[Objective] To explore the influence of nursing intervention in reducing cardiovascular risk factors in elderly patients with impaired glucose tolerance.[Methods] From May 2009 to June 2011,216 cases of elderly patients in the clinic of our hospital with impaired glucose tolerance were randomly divided into the intervention group and the control group with 108 cases in each.The control group adopted traditional routine care,and the intervention group received nursing intervention.The duration of followup and intervention was six months.The collected data included basic situation,and tested blood pressure,blood sugar,total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDLC)and low density lipoprotein cholesterol(LDL-C)before and after follow-up.[Results] For both two groups of patients,blood sugar levels were decreased,the decreased level in the intervention group was higher than that of the control group.[Conclusions] Nursing intervention for the elderly patients with impaired glucose tolerance plays a significant role in reducing cardiovascular risk factors and improving IGT prognosis.

The similar mechanism of human cancer and aging means that cancer is the natural result of aging.Mitochondrial replacement, genome editing, telomere synthesis and immune editing can induce cancer cell senescence and resist human aging, which may breach a limit to human lifespan.

Cerebral palsy, a non-progressive central dyskinesis caused by a variety of reasons. is one of the major diseases resulting in serious paralysis of children nervous system. At present there is no special treatment. and most are supporting and symptomatic treatments. In recent years, with development of recombinant DNA technology and cell biology. transgenic cell lines and cell line transplantation have become new focus of study in brain transplant. Currently the experimental studies on cell transplantation, especially stem cells. in the treatment of children cerebral palsy mainly refer to newborn animals with hypoxic-ischemic brain injury at acute phase. and have made some progresses. Studies have demonstrated that stem cells can survive longest for eight months after transplanted into the brain. and can migrate to the damage a/ca and differentiate into different phenotypes of nerve cells to improve partly neuroethology disorder. However. that transplanted stem cells differentiate into minimal target neurons may be ode of main reasons that cannot achieve ideal effects.

Breast cancer is a group of heterogeneous diseases.Molecular portraits provide a new insight for personalized cancer management in breast cancer.According to the molecular pathology,molecular biology and system biology,breast cancer goes through different typing methods,including four subclasses,geneexpression signature and integrated genomic classification.These major subtypes of breast cancer may provide guidance for precise therapeutics.

Rational microenvironment contributes actively to cancer development through multiple mechanisms including triggering genomics instability,providing shield,promoting immune escape,inducing differentiation and permissive nich.Tumorigenesis reversely promotes the form of tumor microenvironment composed of hypoxia,decreasing pH,angiogenesis and nutrition deficiency.Tumor microenvironment not only is the reasons but also results in cancer development and progression.A better understanding of how the tumor environment affects cancer progression would provide the new strategy for cancer therapy.

As semi-autonomous organelles,mitochondria are easily damaged by various factors.Mitochondrial dysfunction such as abnormal oxidative phosphorylation,metabolism alterations,apoptosis prevention,damaged mitophagy,immune escape and deregulated signaling pathway have been hypothesized to be involved in tumorigenesis.Modulated mitochondria may prevent the occurrence of tumors.

Objective To analyze the clinical features and results of array-comparative genomic hybridization (array CGH, aCGH) in a Chinese girl with Phelan-McDermid syndrome. Methods The clinical symptoms of a child with Phelan-Mc-Dermid syndrome were retrospectively analyzed. Routine G-banding was performed to analyze the karyotype, and the aCGH was used to analyze subchromosomal abnormalities. Results The routine karyotype analysis showed a normal female karyotype without abnomalities in chromosome number and structure. aCGH analysis finely mapped the deletion of Chr22q13.2-qter. Phel-an-McDermid syndrome was diagnosed for this case. Conclusions Phelan-McDermid syndrome can be diagnosed by the typi-cal and detailed clinical features in combination with the laboratory examinations of subchromosomal abnormalities. aCGH is one of the most valuable methods to analyze subchromosomal abnormalities and to diagnose Phelan-McDermid syndrome.

In patients with initially diagnosed unresectable cancers,resection of cancer sometimes becomes possible by systemic chemotherapy,and this model of chemotherapy is defined as conversion chemo-therapy. Conversion chemotherapy can improve objective response rate and resection rate,and it has shown an important value in metastatic colorectal cancer,advanced gastric cancer and unresectable hepatocellular carci-noma.

Maintenance therapy is an important strategy for cancer treatment,which mainly include continuation maintenance therapy and switch maintenance therapy,with a classical model of metronomic chemo-therapy.Maintenance therapy can be an effective treatment option for patients with non-small cell lung cancer, breast cancer,colorectal cancer and ovarian cancer.

Metronomic chemotherapy involves antiangiogenic processes that help host to fight against cancer by using continuous low dose drugs.Metronomic chemotherapy can be an effective treatment option for patients with head and neck carcinoma,breast cancer,gastrointestinal cancer,ovarian and prostate cancer. Metronomic chemotherapy also involves multiple mechanisms that include antiangiogenesis,immune stimulation and direct tumor cell targeting effects.We need to carefully evaluate the clinical effects of combination chemo-therapies that incorporate the other treatment schedules.