Objective To evaluate the efficacy of reinforcing kidney and removing stasis combined with thalidomide in the treatment of multiple myeloma.Methods 120 patients with multiple myeloma from January 2011 to January 2015 in department of traditional Chinese medicine of the third hospital affiliated to Liaoning medical university were divided into two groups.The control group received VAD program ( vincristine, doxorubicin and dexamethasone), and the observation group received reinforcing kidney and removing stasis combined with thalidomide on the basis of control group.All patients received treatment for four weeks of one course.Results After treatment, the total efficiency of observation group was higher than that of control group(75% vs.60%, P<0.05).Compared with control group, the M protein,plasmocyte count and osteoclasts count of observation group were lower, the osteoblast count of observation group was higher(P<0.05).The improvement rate of quality of life (KPS score) in observation group was higher than that in control group (70.00% vs.51.67%,P<0.05).The changes of renal function (serum creatinine, urea nitrogen) and adverse reaction in observation group were less than those in control group (P<0.05).Conclusion The reinforcing kidney and removing stasis combined with thalidomide has the significant effect in the treatment of multiple myeloma with fewer adverse reactions and higher quality of life after treatment.

Objective: To investigate the secondary metabolites from Chinese marine Sponge Cinachyrella australiensis. Methods: Column chromatography techniques including HPLC were used for the separation and purification of the compounds, and extensive spectral analyses including various 2D NMR spectra were employed for structure elucidation. Results: Nineteen compounds were obtained ,including 2 methyoxy 6,12,15 trien 8 yne octadecanoic acid(1), 2 benzenedicarboxylic acid dibutyl ester(2), 1,2 benzenedicarboxylic acid bis(2 ethylhexyl)ester(3), ( ) (3S) 1,2,3,4 tetrahydro ? carboline 3 carboxylic acid(4), L Tryptophan (5), p hydroxylbenzaldehyde (6), p hydroxyl benzylethanol(7), p hydroxyl benzyl propanol(8), cholesta 4 en 3 ol(9), 2 methyl 6 amino 9 (2 deoxy ? D ribofuranosyl purine(10), 2' Deoxyadenosine (11), 6 amino 9 ? D ribofuranosyl 9H purine (12),uracil(13), thymine(14), thymidine(15), 1 (2 deoxy ? D Ribofuranosyl)uracil(16), 1 ethyl ? (2 deoxy) ? D ribofuranos(17),isolumichrome(18),and zarzissine(19).Conclusion:Compounds 1 and 18 are new natural products,and compounds 2 to 17 as well as 19 are isolated from this species for the first time.

From 95% alcohol extract of Ascidian Styela clava, collected from the shallow bay near Qingdao City, Shandong Province, six compounds, named, isovaleramide (1), thymine (2), thymidine (3), uracil (4), 2'-deoxyuridine (5) and ?-palmityl glycerin ether (6) were isolated,. Their structures were elucidated by various spectral analysis (IR, MS, ~1HNMR, ~(13)CNMR) and comparison of chemical and physical data with authentic samples reported in literatures. All of these compounds are first reported to be isolated from Ascidian Styela clava.

Objective To investigate the trait coping styles, emotional intelligence, positive mental characters and the impact of event among Chinese recruits, and the relationship among them. Methods The Trait Coping Style Questionnaire (TCSQ), Schutte's Emotional Intelligence Scale (SSEIS), Positive Mental Characters Scale for Recruits (PMCS-R), and Impact of Event Scale-Revised (IES-R) were used to assess the coping styles, emotional intelligence, positive mental characters and the impact of event in 1 837 male recruits that were divided into two groups (stress group and control group) by considering the scores of the IES-R as the screening criteria (≥35). The data were analyzed by t test, correlation analysis and multiple stepwise regression analysis. Results Totally 148 (8.1%) male recruits with stress were screened, and 163 male recruits without stress were selected using stratified random sampling according to demographic characteristics of age, education level and so on. There were significant differences between stress and control groups in the scores of TCSQ, SSEIS and PMCS-R except utilization of emotions and wisdom. Multiple stepwise regression analyses showed that the negative coping, regulation of emotion and wisdom entered the regression equation of the total score of IES-R in the stress group (F=13.395, R2=0.218, P<0.05). However, in the control group, only negative coping came into the equation of the total score of IES-R (F=22.887, R2=0.155, P<0.05). Conclusion Trait coping styles, emotional intelligence and positive mental characters can predict the impact of stress event among recruits effectively, which could provide theoretical basis for the mental health service in recruits.

