Epilepsy is one of the five major neuropsychiatric diseases on which the World Health Organization focuses. New treatment methods are emerging, such as neuromodulation and radiofrequency ablation to remove lesions and precise treatment for gene mutation. However, antiepileptic drug therapy is still the first choice mostly. Since potassium bromide was applicated in epilepsy in 1857, which opened the prelude to the development of modern antiepileptic drugs, more than 20 kinds of antiepileptic drugs have been used in clinical practice. This article reviews the present status and future development of antiepileptic drugs at home and abroad.

On the basis of motor status of the frontalis musecle and the mouth corner 4 to 20 days after the onset, the degree and prognosis of facial paralysis of 218 cases were evaluated for 1～3 years. 44 cases belonged to neurapraxic type. In this type,visible motor recovery of frontalis and mouth corner was observed in 15 to 29 days after onset. Mild paralysis type (93 cases), in whom visible motor power of mouth corner appeared following the motor recovery of frontalis 14～20 days after onset, showed a total recovery in 24 to 40 days (84%). In moderate paralysis type, slight or absent visible motor recovery of frontalis was observed. Visible frontalis and mouth corner motor power appeared 20 days to 2 months after onset, with normal frontalis recovery in 42 cases.In 3 cases frontalis motor power recovered for 25% to 50%, and in 45 cases (67%) residual symptoms and complications were observed. Severe paralysis type consisted of 75% of patients, 36 patients, in whom the frontalis did not completely recover and 92% had residual symptoms and complications.Therefore, according to motor status of the frontalis and mouth corner, facial paralysis could be classified in predicting the prognosis.

ObjectiveTo observe the effect of low frequency current hydroelectric bath therapy modulated by medium frequency on sequela of sprain of ankle. Methods46 patients with sequela of sprain of ankle were treated with ZM C intellectual faculties intermediate frequency therapeutics instrument. Medium frequency was modulated with full square wave. The frequency of carrying wave was 4KHz. The frequency of modulated wave was 100Hz. The depth of modulation was 80%. The water temperature was 40℃.ResultsAfter treatment, all patients got satisfactory effect and shorter treating course without adverse reactions appearing. Conclusions The low frequency current hydroelectric bath therapy modulated by medium frequency is a simple, safe and better treating method for sequela of sprain of ankle.

Objective To compare the relativity between Tp-Te interval,Tp-Te /QT ratio with heart rate(HR)and explore their clinical significance retrospectively.Methods 200 normal individuals' ECG were randomly selected and the Tp-Te interval and Tp-Te/QT ratio were measured in precordial lead V6 retrospectively.The relativity between Tp-Te interval and Heart Rate,Tp-Te/QT ratio and Heart Rate were calculated retrospectively.Results The Tp-Te interval was about(83.17?12.64)ms in precordial lead V6 of normal individuals.The Tp-Te interval decreased linearly with the increase in HR with the range of Tp-Te interval being 56 to 114 milliseconds(Pearson's correlation coefficient r was-0.239,P=0.007 0.01).Conclusion There is an inverse correlation between Tp-Te interva and HR while no correlation between Tp-Te/QT ratio and HR.

Objective To investigate Tpeak - Tend interval and Tpeak - Tend/Q - T interval ratio in healthy people. Methods Q - T interval and Q - Tpeak interval (time interval from QRS - wave starting to T - wave peak) were measured on electrocardiogram in 100 healthy people, rectrospectively. Then , Tpeak - Tend was calculated by Q - T interval substrating Q - T peak, and T peak - Tend /Q -T interval ratio was calculated. Results T peak - T end /Q - T ratio and T peak - T end interval were greatest in lead V2 (0.24?0.04, 93.20?16.07)(ms) and smallest in lead avL (0.16?0.03 ,58.06?13.70) (ms). Tpeak - Tend interval in Ⅱ,Ⅲ,avR, V2～V6 were significantly greater in male than those in female. Tpeak - Tend /Q - T ratio in Ⅱ, Ⅲ, avR, avF, V2～V6 were significantly greater in male than those in female. Total 95% confidence interval of Tpeak - Tend interval and Tpeak - Tend /Q - T ratio in lead V2 were (90.01 , 96.39) (ms) and (0.23 , 0.25) /respectively. 95% confidence interval of Tpeak - Tend interval of Male and female subjects in lead V2 were (93.67,103.07) (ms) and (85.13,93.46) (ms) , respectively. 95% confidence interval of Tpeak -Tend interval of Male and female subjects in lead V2 were(0.24 ,0.26) and (0.21 ,0.24) , respectively. Conclusion Our study provides values of T peak -T end interval and T peak - T end/Q - T ratio in healthy people.

OBJECTIVE:To provide identification reference for the clinical use of Cinnabaris. METHODS:TCM micro-macro-scopical identification method and microscopic identification method were used. RESULTS:The micro-macroscopical characteristics were obtained:irregular granule or sheet block,different forms,wide bright red,opuque translucent with some luster; some sam-ples showed irregular lump with big shape,red scale on surface,dulling or gray-black. The were microscopic characteristics ob-tained:different forms of irregular granule,some sheet block,wide bright red,with some luster,occasionally with yellow gran-ules. CONCLUSIONS:The method for micro-macroscopical identification and microscopic identification of Cinnabaris is simple and convenient,and it can be used for the rapid verification of Cinnabaris.

