Objective To compare the clinical effect of hypertensive intracerebral hemorrhage treated by small bone window craniotomy or craniotomy.Methods 192 cases of patients with hypertensive cerebral hemorrhage treated were selected and divided into minimally invasive group and flap group randomly.Small bone window craniotomy was used in minimally invasive group,while large trauma craniotomy was used in flap group.Complications,rebleeding and short and long term efficacy were recorded and compared.Results 6 cases(6.3％) of.incidence of complications in minimally invasive group,while 14 cases(14.56％) in flap group,the rate in the former group was lower than that in the latter group (x2 =51.308,P ＜ 0.05).There was no significant difference of rebleeding between the two groups (P ＞ 0.05).3 weeks later,GCS score was (10.9 ± 1.8),GOS score (3.3 ± 0.6),BI index (47.8 ±11.5) and 64 cases' nerve function improved (66.7 ％) in minimally invasive group,while GCS score (10.1 ± 2.5),GOS score(2.7 ±0.8),BI index (33.5 ± 15.4) and 31 cases' nerve function improved(32.3％) in flap group.The GOS score,BI index and the situation of nerve function improvement were better in minimally invasive group than that in flap group(t =15.758,56.529,x2 =72.149,P ＜0.05).None of the patients were dead,and there were no significant differences of GCS score between the two groups(P ＞0.05).6 months later,no significant difference of GCS score and mortality were found between the two groups (P ＞ 0.05).but the mean score of GOS and BI index were higher than those in flap group (t =11.647,32.990,P ＜ 0.05).Conclusions Both large trauma craniotomy and small bone window craniotomy could reach therapeutic purposes.However,intraoperative and postoperative complications could be deceased by small bone window craniotomy,and short and long term GOS score and BI are higher,the short term nerve function improvement is better.

Colon carcinoma is one of the most common malignant neoplasms.The incidence of this disease has been increasing significantly in recent years in China.Ahhough diagnostic and therapeutic methods have been im proved greatly.carcinoma invasion and metastasis are considered to be the main causes of poor prognosis and death. Tumor metastasis is a complicated process with multiple steps and factors.Cell adhesion molecule(CAM)play a very impntant role in this process while it expresses exceptionally or loses its function.CAM is a kind of glycopro tein molecule by the cell synthesis which mediates the intereontact and intercombination between cell and cell or be tween cell and matrix.It takes part in a series of important physiologic and pathologic processes,such as cell signal conduction and activation,cell extension and migration,tumor metastasis and wound healing,and so on.

Objective To analyze the relationship between preoperative biochemical indexes and effect ofpostoperative first 131I internal irradiation for differentiated thyroid carcinoma. Methods One hundred and eighty patients of thyroid carcinoma within the first 131I internal irradiation postoperative. According to curative effect were divided into effective group (96 cases) and invalid group (84 cases) and their clinical data were retrospectively analyzed. Results The preoperative serum alkaline phosphatase (AKP) and thyroid-stimulating hormone (TSH) in effective group and invalid group were respectively (74.83 ± 19.77),(65.50 ± 11.84) U/L and (3.12 ±0.59), (2.57 ±0.56) mU/L. There were significant difference (t =3.77,6.39, P < 0.01) between two groups. Conclusion The levels of preoperative serum A KP and TSH are important factors to influence the effect of postoperative first 131I internal irradiation for differentiated thyroid carcinoma.

Early detection of HCC is critical for a good prognosis. Therefore, the development of tumor markers that can detect HCC at even earlier stages is urgent. Recent researches show that the human cervical cancer oncogene, gamma-glutamyl transferase mRNA, human telomerase reverse transcriptase mRNA, the proteins such as glypican-3, golgi protein 73, vascular endothelial growth factor and transforming growth factor-β1 could serve as markers for early detection of HCC.

ObjectiveTo explore the efficacy of large trauma craniotomy with bilateral frontal coronal incision in treating contusion and laceration of bilateral frontal lobes.MethodsThe clinical data of 68 patients with contusion and laceration of bilateral frontal lobes who were treated with bilateral decompressive craniectomy were analyzed retrospectively.There were 36 cases(observation group) treated with large trauma craniotomy with bilateral frontal coronal incision and 32 cases (control group) given bilateral decompressive craniectomy by stages.The prognosis of two groups were observed and compared.The prognosis was evaluated at 6 months after surgery by Glasgow outcome scale (GOS) score.ResultsThere were 23 cases (63.89％,23/36) who got good recovery,8 cases(22.22％,8/36) with poor prognosis and 5 dead cases (13.89％,5/36) in observation group.There were 11 cases (34.38％,11/32) who got good recovery,9 cases (28.12％,9/32) with poor prognosis and 12 dead cases (37.50％,12/32) in control group.The rate of good recovery and mortality between two groups had significant differences (P ＜ 0.05).ConclusionsThe large trauma craniotomy with bilateral frontal coronal incision can significantly relieve or ease intracranial hypertension of patients with contusion and laceration of bilateral frontal lobes.And it can improve the prognosis and decrease the mortality.