Object Isolation and structural identification of xanthone derivative from medicinal plant Swertia mileensis T N Ho et W L Shih were carried out Methods The chemical constituents were isolated and purified by extensive silica gel column chromatography and their structures were elucidated by chemical evidences and spectral analysis Results There were 12 xanthone analogues named 1 hydroxy 2, 3, 4, 5 tetramethoxyxanthone, (Ⅰ); 1 hydroxy 2, 3, 7 trimethoxyxanthone, (Ⅱ); 1 hydroxy 2, 3, 5, 7 tetramethoxyxanthone, (Ⅲ); 1, 5 dihydroxy 2, 3 dimethoxyxanthone, (Ⅳ); 1, 5 dihydroxy 2, 3, 7 trimethoxyxanthone, (Ⅴ); 1 hydroxy 2, 3, 5 trimethoxyxanthone, (Ⅵ); 1, 5 dihydroxy 2, 3, 4, 7 tetramethoxyxanthone, (Ⅶ); 1, 8 dihydroxy 2, 3, 6 trimethoxyxanthone, (Ⅷ); 1 hydroxy 2, 3, 4, 7 tetramethoxyxanthone, (Ⅸ); 1, 2, 3, 5 tetromethoxyxanthone, (Ⅹ); 1 hydroxyl 2, 3, 4, 6 tetramethoxyxanthone, (Ⅺ); 1 hydroxyl 2, 3, 6, 8 tetramethoxyxanthone, ( ⅩⅡ ) Conclusion Compounds Ⅰ, Ⅲ, Ⅳ, Ⅴ, Ⅶ ⅩⅡ were first isolated from S. mileensis

Objective To study the relationship between psychological health and social support and coping style in general hospitals. Methods 756 nurses from 3 general hospitals were enrolled by cluster sampling and were investigated by Symptom Checklist 90(SCL-90),Social Support Rate Scale(SSRS)and Simplified Coping Style Questionnaire(SCSQ).The investigation results were analyzed. Results The general level of psychological health of nurses was not optimistic with a positive rate Of 37.04％. The somatizatlon factor of the head nurses was different from that Of normal nurses. Significant difference existed in the following aspects such as somatization, depression and terror factors between night shift nurses and day shift nurses. Relativity could be seen between social support and coping style and psychological health. Conclusion Hospital managers should attach importance to the psychological health of nurses. At the same time they should supply positive social support and instrucitons of coping style to improve the general level of psychological health.

Objective To explore the mediating effect and moderating effect of positive mental characters in the relationship between childhood abuse and depression among recruits.Methods 1925 recruits aged from 16 ～24 were investigated using the Childhood Trauma Questionnaire-28 item Short Form (CTQ-SF),Self-Rating Depression Scale (SDS) and Positive Mental Characters Scale for Recruits (PMCS-R) through random cluster sampling.Results The scores of emotional abuse,physical abuse,sex abuse,emotional neglect,physical neglect,depression,positive mental characters were 6.11±1.69,5.49±1.32,5.61±1.45,9.15±3.66,9.57±2.93,0.45±0.11,3.80±0.64,respectively.There were correlations among childhood abuse,depression and positive mental characters (P＜0.05).Emotional neglect,physical neglect and emotional abuse could explain 28.6％ of the total variance of depression (F=256.72,P＜0.05).The positive mental characters partially mediated the relationship between emotional neglect,physical neglect,emotional abuse and depression (mediating effect were 0.19,0.15 and 0.09,respectively),and it could only moderate the relationship between emotional neglect and depression (F=24.73,P＜0.05).Conclusion Childhood abuse not only directly but also indirectly affects depression through the positive mental characters;meanwhile the positive mental characters can change the relationship between childhood abuse and depression.