Objective To explore the expression of aquaporin (AQP)-4 in white matter of spinal cord after spinal cord contusion (SCC). Methods 88 adult Sprague-Dawley rats were assigned randomly to sham operation group and SCC group. The model was established by Al-len's method. BBB sore was used to assess the motor function of rats. The relative expression of AQP-4 mRNA was determined by Q-PCR technique. The localization of AQP-4 was observed by immunohistochemistry. Results BBB score showed motor dysfunction in SCC group, and it increased 7 and 14 days after SCC (t>5.061, P<0.001). The level of AQP-4 mRNA decreased on the 1st and 3rd days (t>50.44, P<0.001), and increased on the 5th day (t=-3.968, P=0.001), and lasted until the 28th day (t=-4.227, P=0.001) compared with that on the 3rd day. The immunohistochemistry showed AQP-4 was located on the process of glial cell and vascular endothelial cells in white matter of spi-nal cord. Conclusion AQP-4 may play various roles at different stages in SCC.

Objective To assess cerebrovascular reserve capacity in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods One hundred and fourteen patients with OSAHS and 43 normal persons were enrolled in this study.The patients were divided into mild,moderate,severe according to apnea hypopnea index (AHI) and LSaO2 (lowest arterial oxygen saturation).All the patients and normal persons were routinely examined using transcranial Doppler (TCD) and end-tidal carbon dioxide partial pressure(ETCO2) to evaluate cerebrovascular reserve.Hypercapnia was induced by inhaling the CO2 which produced by the patients themselves,and hypocapnia was elicited by voluntary hyperventilation.Results CVR in the severe and moderate OSAHS were significantly lower than that in the control group [ (1.80 ± 1.34) ％/mm Hg and (1.43 ±1.05)％/mm Hg vs (2.93 ±0.93)％/mm Hg,P ＜0.05] when patients in the condition of hypocapnia.And there was no significant difference on CRV between the mild OSAHS group and control group [ (2.53 ±1.83 ) ％/mm Hg vs ( 2.93 ± 0.93 ) ％/mm Hg,P ＞ 0.05 ].When patients in the condition of Hypercapnia,CRV in the severe and moderate OSAHS were also significantly lower than that in the control group [ ( 1.83 ±1.32) ％/mm Hg and (1.08 ± 1.00)％/mm Hg vs (3.32 ± 1.53)％/mm Hg,P ＜ 0.05),AHI was negatively correlated with the cerebrovascular reserve at the condition of hypercapnia and hypocapnia (r=-0.665,-0.721; P ＜ 0.05 ).Conclusion Inhaling CO2 is a effective method for assessing CVR.Cerebrovascular reserve capacity is associated with AHI.Reduced CVR causes hemodynamics change being severe hypoxia in the moderate and severe OSAHS.

Objective To investigate the effects of pulsed magnetic fields of different intensity on carotid restenosis (CRS), post carotid endarterectomy (CEA) and the expression of matrix metalloproteinase-2 (MMP-2)in vascular smooth muscle cells (VSMC). Methods An animal model of carotid altherosclerosis was established in 50 New Zealand rabbits by using air-drying lesions combined with high fat feed. After two months, the rabbits were treated with bilateral CEA, and then divided randomly into 3 groups. Two of the groups were treated with ei-ther 0.6 or 1.0 T pulsed magnetic fields, while the third group served as an untreated blank control. Changes in the pathology of the tunica intima were observed 1, 2 and 3 months after the CEA using morphologic analysis, and the expression of MMP-2 in the VSMC was determined using immunohistochemistry. Results The histological a-nalysis showed that the total luminal area, plaque area, the maximum plaque thickness and the proportion of siena-sis in the treated groups were all significandy lower, on average, than in the control group. At all three time points the average improvements in the 1.0 T group were significantly greater than in the 0.6 T group. The average ex-pression of MMP-2 in the treated groups was significantly lower than in the control group, especially in the 1.0 T group. Conclusions Pulsed magnetic field therapy positively influences CRS and the expression of MMP-2 in VSMC. Reduced MMP-2 expression might be one of the mechanisms through which pulsed magnetic fields prevent or lessen carotid restenosis post CEA.

BACKGROUND:Animal modeling has reported that psychological stress can lead temporomandibular joint disease in rats, and there wil be pathological changes.
OBJECTIVE:To observe the effects of psychological stress on the expressions of vascular endothelial growth factor and transforming growth factor-β1 in rat temporomandibular joint condylar chondrocytes
METHODS:Forty-eight adult male Wistar rats were randomly divided into the experimental group and the control group, 6 rats in the experimental group and 12 rats in the control group. Thirty-six Wister male adult rats in the experimental group were subjected to the fol owing stimulating factors, such as electroshock, keeping stil ness, climate change and food tempting in order to make them under psychological stress. Then, the experimental group rats were executed at 3 weeks after stimulation (3 weeks stimulation group), 6 weeks after stimulation (6 weeks stimulation group) and 6 weeks normal feeding after 6 week stimulation (recovery group), 12 rats were sacrificed at each time point. The 12 rats in the control group were executed at the same time as the last experimental group. The temporomandibular joint specimens were taken to produce slices.
RESULTS AND CONCLUSION:The vascular endothelial growth factor-positive rate of recovery group was significantly larger than that of the 3 weeks stimulation group and the control group (P<0.05);transforming growth factor-β1 positive rate in the 6 weeks stimulation group was significantly greater than that in the control group (P<0.05). It indicated that vascular endothelial growth factor was related with the new blood capil aries repairing tissue, and transforming growth factor-β1 might play a role that stimulates bone resorption in psychological stress.