1.A Study of PTSD and Its Risk Factors among Adult in Flood District
Zhigang WU ; Aizhong LIU ; Hongzhuan TAN
Chinese Journal of Clinical Psychology 2001;0(03):-
Objective:To explore the incidence of PTSD and its risk factors among adults in flood district.Methods:Diagnostic and Statistical Manual of Mental Disorders(Ⅳ Edition) were used to examine and diagnose the victims.Results:The positive rate of PTSD was 33.8%.The results of logistic regression analysis showed that style of flood (OR=4.07),having been besieged by the flood when waiting for resue(OR=2.65),seeing other people drowned by flood(OR=2.77),having the experience of staying with the dead in flood(OR=3.14) and level of satisfaction with sustaining(OR=0.72) were risk factors.Conclusion:PTSD is a not uncommon mental disorder among adults in flood district in our country and psychosocial intervention is needed.
2.Relationship between personality traits and prognosis of posttraumatic stress disorder in flood survivors
Xin WU ; Long CHEN ; Wenjie DAI ; Hongzhuan TAN ; Aizhong LIU
Chinese Mental Health Journal 2017;31(4):268-273
Objective:To explore the prognosis of posttraumatic stress disorder (PTSD) in flood survivors 13 years after they had been diagnosed with PTSD symptoms,and investigate the relationship between their personality traits and the prognosis of PTSD.Method:In this cross-sectional study,the survivors of Dongting Lake flood in 1998-1999 in Hunan in China,who were investigated and screened as PTSD symptoms positive in 2000 were selected as the target population,from which a sample of 200subjects was drawn using amulti-stage random sampling method.The Posttraumatic Stress Disorder Scale Civilian Version (PCL-C) was used to examine and re-screen the participants of PTSD symptoms in order to explore the prognosis of PTSD.Participants whose PCL-C scores were equal to 44 or higher were classified as the PTSD symptoms positive group,while those with PCL-C scores less than 44 were classified as the recovered group.Personality traits were then assessed,using the Revised Eysenck Personality Questionnaire Short Scale for Chinese (EPQ-RSC),in both the recovered group and the PTSD symptoms positive group.Finally,the multivariate logistic regression analysis was used to investigate the relationship between the prognosis of PTSD and personality traits.Results:Totally 200 subjects were eligible for this study and completed the questionnaires,but 16 of them had their questionnaires excluded from data analysis because they provided incomplete information.Thus,the response rate was 92.0%.According to the PCL-C's cut-off score,22 participants were still screened as PTSD symptoms positive and were classified as the PTSD symptoms positive group,whereas the other 162 participants were screened as PTSD symptoms negative and were classified as the recovered group.Compared with the recovered group,the EPQ-RSC extroversion scores for the PTSD symptoms positive group were significantly lower [(51.8 ± 10.7) vs.(45.1 ± 13.2),P < 0.05] and their neuroticism scores were significantly higher [(46.5 ± 10.1) vs.(58.3 ± 12.2),P < 0.05].The multivariate logistic regression analysis showed,after adjusting for the variables such as gender and age,that higher neuroticism (OR = 3.63,95% CI:1.05 -12.54) was a risk factor for the persistent PTSD symptoms in the flood survivors.Conclusions:It suggests that neuroticism is associated with prognosis of PTSD in flood survivors,those with higher neuroticism scores appear to have problems to recover from PTSD.
4.Effect of EMG-electrical Stimulation on Upper Extremity Function in Patients with Hemiplegia after Stroke
Guowei ZHANG ; Lixin SHI ; Hongzhuan WU ; Bing CHEN
Chinese Journal of Rehabilitation Theory and Practice 2007;13(6):544-545
Objective To investigate the effect of EMG-electrical stimulation on upper extremity function in patients with hemiplegia after stroke.Methods52 stroke patients with hemiplegia were randomly divided into the EMG-electrical stimulation group (27 cases) and control group (25 cases). All patients of two groups were treated with routine therapy and regularly physical therapy and occupational therapy, while those of the EMG-electrical stimulation group were given EMG-electrical stimulation training. The active range of motion (AROM) of wrist dorsiflexion was evaluated and upper extremity function was assessed by Fugl-Meyer Assessment (FMA) pre-treatment and 2 months after treatment.ResultsThe upper extremity function of all patients in two groups improved and the patients of the EMG-electrical stimulation group were superior to those of the control group ( P<0.05). The AROM and FMA scores of the patients in the EMG-electrical stimulation group were significantly superior to that of the patients in the control group ( P<0.05).ConclusionThe EMG-electrical stimulation can improve the upper extremity function of hemiplegic patients after stoke.
5.Protective effects of high concentration fentanyl on brain slice injury induced by oxygen glucose deprivation
Yongjun ZHENG ; Xiangrui WANG ; Xingjun WU ; Hongzhuan CHEN ; Yanhua ZHAO ; Diansan SU ; Zhiying PAN
Chinese Pharmacological Bulletin 2003;0(10):-
Aim To investigate the protective effects of high concentration fentanyl on the brain slice injury induced by oxygen glucose deprivation(OGD).Methods Rat brain slices were made and randomly assigned to four groups:control(n=10),OGD(n=10),fentanyl 50 ?g?L~(-1)(F_(50),n=10) and fentanyl 500 ?g?L~(-1)(F_(500),n=10).Changes of the neuron injury and apoptosis were observed with TTC staining,LDH releases,TUNEL staining,immunohistochemistry and electromicroscope.In addition,changes of intracellular calcium were measured with confocal laser-scanning microscopy.Results F_(50) and F_(500) attenuated the decrease of TTC staining and the increase of LDH release induced by OGD in brain slices.Neuronal apoptosis and changes of neuronal ultrastructures were attenuated by F_(50) and F_(500).Bcl-2 and Bax protein expressions were increased after OGD.Bax protein expression was decreased by F_(50) and F_(500),while Bcl-2 protein expression was increased by F_(50)and F_(500).Intracellular calcium concentration was increased by OGD and then it was lowered by F_(50) and F_(500).The protective effects of F_(50) were more obvious than that of F_(500).Conclusions High concentrations of fentanyl have neuron protective effects against OGD injury in rat brain slices,and fentanyl 50 ?g?L~(-1) has more obvious protective effects than fentanyl 500 ?g?L~(-1).
