Objective: To investigate the characteristics of brain laterality in patients with childhood onset schizophrenia. Methods: The study employed a dichotic Chinese word listening test(DL) as a chief measure and WISC-R as an assistant measure to examine 16 patients and 20 normal children as controls. Results: DL indicated that the patients differed from the controls in ear advantages and their performances were significantly poorer than the controls in left ear. The performances of the patients on WISC-R showed that their PIQ was significantly lower than VIQ. Conclusion:The patients with childhood onset schizophrenia differed from the controls in brain laterality. They might be involved with right hemisphere impairment.

Osteoporosis is a common metabolic bone disease, which is involved in disrupted normal bone remodeling process and bone resorption exceeding bone formation. Osteoblasts and osteoclasts play critical roles in maintaining bone homeostasis. In recent years, more and more studies have found that immune cells are involved in the regulation of osteoblast and osteoclast activity via releasing various chemokines and cytokines, and the concept of immunoporosis has been proposed accordingly. This article summarizes the current state of knowledge on the immune system in the pathophysiology of osteoporosis, so as to study and prevent osteoporosis from the perspective of immunology.

At present the parkinsonian rigidity assessment depends on subjective judgment of neurologists according to their experience. This study presents a parkinsonian rigidity quantification system based on the electromechanical driving device and mechanical impedance measurement method. The quantification system applies the electromechanical driving device to perform the rigidity clinical assessment tasks (flexion-extension movements) in Parkinson's disease (PD) patients, which captures their motion and biomechanical information synchronously. Qualified rigidity features were obtained through statistical analysis method such as least-squares parameter estimation. By comparing the judgments from both the parkinsonian rigidity quantification system and neurologists, correlation analysis was performed to find the optimal quantitative feature. Clinical experiments showed that the mechanical impedance has the best correlation (Pearson correlation coefficient = 0.872, < 0.001) with the clinical unified Parkinson's disease rating scale (UPDRS) rigidity score. Results confirmed that this measurement system is capable of quantifying parkinsonian rigidity with advantages of simple operation and effective assessment. In addition, the mechanical impedance can be adopted to help doctors to diagnose and monitor parkinsonian rigidity objectively and accurately.