Objective To analyze the variations and influencing factors of hospitalization expenditure of cervical cancer patients among urban employees in Beijing from 2006 to 2010,and to provide evidences for developing reasonable measures of medical expenses control.Methods Based on the hospitalization expenditure data of 1146 cervical cancer cases,the paper probed into the changes of hospitalization age and hospitalization expenditure,and the influencing factors of hospitalization expenditure by means of descriptive analysis and multiple stepwise regression.Results The last 5 years witnessed no significant change in the first hospitalization age of cervical cancer patients,rise of hospitalization age,gradual rise of the hospitalization expenditure per time along with their age groups,as well as a rising trend of the average hospitalization expenses,average drug cost and proportion of average drug cost year by year.Results of the multiple stepwise linear regression showed that days of stay,proportion of drug cost and surgery or not as important influencing factors for hospitalization expenditure.Conclusion Hospitalization expenditure of cervical cancer keeps growing.Against this background,reasonable shortening of the days of stay,reasonable setup of an appropriate proportion of out-of-pocket payment,and reduction of the proportion of drug costs become effective means to reduce hospitalization expenditure.

Targeted agents for advanced colorectal cancer mainly include inhibitors of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR).Studies show that bevacizumab and cetuximab can improve the prognosis of advanced colorectal cancer patients,but there is slight difference in the choice of chemotherapy regimens when combined with them.Bevacizumab and cetuximab can improve the overall survival of K-ras wild-type colorectal cancer patients similarly.The emergence of new targeted drugs such as aflibercept,regorafenib provides more choices for the targeted therapy of advanced colorectal cancer patients.

In order to create a high-quality online course of Medical Ethics, this research group retrieved 16 domestic MOOC platforms in order to understand the current status of the online course construction of Medical Ethicsin Chinese universities before the outbreak of epidemic. The survey results showed that 12 teaching teams from 11 universities have built the Medical EthicsMOOC on 8 network platforms. These 12 online courses have not only played an important role in the teaching of this course during the epidemic, but also would provide valuable experience for leading Chinese universities in the online learning and teaching reform of Medical Ethics. Finally, there are three suggestions for the current problems about online teaching of medical education: firstly, increase network speed and reduce network traffic charges; secondly, utilize virtual space to make up for the lack of real space; thirdly, set up cross-professional, interdisciplinary and trans-school's compound golden courses teaching teams.

Objective To explore the relationships between the serum and urinary levels of procollagen Ⅲ and renal injury at the early stage of hypertension in sponantously hypertensive rats. Methods 16 sponantously hypertensive rats (SHR) were divided into treated group (losartan 30mg?kg -1?d -1) and untreated group, each group containing 8 animals, and 8 Wistar-kyoto rats served as normotensive control group(WKY). The serum and urinary levels of procollagen Ⅲ and ? 2-microglobin, and urinary microalbumin level were measured by radioimmunoassay 16 weeks after treatment. Results Blood pressure, serum ? 2-microglobin level, and the urinary levels of procollgen Ⅲ, ? 2-microglobin and microalbumin in SHR were significantly higher than those in wistar-kyoto rats. Losartan could decease the levels of the indices above in SHR. Serum procollagen Ⅲ level had not significant difference among the three groups of rats, and was not correlated with urinary procollagen Ⅲ level. There were positive correlation between serum and urinary ? 2-microglobin levels, and urinary procollgen Ⅲ level was positively retated to urinary ? 2-microglobin, urinary microalbumin and systalic pressure. Conclusion The levels of urinary procollgen Ⅲ,? 2-microglobin and microalbumin could reflect the lesion of glomerulus and tubulointerstitum at the early stage of essential hypertension in SHR.

It's a new financial management system that our country implemented the management of separating the income and expenditure in the community health services.Beijing is one of the former pilot cities which carried on the management of separating the income and expenditure.To know the effectiveness of the implementations and its influence to the health services,this article analyses the status of community health services,the financial investment and the performance results in Beijing.Considering the above,this paper also provides policy recommendations on the development of health services in Beijing to improve the new urban medical service system which based on the community health services.

