ObjectiveToinvestigatetheriskfactorsforunfavorableoutcomeinpatientswithminor ischemic stroke. Methods Patients with minor ischemic stroke were enroled prospectively. The modified Rankin Scale ( mRS ) w as used to assess the clinical outcome at day 90 after onset, and mRS 0-2 w as defined as favorable outcome. The demographic data, vascular risk factors, clinical data, imaging data, stroke etiologic subtypes, laboratory test results, and treatment methods in the favorable outcome group and unfavorable outcome group w ere compared. Multivariate logistic regression analysis w as used to identify the independent risk factors for early poor outcome in patients w ith minor ischemic stroke. Results A total of 516 patients with minor ischemic stroke were enroled. At day 90 after onset, 90 patients (17.44%) had unfavorable outcome and 426 (82.56%) had favorable outcome. Multivariate logistic regression analysis showed that age (odds ratio [OR] 1.045, 95% confidence interval [CI] 1.017-1.074; P=0.002), heart diseases (OR 2.021, 95%CI 1.063-3.841; P=0.032), baseline National Institutes of Health Stroke Scale (NIHSS) score (OR 1.662, 95%CI 1.177-2.347; P=0.004), limb movement disorder ( OR 2.430, 95%CI 1.010-5.850; P=0.048), ataxia (OR 2.929, 95%CI 1.188-7.221;P=0.020), early neurological deterioration ( OR 50.994, 95%CI 17.659-147.258; P<0.001), infarct diameter ( OR 1.279, 95%CI 1.075-1.521; P=0.005), non-responsible vascular stenosis ( OR 2.518, 95%CI 1.145-5.536;P=0.022), and large artery atherosclerotic stroke ( OR 2.010, 95%CI 1.009-4.003; P=0.047) w ere the independent risk factors for unfavorable outcome in minor ischemic stroke. Conclusions The early poor outcome of minor ischemic stroke is closely associated w ith age, heart diseases, baseline NIHSS score, limb movement disorder, ataxia, early neurological deterioration, infarct diameter, non-responsible vascular stenosis, and large artery atherosclerotic stroke. The relevant examinations need to be improved early, the etiologic subtype should be identified, and the correct clinical treatment should be guided.

Objective To compare the efficacy and safety between Solitaire AB thrombectomy and intravenous thrombolysis in cardiogenic cerebral embolism.Methods Retrospective analysis of clinical data of 41 patients with cardiogenic cerebral embolism,admitted to our hospital from January 2012 to May 2015,was performed.According to different treatments,these patients were divided into Solitaire AB thrombectomy group (n=15) and intravenous thrombolysis group (n=26);patients in the Solitaire AB thrombectomy group were performed Solitaire AB thrombectomy,and patients in the intravenous thrombolysis group were given recombinant tissue plasminogen activator (rt-PA) or urokinase to achieve thrombolysis.Clinical outcomes were compared between two groups such as recanalization rates (thrombolysis in cerebral infarction [TICI] ≥ 2B),changes of NIHSS scores after 24 hours (scores decreased equal to or at least 4 points or complete resolution of symptoms),cerebral hemorrhage rate (European Cooperative Acute Stroke Study Ⅱ standard),modified Rankin scale (mRS) score improvement and mortality 90 days after treatment.Results In patients from Solitaire AB thrombectomy group,the recanalization rate was 86.67％ (13/15),10 patients (66.67％) got good outcomes in NIHSS scores,one patient (6.67％) occurred symptomatic cerebral hemorrhage;90 days after treatment,the rate of good prognosis (mRS 0-2) was 53.33％ (8/15) and no patients died.In patients from intravenous thrombolysis group,the recanalization rate was 46.15％ (12/26),9 patients (34.62％) got good outcomes in NIHSS scores,1 1 patients (42.31％) occurred symptomatic cerebral hemorrhage;90 days after treatment,the rate of good prognosis (mRS 0-2) was 23.08％ (6/26) and 8 patients (30.77％) died.The above data comparisons between two groups were statistically significant (P＜0.05).Conclusion As compared with intravenous thrombolysis,Solitaire AB thrombectomy has better efficacy and safety in the treatment of cardiogenic cerebral embolism.

Objective To study the clinical effect of massage therapy on infants and young children with asthmatic disease.Methods 100 infants and young children with asthmatic disease were selected.The children and parents who agreed to cooperate with massage therapy were enrolled as treatment group.The children and parents who were unwilling to cooperate with massage therapy,but willing to cooperate with home aerosol therapy were enrolled as control group,50 cases in each group.The two groups of children took comprehensive treatment measures,the treatment group was given massage therapy,the control group was given home aerosol therapy.The therapeutic effects of the two groups were compared and analyzed.Results The respite time,recurrent frequency of wheezing within 1 year,respiratory infection occurred within 1 year,number of re-hospitalization within 1 year of the control group were (5.6 ± 1.36) d,(2.35 ± 1.13) times,(2.96 ± 1.22) times,(0.85 ± 0.58) times,which of the treatment group were (5.82 ± 1.44) d,(2.31 ± 1.09) times,(2.89 ± 1.19) times,(0.86 ± 0.51) times,the differences were not statistically significant between the two groups (t=0.573,0.417,0.523,0.872,all P ＞0.05).The peak time before treatment,1 month after treatment and 6 months after treatment,and the peak volume ratio before treatment,1 month after treatment and 6 months after treatment between the two groups had no statistically significant differences(all P ＞ 0.05).Conclusion Massage therapy can achieve the same effect with the home aerosol therapy,the method is simple,easy,without any adverse reactions,it is worthy of clinical promotion.