[Objective] To explore the influence of nursing intervention in reducing cardiovascular risk factors in elderly patients with impaired glucose tolerance.[Methods] From May 2009 to June 2011,216 cases of elderly patients in the clinic of our hospital with impaired glucose tolerance were randomly divided into the intervention group and the control group with 108 cases in each.The control group adopted traditional routine care,and the intervention group received nursing intervention.The duration of followup and intervention was six months.The collected data included basic situation,and tested blood pressure,blood sugar,total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDLC)and low density lipoprotein cholesterol(LDL-C)before and after follow-up.[Results] For both two groups of patients,blood sugar levels were decreased,the decreased level in the intervention group was higher than that of the control group.[Conclusions] Nursing intervention for the elderly patients with impaired glucose tolerance plays a significant role in reducing cardiovascular risk factors and improving IGT prognosis.

Cerebral palsy, a non-progressive central dyskinesis caused by a variety of reasons. is one of the major diseases resulting in serious paralysis of children nervous system. At present there is no special treatment. and most are supporting and symptomatic treatments. In recent years, with development of recombinant DNA technology and cell biology. transgenic cell lines and cell line transplantation have become new focus of study in brain transplant. Currently the experimental studies on cell transplantation, especially stem cells. in the treatment of children cerebral palsy mainly refer to newborn animals with hypoxic-ischemic brain injury at acute phase. and have made some progresses. Studies have demonstrated that stem cells can survive longest for eight months after transplanted into the brain. and can migrate to the damage a/ca and differentiate into different phenotypes of nerve cells to improve partly neuroethology disorder. However. that transplanted stem cells differentiate into minimal target neurons may be ode of main reasons that cannot achieve ideal effects.

Breast cancer is a group of heterogeneous diseases.Molecular portraits provide a new insight for personalized cancer management in breast cancer.According to the molecular pathology,molecular biology and system biology,breast cancer goes through different typing methods,including four subclasses,geneexpression signature and integrated genomic classification.These major subtypes of breast cancer may provide guidance for precise therapeutics.

Objective To analyze the clinical features and results of array-comparative genomic hybridization (array CGH, aCGH) in a Chinese girl with Phelan-McDermid syndrome. Methods The clinical symptoms of a child with Phelan-Mc-Dermid syndrome were retrospectively analyzed. Routine G-banding was performed to analyze the karyotype, and the aCGH was used to analyze subchromosomal abnormalities. Results The routine karyotype analysis showed a normal female karyotype without abnomalities in chromosome number and structure. aCGH analysis finely mapped the deletion of Chr22q13.2-qter. Phel-an-McDermid syndrome was diagnosed for this case. Conclusions Phelan-McDermid syndrome can be diagnosed by the typi-cal and detailed clinical features in combination with the laboratory examinations of subchromosomal abnormalities. aCGH is one of the most valuable methods to analyze subchromosomal abnormalities and to diagnose Phelan-McDermid syndrome.

Cancer precision therapeutics is defined as a therapy strategy based on molecular profiles and classifiers generated from high-throughput molecular assays.Precision therapeutics in oncology is becoming reality thanks to the next-generation sequencing and cancer targeted agents.Selecting optimal targets,identif-ying appropriate combinations of therapies and real-time monitoring of tumor evolution may be critical for practi-cing precision therapeutics.

Maintenance therapy is an important strategy for cancer treatment,which mainly include continuation maintenance therapy and switch maintenance therapy,with a classical model of metronomic chemo-therapy.Maintenance therapy can be an effective treatment option for patients with non-small cell lung cancer, breast cancer,colorectal cancer and ovarian cancer.

In patients with initially diagnosed unresectable cancers,resection of cancer sometimes becomes possible by systemic chemotherapy,and this model of chemotherapy is defined as conversion chemo-therapy. Conversion chemotherapy can improve objective response rate and resection rate,and it has shown an important value in metastatic colorectal cancer,advanced gastric cancer and unresectable hepatocellular carci-noma.

Objective To investigate the etiology,clinical characteristics,diagnosis and treatment of female uterine empyema.Methods We retrospectively analyzed the clinical data of 31 patients with uterine empyema in our hospital from January 2003 to December 2015.Results Uterine empyema was caused as a result of occlusion of the cervical canal,Patients had no typical symptoms,four cases had no symptoms (12.90％),twenty-two cases had abdominal pain (70.97％),twenty-seven cases had vaginal discharge (98.09％) and twelve cases had sanguinopurulent material (38.71％),three cases of them had fever (9.70％).Gynecological ultrasound examination was an important diagnostic tool.Dilatation of cervix,discharging purulent material,antibiotics treatment,the cervical adhesions were manually broken down to establish a patent cervical lumen to accommodate a uterine Fleischl catheter,the uterus was lavaged with 0.9％ Nacl solution,metronidazole,gentamicin.The above treatment got a good therapeutic effect.Conclusion Pyometra has atypical symptoms with difficult diagnosis,and develops gradually.Gynecological ultrasound examination has great clinical significance.Full dilatation of cervix,discharging purulent material are the key to the success of conservation treatment and can achieve good results.Combination of endometrial cancer or other malignant tumor patients should take surgery as soon as possible,according to the tolerance ability.

With the coming era of targeted therapy,novel criteria such as the modified response evalu-ation criteria in solid tumors (RECIST),positron emission tomography response criteria in solid tumors (PETRCIST),Choi criteria and immune-related response criteria have been proposed as standardized methods to assess therapeutic response.Biomarkers and circulating tumor cells may be considered suitable for the evalu-ation of response.These criteria may be useful for the evaluation of therapeutic response to tumors.

Cancers evolution is a process of clonal selection,cell competition and clonal expansion. Cancers evolution includes cancer memory,heterogeneity,resistance,transformation and adaption et al.This evolution enables cancer cells to adapt to any hostile environment and to survive.An understanding of cancers evolution will provide a theoretical guidance for the implementation of the precision therapy.