BACKGROUND:Since percutaneous injection of bone cement vertebroplasty has been successful y used in treatment of spine fracture, percutaneous vertebroplasty is trying to be utilized in the treatment of vertebral hemangiomas.
OBJECTIVE:To evaluate the safety and effectiveness of percutaneous injection of bone cement vertebroplasty in the treatment of symptomatic vertebral hemangiomas.
METHODS:Total y nine patients with symptomatic thoracic vertebral hemangioma patients, including two males and seven females, had back pain. Of them, two cases suffered from nerve root irritation. Percutaneous vertebroplasty with bone cement was used alone. Postoperative clinical and radiographic fol ow-up was conducted.
RESULTS AND CONCLUSION:The success rate was 100%, and no pulmonary embolism or nerve injury appeared. Postoperative imaging showed no leakage of spinal canal or foramen. At 24 hours after treatment, the symptoms had eased;nine cases were fol owed up for 3 to 36 months, showing that the original symptoms and signs disappeared or almost disappeared, no recurrence of vascular tumors. Results indicated that the percutaneous injection of bone cement vertebroplasty for the treatment of symptomatic vertebral hemangiomas is a safe and effective treatment;it can not only relieve symptoms, but also can increase the stability of the vertebral body, and prevent compression fracture and recurrence.

Esophageal squamous cell carcinoma (ESCC) accounts for more than 90% of the confirmed cases of esophageal cancer in Asia, and the degree of malignancy is high. There is a growing number of research on ESCC immunotherapy, particularly programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1). Among them, the most studied PD-1/PD-L1 inhibitors in ESCC are nivolumab, pembrolizumab, camrelizumab, toripalimab, tislelizumab, atozolizumab, SHR-1316 and durvalumab. Some of the clinical trials of these drugs are still in progress, and some have initially shown good results.

BACKGROUND:Bal oon kyphoplasty is a new technique of microtraumatic surgery of spine developed in recent years, and brings a new pathway for the treatment of osteoporotic vertebral fracture in the elderly.
OBJECTIVE:To investigate the therapeutic effect of percutaneous bal oon kyphoplasty on osteoporotic vertebral fracture, and to explore the main point of injecting bone cement.
METHODS:A total of 22 patients with osteoporotic vertebral fracture at the age of 60-78 years underwent percutaneous bal oon kyphoplasty under C-arm fluoroscopy. In accordance with the standards of WHO, antalgic effects were evaluated. The injection time, manner and dose of bone cement were analyzed.
RESULTS AND CONCLUSION:Al patients were fol owed up for 1-12 months. Postoperative pain was completely lessened in 15 patients, and partial y relieved in 7 cases, with an effective rate of 100%. Spinal mobility increased. No incision surgery was needed in al patients. No complications such as pulmonary embolism or nerve injury appeared. These results indicate that percutaneous bal oon kyphoplasty for treatment of osteoporotic vertebral fractures is minimal y invasive and simple, has less complication and effectively reconstructs vertebral body strength, and can better al eviate the pain, is an effective minimal y invasive spinal treatment technology. To strictly understand the main treatment point can obtain satisfactory clinical curative effects, including precise diagnosis of the disease, identification whether patient’s pain is induced by fractures, preoperative intraoperative exact localization of the affected vertebra, perfect puncturing technique, suitable postoperative treatment and nursing. It is also important to strictly master the time of injecting bone cement and the dose of bone cement. Bone cement injection was commonly done in drawing-wire stage. Too early injection easily induced leakage and toxic reaction. Too late injection affected the expansion of bone cement and therapeutic effects. The injection of bone cement should be finished under a perspective environment, which can effectively avoid bone cement leakage.

In order to create a high-quality online course of Medical Ethics, this research group retrieved 16 domestic MOOC platforms in order to understand the current status of the online course construction of Medical Ethicsin Chinese universities before the outbreak of epidemic. The survey results showed that 12 teaching teams from 11 universities have built the Medical EthicsMOOC on 8 network platforms. These 12 online courses have not only played an important role in the teaching of this course during the epidemic, but also would provide valuable experience for leading Chinese universities in the online learning and teaching reform of Medical Ethics. Finally, there are three suggestions for the current problems about online teaching of medical education: firstly, increase network speed and reduce network traffic charges; secondly, utilize virtual space to make up for the lack of real space; thirdly, set up cross-professional, interdisciplinary and trans-school's compound golden courses teaching teams.

Objective To explore the anticoagulation effect of low molecular weight heparin (LMWH) combination with warfarin at the early stage at the treatment of intracranial venous sinus thrombosis.Methods 80 cases of intracranial venous sinus thrombosis patients in people's hospital of Xinjiang Uygur autononous region from January 2010 to December 2014 were chosen to be analyzed retrospectively.37 cases in observation group were treated with low molecular heparin (LMWH) in combination with warfarin, and 43 cases in control group were treated with warfarin.The clinical curative effect between two groups was compared post-treatment.Results The effective rate in observation group was 91.89%, which was significantly higher than 67.44% in control group (P<0.05) .The recanalization rate of involved intracerebral venous in observation group was 89.19%, which was significantly higher than 67.29% in control group(P<0.05).After treatment, the prothrombin time (PT), thrombin time (TT) and activated partial thromboplastin time (APTT) were higher and fibrinogen (FBG) in both groups was lower than those pre-treatment(P<0.05).The PT and APTT was higher and FBG was lower in observation group than those in control group(P<0.05).Conclusion Low molecular weight heparin in combination with warfarin worked well than single warfarin in the treatment of intracranial venous sinus thrombosis.