7.Research progress on etiology of gestational diabetes mellitus
Jiayue ZHANG ; Shujuan MA ; Chuhao GUO ; Sisi LONG ; Shilan WU ; Hongzhuan TAN
Global Health Journal 2018;2(4):19-27
As a metabolic disorder during pregnancy,gestational diabetes mellitus (GDM) has an important effects on fetal development,neonatal health and maternal long-term health,and is one of the pregnancy complications with high incidence.It is of great significance that we have an accurate understanding of the etiology and risk factors of GDM for its prevention and control.GDM is a complex disease with multiple etiologies.Current studies have shown that the occurrence of GDM may be the result of combined effect of heredity and environment,but the exact etiology is still unclear.In this paper,we summarized the possible etiologies and risk factors of GDM,so as to understand the occurrence and development of GDM better and to provide possible references for prevention and further etiological studies of GDM.
8.Morphometry of osteoclasts in experimental fracture healing of rabbits.
Jiaqi WU ; Yuanying WU ; Yiwei JIANG ; Hongzhuan LI ; Xiaogang ZHANG ; Tianfu YANG
Journal of Biomedical Engineering 2007;24(4):889-893
This study was designed to investigate the effects of some Traditional Chinese Medicine (TCM) agents on bone resorption and morphometric features of osteoclasts as well as their relationships. TCM ShengGuZaiZaoSan and XianLingGuBao, were used to treat the experimental fracture. Thirty 6-month-old Chinchilla rabbits were used for the establishment of animal models each with a 3 mm bone defect in the middle of left radius as well as of right radius. These models were divided randomly into 3 groups : ShengGuZaiZaoSan Group (Group A), XianLingGuBao groups (Group B) and control-group (Group C). Every group was further divided into 2 subgroups: a former sacrificed group (14 days after operation) and a latter sacrificed group (31 days after operation). After the rabbits being killed, the samples of their undecalcified calli were subjected to the morphometry study of bone resorption and osteoclasts. Group A had more bone resorption, compared with Group B and C. Both Groups A and B exhibited some changed morphometric features of osteoclasts as compared with Group C (P < 0.05). Simple correlation analysis indicated that bone resorption is mainly correlated with osteoclast numbers, and that in individual group, bone resorption is correlated with osteoclast form factor, area and mean photodensity (P < 0.05). These allow us to conclude that ShengGuZaiZaoSan can increase bone resorption and accelerate bone remodeling by increasing osteoclast numbers at the former stage and can enhance osteoclast function at the latter stage. These changes are beneficial to fracture healing.
Animals
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Bone Remodeling
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drug effects
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Bone Resorption
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physiopathology
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Drugs, Chinese Herbal
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pharmacology
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therapeutic use
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Female
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Fracture Healing
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drug effects
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physiology
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Male
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Osteoclasts
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drug effects
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pathology
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Phytotherapy
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Rabbits
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Radius Fractures
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drug therapy
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pathology
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physiopathology
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Random Allocation
9. A new mediation analysis method for multiple mediators
Chuhao GUO ; Shilan WU ; Shujuan MA ; Jiayue ZHANG ; Sisi LONG ; Hongzhuan TAN
Chinese Journal of Epidemiology 2019;40(9):1155-1158
Mediation analysis is mainly used to explore the causal mechanism between independent variable X and dependent variable Y. It determines whether mediator M plays a role and evaluate the role’s degree in the causal path by decomposing the causal path between the independent variable X and the dependent variable Y. However, the classical mediation analysis is generally used for single mediator. This paper introduces a new mediation analysis method for multiple mediators.
10.Modified Delphi method in the constitution of school sanitation standard.
Xunqiang YIN ; Ying LIANG ; Hongzhuan TAN ; Wenjie GONG ; Jing DENG ; Jiayou LUO ; Xiaokang DI ; Yue WU
Journal of Central South University(Medical Sciences) 2012;37(11):1104-1107
OBJECTIVE:
To constitute school sanitation standard using modified Delphi method, and to explore the feasibility and the predominance of Delphi method in the constitution of school sanitation standard.
METHODS:
Two rounds of expert consultations were adopted in this study. The data were analyzed with SPSS15.0 to screen indices of school sanitation standard.
RESULTS:
Thirty-two experts accomplished the 2 rounds of consultations. The average length of expert service was (24.69 ±8.53) years. The authority coefficient was 0.729 ±0.172. The expert positive coefficient was 94.12% (32/34) in the first round and 100% (32/32) in the second round. The harmonious coefficients of importance, feasibility and rationality in the second round were 0.493 (P<0.05), 0.527 (P<0.01), and 0.535 (P<0.01), respectively, suggesting unanimous expert opinions. According to the second round of consultation, 38 indices were included in the framework.
CONCLUSION
Theoretical analysis, literature review, investigation and so on are generally used in health standard constitution currently. Delphi method is a rapid, effective and feasible method in this field.
China
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Delphi Technique
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Feasibility Studies
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Hygiene
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standards
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Public Health Administration
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methods
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Schools
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standards