Objective To study the effects of irbesartan and amlodipine on blood pressure variability (BPV) by observation of irbesartan and amlodipine in treatment of essential hypertension before and after the change of blood pressure.Methods 119 hypertensive patients were randomly divided into group A and group B according to age,sex, blood pressure,left ventricular mass index.60 patients were treated with irbesartan (group A),and another 59 patients were treated with amlodipine(group B).Liver and kidney function,blood glucose,cholesterol,low density lipoprotein,24h systolic blood pressure variation coefficient (24SCV),coefficient of variation of daytime systolic (dSCV),night systolic blood pressure variability index (nSCV),24h diastolic blood pressure coefficient of variation (24DCV),day-time diastolic blood pressure variability (dDCV),nocturnal diastolic blood pressure variation coefficient (nDCV),left ventricular mass index (LVMI),urine micro albumin,carotid intima -media thickness (IMT)level were examined at the 24th week of the therapy.Results (1 )The levels of 24h SCV,dSCV,nSCV after treatment were significantly lower than before treatment both in group A and group B (group A:24hSCV t =4.42;dSCV t =3.46;nSCV t =4.70, group B:24hSCV t =3.93;dSCV t =2.38;nSCV t =5.00,all P <0.01).Comparison of BPV between group A and group B after treatment,the 24hSCV,dSCV,nSCV of group A were lower than those of group B(24hSCV t =3.16;dSCV t =2.95,;nSCV t =2.26,all P <0.05).(2)The levels of 24hDCV,dDCV,nDCV after treatment were signifi-cantly lower than before treatment both in group A and group B(group A:24hDCV t =9.96;dDCV t =3.31;nDCV t =5.93,all P <0.01;group B:24hDCV t =5.38;dDCV t =2.19;nDCV t =5.76,all P <0.01).Comparison of BPV between group A and group B after treatment,24hDCV,dDCV,nDCV of group A were lower than those of group B (24hDCV t =2.42;dDCV t =1.44;nDCV t =2.45,all P <0.05).(3)The level of LVMI after treatment was signifi-cantly lower than before treatment both in group A and group B (group A:t =8.11,P <0.01;group B:t =7.28,all P <0.01).Comparison of LVMI between group A and group B after treatment,the LVMI of group A was lower than that of group B(t =3.75,P <0.01).(4)The level of urine micro albumin after treatment was significantly lower than before treatment both in group A and group B (group A:t =25.04;group B t =11.59,all P <0.01).Comparison of urine micro albumin between group A and group B after treatment,the level of group A was lower than that of group B (t =8.23,P <0.01).(5)The level of IMT after treatment was significantly lower than before treatment both in group A and group B (group A:t =5.58;group B t =4.10,all P <0.01).Comparison of IMT between group A and group B after treatment,the level of group A was lower than that of group B(t =1.98,P <0.05).Conclusion Irbesartan and amlodipine both can effectively reduce blood pressure and BPV.They both can protection of target organs in patients with hypertension.Irbesartan is better than amlodipine.

OBJECTIVE:To compare amiodarone and cedilanid in the treatment of paroxysmal atrial fibrillation(AF) with intravenous administration and control of heart rate.METHODS:47 AF patients were randomly given 150～600 mg amiodarone(amiodarone group,n=24) and 0.2～0.6 mg cedilanid(cedilanid group,n=23) intravenously.The outcome,change of heart rate and adverse drug reaction of 2 groups were observed.RESULTS:Effective rate of amiodarone group was significantly higher than that of cedilanid groups(P

AIM: To explore the characteristics of motor evoked potential(MEP) and cortical excitability in Parkinson's disease by transcranial magnetic stimulation(TMS).METHODS: 20 normal volunteers were enrolled as control(group A),with the average age of(62.3?16.7) year old ranged from 52 to 79 years including 12 males and 8 females.MEP were assessed and compared separately between left and right hemispheres.21 patients with Parkinson's disease(PD) in asymmetry symptoms were performed in this study(group B),with the average age of(63.3?16.7) year old ranged from 46 to 80 years including 12 males and 9 females.UPDRS motor scores(UPDRSⅢ) were assessed before the check of cortical excitability(MEP).Motor evoked potentials(MEP) was assessed and compared separately on the minor and the serious bodyside,compared to control group.RESULTS: The indexes of MEP from both sides of normal control had no significant diversity.Amp was increased and both rest motor threshold(RMT) and cortical latency(CL) were also decreased significantly in PD patient compared to the normal control.On the serious side of PD,RMT decreased significantly compared to the minor side.Amp,CL and central motor conduct time(CMCT) changed without significant diversity between minor and serious bodyside.CONCLUSION: The motor cortical excitability is increased in PD patients.The excitability is higher with the more serious symptom side.The character of MEP in PD patients may be helpful to make a diagnosis and evaluate the severity of symptoms.

Humans ; Melanoma/therapy* ; Skin Neoplasms/therapy* ; Methylation ; Prognosis ; Immunotherapy ; RNA ; Biomarkers, Tumor ; Melanoma, Cutaneous Malignant