OBJECTIVE:To observe the clinical efficacy and safety of leflunomide combined with prednisone in the treatment of polymyositis. METHODS:Totally 98 polymyositis patients in our hospital were divided into observation group and control group by random number table,49 cases in each group. Control group received Prednisone tablet with initial dose of 60-100 mg/d,tid, then gradually reduced to maintaining dose of 10 mg/d,tid,based on patients'improvement of creatine kinase(CK)and clinical symptoms. Observation group was additionally given Leflunomide tablet 10 mg,bid,based on the control group. They all treated for 120 d. Clinical efficacy,muscle strength evaluation,muscle enzymes [including CK,lactate dehydrogenase(LDH),aspartate aminotransferase(AST),creatine phosphokinase(CPK),alanine aminotransferase(ALT)] and serum inflammatory factors(includ-ing IL-2,IL-8,IL-12,TNF-α,hs-CRP)before and after treatment in 2 groups were observed,the incidence of adverse reactions in 2 groups was recorded. RESULTS:After treatment,the total effective rate(87.8% vs. 75.5%)and muscle strength achieving grade 3(81.6% vs. 55.1%)in observation group were significantly higher than control group,and the total adverse reaction rate (12.2% vs. 22.4%)was lower than control,with statistically significances(P<0.05). After treatment,the muscle enzymes and se-rum inflammatory factor levels in groups were significantly lower than before,and observation group was lower than control group,with statistically significances(P<0.05). CONCLUSIONS:Leflunomide combined with prednisone shows good efficacy in the treatment of polymyositis,it can significantly improve the muscle strength,muscle enzymes and serum inflammatory factor lev-els,and dose not increase the incidence of adverse reactions,with good safety.

Objective To investigate the risk factors of cesarean section operation incision infection ,so as to provide refer‐ence for preventing and controlling cesarean section operation incision infection effectively .Methods A total of 29 cases were se‐lected who hospitalized in our hospital during December 2011 and December 2012 and whose incision of cesarean operation was in‐fected as the observation group .They were retrospectively analyzed .Then another 29 cases were chosen whose incision of cesarean operation was not infected as the control group .The clinical data in two groups were compared and the risk of infected incision were investigated .Results The incision infection occurred in 29 of 589 cases undergoing cesarean section with the infection rate 4 .9% . Univariate analysis showed that ,the maternal BMI in observation group was (25 .9 ± 1 .1)kg /m2 ,uterine scar for 6 cases ,emergency operation for 18 cases ,operation time was(1 .2 ± 0 .6) h ,the hospitalization time was (7 .1 ± 2 .3) d ,6 cases with underlying disease , premature rupture of membranes for 12 cases ,the vagina and anus diagnosis number was(3 .3 ± 0 .6) times ,the comparison with the control group ,the difference was statistically significant (P< 0 .05) .Multivariate Logistic regression analysis showed ,BMI (OR =2 .802) ,operation time (OR = 5 .813) ,with basic diseases (OR = 6 .182) ,premature rupture of membranes (OR = 11 .219) were risk factors for cesarean section operation incision infection .Conclusion There are many factors that can influence the surgical incision infections .It is necessary for the high‐risk population to take effective measures to prevent surgical incision infections .

Taking the 8-year management practice of Sanjiu Brain Hospital of Guangdong since its founding as a case, the paper gives an account of how the hospital managed to grow by leaps and bounds. The steps taken include: guiding decision-making with innovations in thought and blazing new trails in such aspects as growth strategies, leadership structure, system of operation, quality control, nursing management, service skills, marketing management, hospital culture, and logistics management. The paper argues that innovation is the soul and driving force of hospital management and reform and that daring to and knowing how to make innovations are indispensable to enhancing the core competitiveness of the hospital and promoting its fast and sustainable growth.

Objective To explore the effect of interventional ward to the development of interventional radiology.Methods Investigation of the first class of the third grade hospitals in northeast region of China for the development status of interventional radiology in 2005 through questionnaires was undertaken.The hospitals were divided into two groups according to setting up interventional ward or not,together with comparative studies of number of doctors,sorts of interventional techniques and number of cases.Results Altogether 52 3rd grade,1st class hospitals have established interventional therapy,including with ward of 29(55.8%)and no ward of 23(44.2%);furthermore the average numbers of doctors in the forementioned two kinds of hospitals were 4.8 ? 1.7 vs 2.8 ? 1.5(P

Clinical studies remain the corresponding risk, during the study period can sometimes cause pa-tients/subjects health damage directly or even life safety;also some at the end of the study after a certain period or in the offspring can reflect the long-term adverse effects. Clinical research project risk classification method is dis-cussed, according to the influencing factors of risk can be divided into two categories, their sexual and artificially, and from their sexual risk, the researchers risk, the sponsor problems and subjects of the four aspects of risk identi-fication and evaluation is discussed in detail. Based on this, advances the tactics of risk aversion: construction of clinical research and regulation of ethical management platform,To strengthen the external supervision of research project risk, The sponsor or researchers do their job, To strengthen the construction of institutional ethics committee ability, Give full play to the institutional ethics committee functions,Risk transfer and reduce the risk.

