Objective To investigate the relationship of serum levels of C-reactve protein (CRP) with diabetic cardiomyopathy (DCM). Method Thirty-six patients with DCM were recruited as DCM group and thirty healthy people as the control. Serum levels of CRP in all subjects were determined by immunoturbidimetry. Results Compared with control group, the serum levels of CRP in patients with DCM were singnificantly increased by about 3.7 folds[(6.95?1.37)mg/dL vs.(1.89?0.38) mg/dL, P

0.05),however,a difference was found in peritumoral region between high-grade gliomas[(1.41?0.288)?10(-9)mm2/s] and metastatic lesions[(1.66?0.164)?10(-9)mm2/s](P0.05).Conclusion Peritumoral MD can be used to distinguish high-grade glilmas from metastatic tumors.

Policosanol is a new drug for regulating lipid,which can inhibit cholesterin synthesis and increase blood clearance of low-density lipoprotein(LDL).It has similar effect as statins and its clinical efficiency,safety and tolerance for special people such as the old and those with hepatopath have been confirmed by many clinical studies.Policosanol combined with statins or fibrates is also safe,which can be used as primary prevention for the patients with hypercholesterinemia,high low-density lipoprotein-cholesterolor low high-density lipoprotein-cholesterol and as secondary prevention for the patients who could not tolerate other lipid-regulating drugs.The long-term clinical effect of Policosanol on the risk factors of atherosclerosis need further researches.

Objective To investigate the diagnostic value of the early slope value of enhancement in differentiating benign from malignant musculoskeletal masses.Methods Dynamic contrast-enhanced gradient-recalled acquisition in the steady state imaging(GRASS) was performed to evaluate 36 musculoskeletal masses(18 malignant,18 benign).The difference of the early slope value of enhancement was analysed and compared between benign lesions and malignant ones.Using ROC curve plotting obtained the best decisive threshold.Spearman rank correlation analysis was used to determine the relation between slope and microvessel density of tumor tissues.Results The average early slope value of enhancement was (4.33?2.70)% per second (range 0.97%～10.50% per second)for malignant lesions,and was (1.46?0.97)% per second(range 0.37%～3.86% per second)for benign ones.There was an apparent statistical significance between benign and malignant tumors(?

Objective To study the changes of cytokines in aqueous humor of patients with proliferative diabetic retinopathy (PDR)after intravitreal bevacizumab (IVB) and the correlation of these cytokines.Methods Fifty-six patients(63 eyes) with severe PDR underwent pars piana vitrectomy (PPV) with IVB pretreatment in our hospital from April,2014 to February,2015 were collected.All the patients received IVB therapy from 3 days to 7 days before PPV.Aqueous humor samples were collected at the time of IVB and PPV treatment.The concentrations of vascular endothelial growth factor (VEGF),interleukin-6 (IL-6),interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) were measured by cytoinetric bead array (CBA).The changes of these cyto-kines after IVB were analyzed by using Wilcoxon rank sum test for paired data.The correlation between these cytokines was analyzed by using Spearman rank test.Results From 3 days to 7 days after IVB,the concentration of VEGF in aqueous humor was (6.57 ± 12.29)pg · mL-1,lower than the pre-operation of (278.71 ±340.20)pg · mL-1,the difference was statistically significant (P ＜ 0.05).The concentration of IL-8 was (385.60 ± 1099.47) pg · mL-1,higher than pre-operation of(298.87 ± 1005.79) pg ·mL-1,the difference was statistically significant (P ＜ 0.05).IL-6 and MCP-1 were increased after IVB,but the difference was not statistically significant (all P ＞ 0.05).VEGF,IL-6,IL-8 and MCP-1 had an obviously relationship between each two factors(all P ＜ 0.05).Conclusion Angiogenesis in patients with PDR are regulated by a variety of cytokines,and targeted reduction of VEGF may compensatory increase the concentration of other inflammatory cytokines.

Cardiovascular Diseases ; psychology ; Humans ; Mental Health

Objective To analyze the cause of constipation of elderly patients with thighbone fracture in order to reduce the incidence of constipation.Methods We gave psychological nursing,activity instruction to 42 elderly patients with thighbone fracture and helped them to form a habit to defecate at fixed time.Results Twelve patients defecated one time every one to two days,Ten patients began to defecate on the second day.26 patients defcated at fixed time.Four patients(9.5%)showed constipation and the symptoms alleviated after use of glycerine enema.Conclusions Selective nursing could settle the problem of constipation for elderly patients with thighbone fracture.It could reduce the pain of patients and promote their rehabilitation.

Endothelial dysfunction plays a crucial role in the development of arteriosclerosis (AS). Accumulating evidence suggests that endothelial dysfunction is an initiating event in the etiology of arteriosclerosis. This article reviewed the relationship between endothelial dysfunction and atherosclerosis, and the effects of therapeutic drugs especially statins on endothelial dysfunction.

Objective To discuss the value of laparoscopic total extraperitoneal repair(TEP) for inguinal hernia.MethodsBetween 2005 and 2007,82 consecutive patients with inguinal hernia at 97 sides underwent TEP by laparoscopy in our hospital.Among the cases [76 men and 6 women with a mean age of 52 years(21 to 88)],9 had unilateral direct inguinal hernia,50 showed unilateral indirect inguinal hernia,and 9 suffered from bilateral indirect inguinal hernia,6 cases were found having bilateral indirect inguinal hernia complicated with direct hernia,and 8 were recurrent cases of indirect inguinal hernia.Results In the patients,5 showed massive postoperative abdominal adhesion;one of them was converted to open surgery because of severe injury to the peritoneum,the other 4 were treated by continuous suture using 5-0 absorbable thread.The operation time for laparoscopic surgery ranged from 30 to 180 minutes(58 minutes for unilateral operation,and 97 minutes for bilateral operation on average).No patient needed analgesics after the procedure.The mean hospital stay for this series was 7 days(range: 4 to 12).Nine patients developed seromas of the scrotum,and was then cured by local drainage and physical therapy.The 82 patients were followed up for 13 to 38 months with a mean of 26 months,during which no one had recurrence.Conclusion As a safe and minimally invasive procedure,which leads to less trauma and pain,as well as quick recovery,TEP is especially suitable for patients with recurrent or bilateral hernias.

Objective To study the value of three dimensional contrast enhanced subtraction MRA (3D CES MRA) in the diagnosis of extremity musculoskeletal diseases. Methods Fifteen cases of extremity musculoskeletal diseases proved by operation and pathology were studied, including upper extremity ( n =5), lower extremity ( n =10), soft tissue and vascular lesions ( n =8), and skeletal lesions ( n =7). All examinations were performed with GE 1.5 T MRI scanner. Sagittal scout images were obtained by 2D FMPSPGR sequences. Before and after contrast enhancement, coronal 3D FSPGR sequence was performed in the same parameters within 32 seconds. The plain source images were subtracted by enhanced source images in the workstation. The subtracted images were processed by MIP technique, such method is so called 3D CES MRA. Results All lesions were demonstrated accurately by 3D CES MRA, including vascular lesions ( n =6), tumors in the soft tissue ( n =3), benign skeletal tumors ( n =1), and malignant skeletal tumors ( n =3). Compared with pathology, the diagnosing accuracy rate of 3D CES MRA was more than 90%. Conclusion 3D CES MRA is an advanced, safe, and noninvasive method in diagnosing extremity musculoskeletal diseases, further more, it can save time and resources. In general, 3D CES MRA has a great value in clinical application.