Objective To study the distribution of rare blood groups in Chinese populations.Methods The authors detected Di b-and Wr b-(Diego),Tja-(P),Jk(a-b-)(Kidd),K+ and K 0 (Kell),Mur+(Miltinberger),Ge-(Gerbich) and Ena-(MNS) using monoclonal,polyclonal antibodies and urea with IAT and U type 96 well microplate technology.Results One Di(a+b-)was found out of 645 donors,6 Mur + out of 900 donors,7 K+ out of 10057 donors,2 Jk (a-b-) out of 48400 donors and no Wr b-,K 0,Ge-,Ena-phenotypes were found among 4000 random donors.Conclusion The frequencies of Di b-,Mur+,Jk(a-b-)in Chinese are higher than those in Caucasian and black people.