Cyclic voltammetry shows that, in a supporting ele ctrolyte of NaOH,riboflavine tetrabutyrate（RT）has a pair of cathodic and anodi c peaks at Hg electrode. The peak potentials Epc=Epa=-0.64　 V（vs.Ag/Agcl）.　The adsorptive characteristics of RT are explored in detai ls with various methods.　The adsorbed species is most probably neutral molecule of RT.The saturated adsorption amount of RT at Hg electrode is 5.42×10-11 　mol/cm2 and every RT molecule occupied 3.06　nm2. On the surface of HMDE ，the adsorption of RT obeys Frumkin dasorption isotherm. The adsorptive coeffic ient β，the attractive factor γ are 4.60×105，1.10 and the adsorption free energy ΔG, is　－32.30　kJ/mol, respectively. The electrode proc ess kinetic behavior has also been studied by using cyclic voltammetry. Under th e experimental conditions the rate constants for electron transfer are determine d. The values of ks are in good agreement with literature′s results.

Objective: To investigate the alteration of red cell deformability (RCD) and adenosine triphosphatase (ATPase) activity of cell membrane in essential hypertensive (EH) patients and essential hypertension patients complicated with cerebral infarction (HCI). Methods: Twenty healthy individuals, 30 EH patients and 30 HCI patients were selected as subjects. The erythrocyte deformability indexes (DI)、 Na+, K+-ATPase and Ca2+ATPase activities were examined. Results: (1) EH patients had significantly higher DI, lower ATPase activity as compared to healthy individuals. There were significantly negative correlation between DI and ATPase activity, and a significantly positive correalation between DI and diastolic blood pressure in EH patients; (2) There was significantly higher DI, lower ATPase activity in HCI patients than those in EH patients. There was significantly negative correlation between DIand ATPase activity in HCI patients. Conclusion: (1) RCD decreases in EH patients, and RCD is correlated to the decreased ATPase of cell membrane and elevated blood pressure; (2) The decreased RCD level may be related to the occurrence of HCI.

Objective To investigate the relations between BNP and cTnI leveh in patients with CHF and cardiac function.Methods 75 patients with CHF were selected as observation group and another 30 healthy people were selected as control group.BNP and cTnI levels were detected by electrochemiluminescence immunoassay and the data were analyzed.Results BNP and cTnI of observation group were significantly higher than control group,the difference was statistically significant(t=3.897,4.127,all P＜0.05);comparison of BNP and cTnI levels in different classification of cardiac function of observation group had significant difference(F=4.765,5.876,allP＜0.05);Linear corrlation analysis showed that:BNP and cTnI both positively correlated to classification of cardiac function(r=0.853,0.647,all P＜0.05),BNP and cTnI increased significantly with the increase of cardiac function classification.Conclusion BNP and cTnI increased significantly in patients with CHF and closely related with cardiac function.they were ideal index to evaluate the CHF severity and had a good clinical value to judge the status and function of heart in patients with CHF.

Background:Prostaglandin E2(PGE2 )could promote the proliferation of tumor cells,microRNA-21(miR-21)could inhibit the proliferation of tumor cells,but its signal pathway is still unclear. Aims:To investigate the mechanism of PGE2 on promoting proliferation of gastric cancer cells potentially mediated by miR-21. Methods:Gastric cancer AGS cells were cultured and divided into control group,PGE2 group,anti-miR-21 group and PGE2 + anti-miR-21 group. Cell proliferation was determined by WST-1 chromatometry. Cell apoptosis rate was detected by flow cytometry. The expression of miR-21 mRNA was detected by RT-PCR. After AGS cells were intervened by Akt specific inhibitor perifosine,cell proliferation was assessed,and expression of PTEN/ Akt protein was detected by Western blotting. Results:Compared with control group, survival rate of AGS cells was significantly increased(P < 0. 05),apoptosis rate was significantly decreased(P < 0. 05), and expression of miR-21 mRNA was significantly increased in PGE2 group(P <0. 05). Compared with PGE2 group, survival rate of AGS cells was significantly decreased(P < 0. 05),apoptosis rate was significantly increased(P < 0. 05), and expression of miR-21 mRNA was significantly decreased in anti-miR-21 group and PGE2 + anti-miR-21 group(P <0. 05). After intervention with perifosine,survival rate of AGS cells was significantly decreased(P < 0. 05),apoptosis rate was significantly increased(P < 0. 05),expression of PTEN protein was significantly increased,and expression of p-Akt protein was significantly decreased. Conclusions:MiR-21 mediates the promoting of proliferation of gastric cancer cells by PGE2 through PTEN/ Akt pathway,which might become a new target for the prevention and treatment of gastric cancer.