Objective To study the glycosylated hemoglobin in the level difference between different age,sex and provide a reference for the prevention,early diagnosis and treatment of diabetes.Methods 9 094 cases in clinic of population data were included in this study,according to the different age groups were divided into 30 years old or less group (464 cases),30 ～40 years old group (715 cases),41～50 years old group (1 939 cases),51～60 years old group (1 754 cases),61～ 70 (2 290 cases),71～80 years old group (1 497 cases) and ＞80 years old group (435 cases),7 groups of extraction of venous blood tested glycated hemoglobin and compared,analysis of glycosylated hemoglobin levels between different age groups and different gender differences.Results All subjects crowd glycosylated hemoglobin levels were ≤30 years old group (5.42± 0.841) ％,31 ～40 years old group (5.61 ± + 1.088) ％,41 ～ 50 years old group (5.93 ± 1.264) ％,51 ～ 60 years old group (6.18±1.298) ％,61～ 70 years old group (6.21 ± 1.232) ％,71 ～ 80 years old group (6.29 ± 1.270) ％,＞ 80 years old group (6.35 ± 1.314)％ all were a trend of increase with the increase of age,the difference was statistically significant(F=63.81,P＜0.001).The level of glycosylated hemoglobin was significantly higher in male than in female within 70 years of age,and there was significant difference in HbA1c level between 18～50 years old (P＜0.05).Conclusion There was a correlation between the level of glycosylated hemoglobin with different age,sex and increasing with age.It is suitable for physical examination and screening,and in particular,monitoring of glycosylated hemoglobin levels in middle aged and old age.

Objective Essential polyunsaturated fatty acids(PUFA) can not been synthesized by the body-self.Serum triglycerides n-6 and n-3 PUFAs directly or indirectly reflect the corresponding unsaturated fatty acids intake from meals.This study was to investigate the relationship of serum triglycerides polyunsaturated fatty acid composition with the ratio of n-6 to n-3 PUFA(n-6/n-3 PUFA) and magnetic resonance imaging measured intra-abdominal fat(MRI-IAF) with other body fat parameters of patients with metabolic syndrome.Methods Thirty-six patients with metabolic syndrome and 41 healthy controls were enrolled in this investigation.The relevance of serum triglycerides polyunsaturated fatty acids with MRI-IAF was observed.A stepwise regression analysis was applied to determine which kind of triglycerides polyunsaturated fatty acid could predict MRI-IAF,waist circumference and body mass index (BMI) more potent.Results In the metabolic syndrome group,blood sugar,lipid profiles,blood pressure,visceral fat accumulation-related parameters and serum triglycerides polyunsaturated fatty acid composition was worse than those in the control group.Compared with the healthy controls,n-6/n-3 PUFA was significantly increased(t=8.564,P＜0.05),although C18∶3 n-3,C20∶5 n-3(EPA),C22∶6 n-3(DHA) and n-3PUFA were significantly declined(t=-2.920,-7.034,all P＜0.05) in metabolic syndrome group.The difference of n-6 PUFA showed no statistically significant difference(t=-0.957,-1.494,P＞0.05).n-6/n-3 PUFA,n-3 PUFA,EPA and DHA were associated with MRI-IAF(r=-0.377,0.565,all P＜0.05); n-6/n-3 PUFA was correlated with the waist circumference(r=0.400,P=0.016) and BMI(r=0.357,P=0.033),while n6 PUFA showed no correlation with body fat parameters.N-6/n-3 PUFA was more potent to predict MRIIAF,waist circumference and BMI(adjusted R2=0.102,0.299,all P＜0.05) than other polyunsaturated fatty acids.Conclusions The ratio of n-6/n-3 PUFA and n-3 PUFA may be positively correlated with EPA and DHA could be inversely associated with MRI-IAF and other body fat-related parameters in patients with metabolic syndrome,while n-6 PUFA did not show such a relationship.The ratio of n-6/n-3 PUFA might be more potent to predict MRI-IAF and other body fat-related parameters.

Objective To analyze the distribution of syphilis infection, serological test results and HIV infection in inpatients of a general hospital in Chengdu, so as to provide effective theoretical basis for the effective prevention and treatment of syphilis. Methods To collect the clinical data of syphilis infected patients in a general hospital in Chengdu from January 2014 to October 2020.The syphilis infection rate of men and women in different age groups, the distribution of syphilis infection departments, the education level, industry and marriage of the infected people were analyzed.The Department Distribution of syphilis infection,and compare the positive rates of tpsab,TPPA and trust in syphilis infected patients,as well as the combined HIV infection rate in syphilis patients of different genders. Results From January 2014 to October 2020,206455 cases of syphilis were screened in our hospital,of which 4760 cases were infected with syphilis,accounting for about 2.31%;there were 2843 males and 1917 females,with a male to female ratio of 1.48:1;the age distribution of 41-50 years old was the most,followed by 51-60 years old,61-70 years old and 31-40 years old,and the age group of<21 years old was the least;and syphilis serological abnormalities were found in 31-40 and above 61 years old in female group The proportion of Syphilis Serological abnormality was lower than that of male(χ²=4.143,P=0.042;χ²=81.395,P<0.001;χ²=63.699,P<0.001;χ²=24.425,P<0.001),while the proportion of Syphilis Serological abnormality in 21-30 age group was higher than that of male(χ²=4.237,P=0.039).Department Distribution: the top five departments were neurology, anorectal hemorrhoids and fistula, gastrointestinal surgery, orthopedics and urology. Among the 4760 patients diagnosed with syphilis infection, the proportion of those with education level of junior high school or below, service industry and married was higher.The positive rates of tpsab and TPPA were significantly higher than those of trust(χ²=6293.760,P<0.001).Among the 4760 syphilis patients,the proportion of HIV infection in male group was higher than that in female group,and the difference was statistically significant(χ²=102.886,P<0.001). Conclusion The syphilis infection of inpatients in our hospital is mainly middle-aged and old men, low education, people engaged in service industry, and the common departments are neurology department. Therefore, the early popularization and screening of this kind of population is of great significance.

Targeted delivery of antibody bound to antigen is a precise drug delivery mode. It is regarded as one of the ideal targeted drug delivery modes due to its high specificity and affinity, which opens up a new way to successfully solve the problem of poor selectivity of chemotherapy drugs in antitumor therapy. Currently, the research on antibody drug conjugates(ADCs) that bind monoclonal antibodies to target antigens has become a research hotspot of molecular targeted therapy. This paper reviews the mechanism of action, targeting strategies and progress in the targeted delivery of ADCs, in order to provide reference for the clinical development of new ADCs.