Epstein-Barr virus infects widely, and has a powerful ability to transfrom into a number of malignant diseases. The infection is mostly latent, without any obvious clinical symptoms. At present, more and more researches have found that cell-mediated immunity,especially T lymphocyte response plays an important role in the control of Epstein-Barr virus infection.

Objective To study the significance and function of the comprehensive weight in multiple linear regression analysis of complex random sampled data .Methods Based on the concept of Monte Carlo random simulation , two different multiple linear regression analysis procedures in SAS-REG and SURVEYREG were used to perform regression modeling for the same batch of complex random sampled data ( n=6756 ) at different random sampling proportions .The results were compared.Results In the results of the fitting multiple linear regression model when observation weight and sampling weight were considered or not , it was found that the size of the partial regression coefficient , standard error and P value of independent variables varied .Conclusion In complex random sampled data based on different proportions ,especially in regression modeling of stratified random sampling survey information , the multiple linear regression model makes it possible to more accurately and sensitively perform parameter estimates of regression coefficients and statistical prediction of outcome variables if the comprehensive weight of the survey data is incorporated into the statistical analysis .

OBJECTIVE:To study the professional risks of Chinese clinical pharmacists.METHODS:The source and avoidance of professional risks for clinical pharmacists were analyzed on the basis of current practice and literatures.RESULTS:Lack of clarity in duties and rights of clinical pharmacists,undefined criteria for evaluation of their works were among the main causes of their professional risks.CONCLUSION:It is essential to renew and implement the related regulations and guidelines on clinical pharmaceutical practice to minimize the professional risks,which should be responded both by the authority and professionals.

Objective:To investigate the effect and safety of sufentanil combined with propofol for intravenous anesthesia in chil-dren undergone painless gastroscopy. Methods:Totally 120 cases of children undergone painless gastroscopy were divided into the ob-servation group (60 cases) and the control group (60 cases) according to the random number method. The observation group was given sufentanil combined with propofol for anesthesia, and the control group was given fentanyl and propofol for anesthesia. The hemodynam-ic indices at the period of T0 (before the anesthesia), T1 (1 min after the anesthesia induction), T2 (checking), T3 (2min after the checking) and T4 ( at the end of testing) were compared between the groups, and the anesthesia situation, hospitalization time, dosage of propofol, fine/excellent rate of anesthesia and adverse reactions were also observed. Results:In T1, T2 and T3, the MAP ( mean arterial pressure) , HR ( heart rate) and RR ( respiratory rate) were declined in the two groups when compared with those in T0 ( P<0. 05), and those in the observation group were higher than those in the control group (P<0. 05). The time of consciousness disap-pearance, eyes open, orientation force recovery and hospitalization in the observation group was shorter than that in the control group, and the propofol dosage in the observation group was lower than that in the control group(P<0. 05) . The excellent number and rate of the observation group were better than those of the control group (P<0. 05), and the incidence of apnea of the observation group was lower than that of the control group (P<0. 05). Conclusion: Sufentanil combined with propofol for anesthesia in children undergone painless gastroscopy has the properties of fast onset and recovery, stable hemodynamic indices during the operation and high safety, which is worthy of promoted application.

Objective To investigate the relevance between relapse and course of treatment in genotype 1 chronic hepatitis C (CHC)pa-tients with slow virologic response.Methods Totally 157 genotype 1 CHC inpatients or outpatients were selected from the Third People′s Hospital of Jiaozuo and the People′s Hospital of Jiaozuo from April 2010 to March 2013.The patients were treated with interferon α-1b in conjunction with ribavirin.At 6 months of the initial treatment,5 1 patients with slow virologic response were randomly divided into groups A (24 cases)and B (27 cases),which received continued treatment for another 6 and 12 months,respectively.A 1 -year follow-up of pa-tients was performed after withdrawal of treatment.Adverse reactions in patients receiving the antiviral therapy were assessed.Furthermore, group comparisons were performed on the clearance rate of hepatitis C virus (HCV)RNA and normalization rate of alanine aminotransferase (ALT)at withdrawal of treatment,as well as the CHC relapse rate and ALT normalization rate at 6 months and 1 year after withdrawal of treatment.Continuous data were compared using t test,and categorical data were compared usingχ2 test.Results The rate of adverse reac-tions in patients receiving antiviral therapy had no significant difference between groups A and B (P>0.05 ).At withdrawal of treatment, there were no significant differences between groups in terms of HCV RNA clearance rate (95.65%vs 92.59%)and ALT normalization rate (95.65% vs 88.89%)(χ2 =0.02 and 0.13,respectively,both P>0.05).At 6 months and 1 year after withdrawal of treatment,the CHC relapse rate in group B was significantly lower than that in group A (20.00% vs 50.00%,χ2 =4.69,P <0.05;36.00% vs 68.18%,χ2 =4.85,P<0.05);the ALT normalization rate in group B was nonsignificantly higher than that in group A (84.00% vs 59.09%,χ2 =3.63,P>0.05;72.00% vs 50.00%,χ2 =2.40,P>0.05).Conclusion To extend the 6 -month course of treatment can significantly reduce the relapse following slow virologic response in patients with genotype 1 CHC.