Cardiovascular disease(CVD) is a common fingding in paitients with chronic renal failure(CRF),its pathogenesis is not clear.In the past decade,the relation reduce of EPO,malnutrition and inflammation,endothelial dysfunctin and angiodysplasia with pathogenesis of CVD had been investigated,These risk factors inducing CVD were reviewed.

The role of the microvascular disease in progressive renal disease is not well understood .This review presents evidence that progressive renal disease is characterized by a progressive lose of the microvasulature. And presents the factors that induce the lose of the microvasculature. Try to find out (agents) which may represent a novel therpeatic approach for slowing the renal disease.

Objective To explore the effect of c-Jun NH2-terminal kinase(JNK)signal transduction pathway on hyperoxia-induced lung injury in rats.Methods Twenty-four Wistar rats aged 3 weeks were randomly divided into 3 groups(n=8):room-air control group,7 d hyperoxia exposure group,and 7 d hyperoxia exposure with inhibitor of JNK intervention group.The rats in hyperoxia exposure group were exposed to high concentration of oxygen [fractional concentration of inspired oxygen(FiO2)≥950 mL?L-1] at normal pressure.The rats in room-air control group were placed in room air(FiO2=210 mL?L-1)at normal pressure.The rats in JNK inhibitor intervention group were intraperitoneally injected 30 mg?kg-1 SP600125 and exposed to hyperoxia 2 h later.The histopathological changes of lung tissues were observed by means of light microscope,therefore the changes of lung W/D weight ratio,total protein in bronchoalveolar lavage fluid(BALF)and lung permeation index were detected.The extent of lung cells apoptosis was analyzed by terminal deoxynucleotidyltrans-ferase-mediated dUTP nick end labeling assay.The protein level of p-JNK was measured by Western blotting analysis.Results Compared with room-air control group,conspicuous hyperaemia,edema,hemorrhage and extensive inflammation cells infiltration in the lung tissues were significantly observed in 7 d hyperoxia exposure group.The lung W/D weight ratio,total protein in BALF,lung permeation index,cell apoptotic index and the p-JNK protein levels of lung tissues all significantly increased in 7 d hyperoxia exposure group compared with those in room-air control group(Pa

As the subject of educational scientific research work,teachers are the first driving force of curriculum reform and specialty building in school.The deployment and quality of teachers are closely related to scientific research achievement.In order to ascertain their relationship the situation of articles published papers and scientific projects have been analysed combined with the age professional titles and educational background of teachers in our college,which may provide preferences for the sustainable development of the school.

Objective To analyze and discuss the clinical effect of montelukast in the treatment of children with mycoplasma pneumoniae infection.Methods 21 7 children with mycoplasma pneumoniae infection were collect-ed,98 cases of airway height response after infection were selected as the research subjects in this observation,who were randomly divided into control group and observation group,among them 49 patients in the control group received conventional treatment,while 49 cases in the observation group added montelukast treatment based on the control group.The clinical effect and the occurrence of adverse reaction after 1 week of treatment were compared,at the same time,compared and discussed irritating cough onset,continue time,decrease time of cough and treatment time in the two groups.Results There were no adverse reactions in the two groups of children after treatment,98 cases were all cured,which suggested that the test was a complete success.The clinical efficacy of the control group after 1 week was 71 .43%,which was 97.96% in the observation group;In the control group,the duration of the stimulus onset,dura-tion,duration of treatment,treatment time and time of treatment were (5.20 ±2.64)d,(1 2.50 ±3.82)d,(1 3.1 0 ± 4.1 5)d,(20.80 ±1 0.65)d,which of the observation group were (4.1 0 ±0.27)d,(7.40 ±2.43)d,(8.90 ± 0.36)d,(1 6.40 ±8.32)d,the differences were statistically significant (t =2.901 ,7.885,7.057,2.279,all P <0.05).Conclusion Montelukast can promote and consolidate the curative effect in the treatment of airway hyper responsiveness in children with mycoplasma pneumoniae infection,it is recommended to promote in clinical because it has no serious side effects.

