Objective To investigate the effect of microminiature water halloon combined with misoprostol per rectum for delivery of full-term pregnancy. Methods 305 full-term pregnant women with planned delivery were divided into three groups at random.The observation group (n=99) was given microminiature water balloon combined with misoprostol per rectum.The first control group (n=96) was only given misoprostol per rectum. The second control group (n=110) was given 0.5% oxytocin in a continuous infusion.Their results were taken a com-parative study,including the cervical ripening,dilivery process,delivery ways and the condition of the newbom. Results The observation group was better than other groups for cervical ripening(P<0.00).Tune from induction to the onset of regular contraction activity of the uterus in the observation group was significantly shorter than other groups (P<0.00).The rates of cesarean section and the total stage of lahor between the observation and the first control group were not statistically significant(P>0.05),but they were significantly different from the second con-trol group.There were no significant differences among the groups in neonatal asphyxia and amount of postpartum blood loss. Conclusions The efficiency of microminiature water balloon combined with misoprostol per rectum for delivery of full-tarm pregnancy was better than other groups.It has a short delivery process and shows no side effects on both mother and fetus,which is worthy of popularizing in obstetrics.