrovascular disease, in order to reach the aim of preven-tion and treatment of cardio-cerebrovascular disease, promotion of early rehabilitation and maintenance of health in them. Methods 80 cases of patients with cardio-cerebrovascular disease were randomized into the control group and the intervention group with 40 cases in each group, Both groups received routine treatment, the intervention group received health education based upon routine treatment. Questionnaires were formulated to investigate change of bad habit and primary disease,return visit and incidence of compli-cation one year after intervention, X2 test was adopted. Results The change rate of bad habit was higher, the change rate of primary disease,rate of return visit and incidence rate of complication were lower in the intervention group compared with those in the control group. Conclusions Health education with inte-grated traditional Chinese and western medicine for patients with cardio-cerebrovascular disease can in-crease their cognition of self- care,life quality and health level which is worthy of wide application in clinic and community.

Gastroenterology ; Humans

Neutrophil genatinase-association lipocalin(NGAL)is a kind of lipocalin of binding proteins that seems to be a popular topic studied much recently,which at first was considered as endogenous bacteriostatic agent.It is bound up with the occurrence,development and prognosis of many kidney diseases.Therefore,it can provide new idea and method on clinical diagnosis and treatment by further study on expression and significance of NGAL in kidney diseases.

Objective To analyze clinical characteristics, hospital treatment, complications and mortality differences of the patients with acute myocardial infarction (AMI) by conventional treatment. Methods Retrospective analysis of 426 cases of AMI patients, aged 20-103 years [mean age(67. 82 ±0. 56) years] ,male 261 cases,female 165 cases, the general condition of patients were recorded, history features, diagnosis, treatment, complications and prognosis. Comparison of elderly(≥70 years) and non-elderly(＜70 years) ,male and female patients with clinical features, treatment, complications and mortality differences. Results Compared with the non-elderly patients with AMI,elderly patients had significantly lower smoking history(P＜0.05) ,female ratio,history of old myocardial infarction rate, cardiac function≥Killip Ⅲ level was significantly higher(all P＜0.05). During hospitalization in patients of different ages diuretics,β blockers, digitalis, clopidogrel and other drugs, application of a significant difference (all P＜0.05). Elderly AMI patients with complete left bundle branch block,atrioventricular block,atrial fibrillation,the incidence was higher than non-elderly patients (all P＜0.05) ,but no difference in mortality between the two groups (P＞0.05). Female patients than male patients with age of onset was significantly (P＜0.05) , and the smoking rate is low,but clearly the high rate of angina died(P＜0.05) ,sub-poor cardiac function after myocardial infarction(P＜0.05). Application of cardiac drugs in addition to nutrition than men,female patients, the rate of other conventional therapy,no difference in both complications and prognosis(all P＞0.05). Conclusion AMI was the major diseases threatening human life,different age had its own clinical characteristics of patients,and it could not be impacted by gender.

Objective To investigate the expression and distribution of cellular FLICE( Fas-assoelated death domain-like interleukin-I β-converting enzyme-like)-inhibitory protein (c-FLIP) in peripheral blood and lesions of lichen planus patients. Methods Peripheral blood and skin samples were obtained from 30 patients with lichen planns and 20 normal controls. Flow cytometry was used to detect intracellular c-Fl,lP in peripheral T and B lymphocytes, and immunohistochemistry was used to examine the expression of c-FLIP in lesionai tissue. Results Based on the pesitivity rate of c-FLIP, there was a significant increase in T iymphocytes in lichen planus compared with normal controls(6.32%±1. 17% vs 2.28%±0.54%, P < 0.05 ), while no significant difference was found in B lymphocytes between two groups (0.78% ±0. 16% vs 0.69% ± 0. 18%, P >0. 05 ). The expression intensity of c-FLIP in keratinocytes was also higher in lichen planusthanthatinnormalcontrols ( 89.73%± 5.24% vs 121.58% ±7.93% ,P < 0. 01 ). Conclusion c-FLIP is highly expressed in lesions and peripheral T lymphocytes of patients with lichen planus, which suggests the possible involvement of c-FLIP in the proliferation of T lymphocytes in lichen planns.

Objective To investigate the clinical effect of treating avascular necrosis of femoral head with comprehensive therapy dominated by medical ozone. Methods Joint cavity of femoral articulation was performed blockage and injected with fluids for eliminating inflammation and reliving pain. After 5 to 10 minutes interval, if the patients did not show any abnormal reaction, medical Ozone with the concentration of 30%, 8 to 10ml, was injected to the joint cavity. Meanwhile, needle-knife therapy was used to reduce pressure inside the cavity. Traditional Chinese medicine was also used for the treatment. Results of all 183 femoral articulations of 135 cases, the therapeutic result of 38 articulations perfect, occupying 20.8% (38/183), 88 were good, occupying 48.1% (88/183), 31 were normal, occupying 16.9% (31/183) and 26 were bad, occupying 14.2% (26/183).The total effective rate was 85.8% (157/183). Conclusion The treatment of avascular necrosis of femoral head with comprehensive therapy dominated by medical ozone had outstanding therapeutic effects.

9-Nitrocamptothcin(9-NC)is an orally available new type camptothecinanalog with antineoplastic activity that results from inhibition of DNA topoisomerase Ⅰ.In the study we reviewed the feature of the drug,mechanism of action,update studies of preclinical and pancreas cancer clinical trial.

Toxicity has impeded the advance of chemoradiotherapy for head and neck cancer, while targeted therapy has demonstrated some advantage. Over the past decade, targeted therapy is becoming the important section in multimodal approaches for head and neck cancer. Targeted drugs include monoclonal antibodies, small molecular chemicals and antisense oligodeoxynucleotide, etc. Cetuximab is the only targeted agent approved for this malignancy, and other targeted drugs, such as gefitinib and lapatinib, have demonstrated encouraging outcome in phase Ⅰ -Ⅲ clinical trials for head and neck cancer.

Objective To explore clinical significance of controlled mechanical ventilation under general anesthesia with blood gas analysis. Methods 90 adult patients who received operation under general anesthesia were ysis was made 30 min after anesthesia and per hour thereafter. The patients whose first arterial blood gas values were abnormal were made another blood gas analysis 25 min after adjusting their respiratory parameters. Results The fist blood gas analysis values of the patients showed that the average PaCO2 value was ( 33.6 ± 12.9 ) mm Hg, only 40. 0% were normal;The average pH value was(7.40 ±0.05) ,66.7% were normal. Ventilation parameters of 36 cases whose first PaCO2 were abnormal were adjusted according to their first PaCO2. The average PaCO2 value of the second blood gas analysis was ( 37. 1 ± 4.6) mm Hg,90. 0% were normal and higher than the first ( P < 0. 05 ). The average pH value was (7.38 ± 0. 02 ),91.1% were normal and it was higher than the first( P < 0. 05). Conclusion It was important for arterial blood gas analysis to direct controlled respiration under general anesthesia.