Objective To study the expression of cIAP and Caspase‐7 in endometrial adenocarcinoma tissue and its relation with prognosis .Methods Fifty‐five cases tissues of endometrial adenocarcinoma patients were detected by immunohistochemistry assay from the First Affiliated Hospital of Henan University of Science and Technology from 2009 to 2010 .Histological classifica‐tion ,pathological stage ,lymph node metastasis ,age and other parameters were collected ,the survival and overall survival of the tumor were followed up ,immunohistochemistry was used to observe the expression of cIAP and Caspase‐7 in paraffin sections of pathological specimens ,and the relationship between them and the parameters were analyzed .Results The expression level of cIAP and Caspase‐7 was related to the histological classification ,pathological stage and lymph node metastasis of endometrial carcinoma (P<0 .05) ,but it was not related with the age ,muscular layer infiltration(P>0 .05) .There was significant difference between the positive expression and the negative expression of cIAP and Caspase‐7(P<0 .05) .Conclusion The expression level of cIAP and Caspase‐7 in patients with endometrial carcinoma is correlated with tumor grade and overall survival ,or can be used as a prognostic indicator for endometrial cancer .

Objective To investigate the expression of tissue transglutaminase(tTG) and vascular endothelial growth factor(VEGF) in epithelial ovarian carcinoma and the relationship of invasion and metastance in ovarian carcinoma.Methods The expression of tTG and VEGF was detected in 55 malignant and 21 benign ovarian neoplasms by immunohistochemical SP method.The clinical significance of tTG and VEGF and their relationship were analyzed.Results The expression rates of tTG and VEGF in malignant epithelial ovarian tumors were significantly higher than in benign epithelial ovarian tumors(tTG:92.7％ vs.38.1％,x2 =32.620,P ＜0.01 ;VEGF:90.9％ vs.47.6％,x2 =19.570,P ＜0.01).In ovarian cancer,the expression of tTG in tumor cells and stromal cells was significantly related to clinical phases and the presence of ascites.The expression of VEGF in tumor cells had a significant revelance to clinical phases,pathological grades and ascites.The expression of tTG in ovarian cancer cells was positively correlated with VEGF(r =0.8856,x2 =43.14,P ＜0.01).Conclusion Tissue transglutaminase and VEGF were detected not only in tumor cells,but also instromal cells.High expression of tTG and VEGF may play an importaant role in the pathogenesis of ovarian cancer and their synergistic effect may act as an important factor in promoting the invasion and metastasis of this cancer.

ObjectiveTo investigate the expression of EMMPRIN and MMP-9 in epithelial ovarian carcinoma and the relationship of invasion and metastasis in ovarian carcinoma.MethodsThe expression of EMMPRIN and MMP-9 was detected in 55 malignant and 21 benign ovarian neoplasms by immunohistochemical Sp method.ResultsThe expression rate of EMMPRIN and MMP-9 in malignant, benign epithelial ovarian tumors was 89.1％, 14.3％ and 96.4％, 23.8％, respectively.There were significance different between malignant tumors and benign tumors.In ovarian cancer, the expression of EMMPRIN in tumor cells had a significant relevance to clinical phases and pathology types, while the expression of EMMPRIN in stromal ceils was associated with clinical phases, pathology types and pathological grades.The expression of MMP-9 in tumor cells had a significant relevance to clinical phases and pathology types while the expression of MMP-9 in stromal cells was associated with clinical phases, pathology types and ascites.ConclusionsEMMPRIN and MMP-9 were detected not only in tumor cells, but also in stoma cells.High expression of EMMPRIN and MMP-9 may play an important role in the pathogenesis of ovarian cancer, and their synergistic effect may act as an important factor in promoting the invasion and metastasis of ovarian cancer.

Objective To evaluate the effi ciency of thrombectomy of iliac-femoral venous thrombosis (I-FVT) via transjugular approach. Methods Seven patients wit h I-FVT were treated with implantation of inferior vena caval filter, balloon- di rected drag, and catheter-directed suction. Some patients were treated with PTA and stent. Meanwhile, strict anti-coagulation was necessary. Results Thrombectom y via transjugular was successful in all 7 patients. The iliac- femoral veins w e re patent after the operation and swollen symptom of lower limb disappeared. The re was swollen of the lower limb in 1 patient after treatment. Symptom disappear ed after PTA or stent treatment again. There were no serious complications. Foll ow-up study showed no pulmonary embolization or recrudescence in all 7 patients . Conclusion Thrombectomy via transjugular approach is a safe an d effective method for the treatment of I-FVT.

Objective To establish the UPLC fingerprint of Shuanghuanglian powder-injection. Methods Acquity UPLCTM BEH C18 Column (2.1 mm × 50 mm, 1.7 μm) was established;mobile phase was acetonitrile and 0.1%formic acid with gradient elution;the flow rate was 0.3 mL/min;the column temperature was 40 ℃. Characteristic spectrum cluster of 13 batches of Shuanghuanglian powder-injection were analyzed, and Chinese Medicine Chromatographic Fingerprint Evaluation System (2004 A) was used to evaluate their quality. Results UPLC fingerprint common mode of 13 batches of Shuanghuanglian powder-injection was established. There were total 16 common spectrum peaks in the reference for comparison, and three main peaks were identified with better separation. The 13 batchs had good consistency, and the process was stable. Conclusion The method is rapid, efficient and can be used for full control of the quality of Shuanghuanglian powder-injection.