OBJECTIVE:To observe clinical efficacy and safety of Chaihu shugan powder combined with clonazepam in the treatment of liver qi stagnation type anxiety. METHODS:96 patients with liver qi stagnation type anxiety were randomly divided in-to observation group and control group,with 48 cases in each group. Control group was given Clonazepam tablet with initial dose of 0.5 mg,increasing to 4.0 mg gradually,tid;observation group was additionally given Chaihu shugan powder 300 ml,bid,on the basis of control group. Both groups were treated for 6 weeks. Clinical efficacy of 2 groups were observed,and HAMA and SAS were observed before and after treatment;the incidence of ADR were compared between 2 groups. RESULTS:The total effective rate of observation group(97.92%)was significantly higher than that of control group(83.33%),with statistical significance(P<0.05). There was no statistical significance in HAMA and SAS between 2 groups before treatment(P>0.05);HAMA and SAS of 2 groups decreased significantly 1,3 and 6 weeks after treatment,and the observation group was lower than the control group, with statistical significance(P<0.05). There was no statistical significance in the incidence of ADR between 2 groups(P>0.05). CONCLUSIONS:Chaihu shugan powder combined with clonazepam is effective,improve patient anxiety and safe in the treatment of liver qi stagnation type anxiety.

Objective To study the impacts of medicine and pharmacy separation reform on medical insurance fund and medical care seeking behavior of such patients.Methods The insurance data of patients was collected from year 201 1 to year 2014 at the hospital of the author.The differences of hospitals' revenue from insurance,the use of insurance fund and medical care seeking behavior of patients,before and after the reform were analyzed.Results The results showed that the effect of medicine and pharmacy separation reform in achieving translation;the proportions of drug and per-patient drug expenses were reduced.However,the demand of insurance fund was increased,and the fund used in outpatients began to exceed that used in inpatients after the reform.Totally,the choices of outpatients on doctor's technical titles were influenced by the pricing,as more outpatients tended to choose the intermediate title doctors,and the proportion was increasing.The differences of the choices on the outpatient in superior departments were very small,while those in non-dominant departments were very big,the same as the total patients.Conclusion There are both advantages and disadvantages in impacts of the reform on medical insurance fund conducted in some hospital in Beijing.The advantages included that the hospitals'revenue was not decreased from insurance patients,the use of insurance on paying drugs were reduced by management of proper medication, and out-of-pocket burden of the insurance patients was reduced.Yet the disadvantages contained that because of cheaper drugs and favorable insurance policy on the reform,the outpatients preferred higher level hospitals to buy drugs only,and the reform might lead to the increase of the requirement of insurance fund.

OBJECTIVE To investigate and analyze the cause of the cross infection of Methicillin-resistant Staphylococcus aureus(MRSA) in ICU patients,and to apporach its preventive and control measures.METHODS Eiological inspection and sanitary monitoring have been done in ICU where there were two MRSA patients from June 6th,2008 to August 1st,2008.RESULTS MRSA has been detected on the hands of the ICU medical staff,on the bed-desks,on the switches of the vacuum extractor and gas supply unit on the wall,and in the NS for inhaling sputum.The separation rate were 37.5%,20.0%,54.5%,37.5%,87.5%.CONCLUSIONS ICU patients are prone to be infected with MRSA,which has a strong drug resistance and the infection is difficult to be treated.The cross infection can be prevented and controlled by rational administration,sterile operation and insulation.

Objective To evaluate the effect of furosemide on Cl -/HCO- 3 exchange of inner medullary collecting duct(IMCD) in rabbit kidney. Methods The effect of furosemide in different concentrations on the changes in Cl -/HCO- 3 exchange in mono-layer of IMCD cell in rabbit kidney was determined by fluorescent probe technique. Results Cl -/HCO- 3 exchange in IMCD cell could be inhibited by 4.3% by 15?mol/L furo semide solution, and 480?mol/L furosemide solution could inhibit the exchange by 97.4%. The Cl -/HCO- 3 exchange rates of the groups, in which the final concentrations of furosemide were equal to or higher than 30?mol/L, were significantly lower than that of the control group(P

Objective To explore the protective effects of extraction of Glycyrrhiza uralensis Fisch. (GC) on CCl4 induced acute hepatic injury in mice. Methods Acute hepatic injury model was made by CCl4. Fifty mice were divided into 5 groups (normal control group, CCl4 model group, bifendate group, low and high dose of GC group) and administrated for 7 days. The levels of ALT, AST, ALP, LPH, TP, ALB, GLB in serum and the activities of SOD, MDA in liver tissue were detected. Results The activities of ALT, AST and the level of MDA in GC group were significantly decreased, and the activity of SOD were significantly increased compared with the model group (P