The protection of ginseno-side (GNS ) isolated from leaves and stems on cultured cell from virus were observed. The results showed that GNS, especially the Rb1 monomer could suppress replication of virus such as HSV -Ⅰ , HSV-Ⅱ ,ADV- Ⅲ and VSV, and protect the cultured cells from virus infec-tion. A cream containing GNS was used in the treatment of herpes lebialis infected by HSV- I and 27 of 31 (87. 1%) cases were cured.