Objective To evaluate the curative effect of dydrogesterone and luteosterone in the treatment of threatened abortion.Methods PubMed,Chinese CNKI,Wanfang database were searched by computer.The randomized controlled trials (RCT) of dydrogesterone and luteosterone in the treatment of threatened abortion(RCT) were collected.Retrieval time was January 2011-March 2016.According to the inclusion and exclusion criteria,the two reviewers independently screened the literature,extracted data and evaluated the quality of themethod,the Rev Man 5.3 software was used for Meta analysis.Results In the final 8 RCT,a total of 1 438 patients were selected.Meta analysis showed:676 cases of 719 patients had clinically effective in the dydrogesterone group,and 605 cases of 719 patients had clinically effective in the luteosterone group(OR =2.94,95％ CI =2.04 ～ 4.24).The clinical effect of the dydrogesterone group was significantly higher than that of the luteosterone group(P ＜ 0.01).The funnel plot was basically symmetrical,and the publication bias was small.The occurrence incidence rate of adverse reactions of the dydrogesterone group was lower than that of the luteosterone group (OR =0.57,95％ CI =0.36 ～ 0.89,P =0.01).The backache relief time of the dydrogesterone group was significantly lower than that of the luteosterone group(MD =-4.96,95％CI =-5.18 ～-4.73,P ＜ 0.01).The relief time of abdominal pain of the dydrogesterone group was significantly lower than that of the luteosterone group (M D =-0.85,95 ％ CI =-1.23 ～-0.46,P ＜ 0.01).The hemostasis time of the dydrogesterone group was significantly lower than that of the luteosterone group (MD =-2.87,95％ CI =-3.52 ～-2.22,P ＜ 0.01).Conclusion Compared with the oral luteosterone,dydrogesterone in the treatment of threatened abortion has higher effective rate,less adverse reactions,and the relief time of backache and abdominal pain,hemostasis time is shorter,so dydrogesterone for threatened abortion is obviously better than luteosterone capsules,and it is worthy of clinical reference.

Aptamers are short nucleic acids or peptides that strongly bind to a protein of interest and functionally inhibit a given target protein at the intracellular level. Besides high affinity and specificity, aptamers have several advantages over traditional antibodies. Hence, they have been broadly selected to develop antiviral agents for therapeutic applications against hepatitis B and C viruses (HBV, HCV). This review provides a summary of in vitro selection and characterization of aptamers against viral hepatitis, which is of practical significance in drug discovery.

Objective To investigate recurrence of colorectal adenoma (CRA)after polypectomies and colonoscopic surveillance,and to explore risk factors related to CRA recurrence.MethodsFrom June 2005 to December 2009,in the Fist Affiliated Hospital of Anhui Medical University,the clinical data of 283 hospitalized patients who underwent CRA polypectomy and met the study criteria were collected and followed up.The recurrence rate of CRA after polypectomies,the relationship between colonoscopic surveillance interval and CRA recurrence and risk factors related to recurrence were analyzed.The colonoscopic surveillance interval,frequency and the reason for no colonoscopic surveillance were also analyzed.ResultsA total of 235 post-polypectomies CRA patients were successfully followed up,the follow-up rate was 83.0％ (235/283).The shortest follow-up period was 12 months and the longest was 66 months,the median follow-up time was (35.1 ± 14.2)months.A total of 115 patients were underwent colonoscopic surveillances,the surveillance rate was 49.4％ (115/233).The recurrence rate was 45.0％ (50/111) in colonoscopic surveillance group.A total of 118 patients were without colonoscopic surveillances.Age over 60 years,body mass index over 25 kg/m2 and multiple adenomas (≥ 2) were significantly related with CRA recurrence,and the difference was statistical significant (P＜ 0.05).The rate of awareness that CRA needed regular surveillance group without surveillonce was significantly lower than that of group with surveillance.(P＜0.01).ConclusionThe recurrence rate of CRA after polypectomies is high.Age,high body mass index and multiple adenomas are predicted independent risk factors for CRA recurrence.Lacking awareness of the importance of regular surveillances after polypectomies is the main reason for low colonoscopic surveillance rate after polypectomies in our hospital.

BACKGROUND:The essence of cell differentiation is a selectively intra-cellular gene expression,which results in specific proteinic synthesis and causes changes in biochemistry,structure and function.Thus,original proteomics and a single protein analysis can not meet the requirement in study.Proteomics technology provides a powerful tool due to the large scale,systemical study of protein transformation and interaction,which can be used for exploring molecular mechanism of bone mesenchymal stem cells(BMSCs)during directional differentiation.OBJECTIVE:To introduce proteomics,to summarize the research of proteomics in directional differentiation of BMSCs,and to forecast the development of proteomics research methods.METHODS:To search articles highly related with BMSCs,cell differentiation,and proteomics published on CNKI (www.cnki.net/index.htm),Sciencedirect(http://www.Sciencedirect.com),I.S.I(http://www.isiwebofknowledge.com)were searched,and the key achievements were included in the analysis.RESULTS AND CONCLUSION:A total of 29 documents were reviewed,and the experiences in the application of proteomics technology in the directional differentiation of BMSCs were summarized.With the innovation and development in methodology and technology,proteomics will become a powerful tool for us to study the potential mechanisms of BMSCs directional differentiation.