Roles of sympathicus, sensory neuropeptides (SNP), metabolites of cyclooxygenase, metabolites of lipoxygenase, endothelium derived relaxing factor (EDRF), reactive oxygen (ROS) and potassium channels (PC) in the hypoxic pulmonary vasoconstriction (HPV) and hypoxic cerebral vasodilation (HCVD) were studied in intact rats, rabbits and dogs. Results were as follows: during hypoxia, the excitation of sympathicus results in a constriction of both pulmonary and cerebral vessels; SNP, EDRF and the opening of 4-AP sensitive PC caused the dilation of both of them; metabolites of lipoxygenase mediated HPV and HCVD, whereas metabolites of cyclooxygenase were their modulators; hypoxia induced blockade of the ATP sensitive PC mediated HPV, but had no effect on HCVD; reduction of O_2~+ in the lung might potentiate HPV, but had no effect on HCVD. It is suggested that the alteration of lipoxygenase metabolites, ROS and ATP sensitive PC are factors accounting for the difference in response of pulmonary and cerebral vassels to hypoxia.

Objective To explore sleep quality and related psychological factors among young army cadres to provide theoretical basis for health interventions. Method A total of 1 100 young army cadres aged 18 to 34 were assessed with Pittsburgh sleep quality index (PSQI), Symptom Checklist-90 (SCL-90) and Center for Epidemiologic Studies Depression Scale by cluster random sampling. Based on CES-C scores, cadres were divided into two groups named depression group and non-depression group;850 sergeants were served as the control group. T test, chi-square test and multiple regressions were used in data analysis. Result Sleep problems were found in 13.5% of the cadres and 12.1% sergeants. General status of sleep quality of cadres was worse than sergeants' and norm's. Exercise less, physical disease and psychological problems were the risk factors. Multiple stepwise regression analysis showed that depression factors of SCL-90 had the most significantly predictive effect on sleep quality (r=0.552, Beta=0.387), followed by somatization (r=0.552, Beta=0.223), two factors could explain 32.7% of PSQI scores variation. Correlation analysis showed that depression is closely related to subjective sleep quality, sleep duration, sleep disorder and daytime dysfunction (all r>0.3). Cadres' depression (11.11 ± 6.62) was significantly lower than norm's (12.30 ± 10.39) and higher than sergeants'(8.11 ± 6.56). PSQI scores of depression group (6.05 ± 3.13) were significantly higher than non-depression group's (3.56 ± 2.69) and norm's (3.23 ± 3.12). Conclusion Depression is a major correlation factor of the sleep quality. Regular exercise, improvement of the physical and psychological health quality, and reducing depression are effective ways to improve sleep quality.

Objective To investigate the related risk factors caused the retained common bile duct (CBD)stones after laparoscopic cholecystectomy,to provide the evidence for preventing from retained common bile duct stones of laparoscopic cholecystectomy.Methods Selected 654 cases of laparoscopic cholecystectomy patients as the objects whom hospitalized in Beijing Chuiyongliu Hospital from January 2002 to June 2013.All cases were divided into the group of retained CBD stones (27cases) and the group of non-retained CBD stones (627 cases).Collected the potentially relevant factors of two groups with the retained CBD stones,including medical history of jaundice and pancreatitis,common bile duct internal diameter (B Ultrasound) ≥ 8 mm,acute cholecystitis,emergency surgery,gallbladder removal order,calot triangle adhesion,sludge calculus,stones neck incarcerated,fulltype stones,cystic duct thickening,cystic duct reserved≥ 1 cm,the minimum diameter stones ≤5 mm,the number of gallbladder stones ≥ 5,partial cholecystectomy,purulent bile.Statistics analyses was proceeded using the IBM SPSS 20.0.Result Through dichotomy logistic regression analysis to the univariate analysis results with statistical significance,sorted the results according to the influence degree,found the independent risk factors:common bile duct internal diameter (B Ultrasound) ≥8 mm,gallbladder removal order (retrograde removal),medical history of jaundice pancreatitis,cystic duct reserved ≥ 1 cm,sludge calculus,in total of 5 indexes,which caused the retained CBD stones after laparoscopic cholecystectomy.Conclusion There are several independent risk factors for retained CBD stoes after LC such as medical history of jaundice and pancreatitis,common bile duct internal diameter (B Ultrasound) ≥ 8 mm,the order of cholecystectomy (retrograde remoral),shudeg calculus and the remaining length of bile duct ≥ 1 cm.The surgeons should pay close attention to them and take appropriate measures in the preoperation and intraoperation of LC,which contribute to preventing the acurence of postoperative retaimed CBD stone.