ve To explore the health impacts of air pollution on children. Methods Based on monitoring data on outdoor air pollutants of SO2, NOx, TSP and CO, The local non-specific immune function [the activity of saliva lysozyme, the content of secretory immunoglobulin A (SIgA)]and the pulmonary ventilation function [vital ca-pacity (VC), forced vital capacity (FVC), forced expiratory volume in one second (FEV1), 25%, 50% and 75% forced expiratory volume in one second (V25, V50, V75) and maximum ventilatory volume (MVV)] were determined, and the questionaire was carried out among 656 school-age children aged 7~15 yrs in industrial area (polluted area)and 712 school-age children aged 7~15 yrs in relative clean area (control area). Results Significantly higher levels of SO2, NOx , TSP in outdoor air were found in polluted area compared with those in control area ( P

ObjectiveTo study the method decreasing muscle tensility of upper limb and improving the function of disabled limb and hand on the spastic period in children with hemiplegia.Methods32 children with hemiplegia were randomly divided into Wuida (16cases ) and Bobath group (16cases ). The evaluation was done 1 weeks before treatment, then Wuida and Bobath therapy was used to decrease muscle tensility and abnormal gesture. After spasticity untroubled, both groups had undergone suitable occupational therapy for three months.ResultsThe decrease of the spasticity and the function of disabled limb and hand in Wuida group were better than those in Bobath group.ConclusionsWuida therapy can decrease muscle tensility of upper limb on the spastic period in children with hemiplegia.

Objective To investigate the organic pollutants in the contaminated water irrigation area soil and to study the lipid peroxidation effect of the pollutants on mouse. Methods The organic pollutants of the polluted irrigation soil and control soil were extracted using the supersonic oscillator. The ingredients of the organic pollutants were measured by the GC-MS spectrum. The 40 sanitary Kunming mice were randomly divided into five groups: the dimethylsulfoxide control group,low dose group of control soil,high dose group of control soil,low dose group of polluted soil,high dose group of polluted soil. The administered doses of the low and high dose groups were 25.5 g dry soil/kg body weight per day by oral for two weeks. The activities of T-SOD,GSH-Px and the content of MDA in serum of mice were determined. Results Phenanthrene,yrene,diphenyl,fluorene,naphthalene,dimethyl-naphthalene,2,3,6-trimethyl-naphthalene,anthracene,dimethyl-anthracene,1,4-dimethyl-anthracene,fluoranthene,4-methyl-pyrene,dibenzothiophen,4-methyl-dibenzofuran,dibenzofuran,butylated-hydroxytoluene,dodecane,neopentyl-cyclohexane,trimethyl-heptane,1,2-dimethyl-cyclohexanimine,butethal were detected in the polluted irrigation soil and their levels were 14.3,2.1,1.3,1.1,0.8,1.3,0.4,2.9,7.2,2.3,9.1,0.2,0.4,1.4,1.7,0.37,0.9,0.11,0.02,0.02 and 0.13 mg/kg respectively in the polluted irrigation soil. Trimethyl-heptane,dimethyl-heptane and 1,2-dimethyl-cyclohexanimine were detected,and their levels were all 0.01 mg/kg in control soil. Compared with the solvent of dimethylsulfoxide group,the activities of T-SOD and GSH-Px of the high dose group of control soil and two dose groups of polluted soil all decreased,the differences were all significant(P0.05). Conclusion The soil has been contaminated with organic pollutants in the investigated area and the soil extract may produce a certain effect on lipid peroxidation in mice.

Objective To investigate the diagnosis and surgical treatment of peripheral solitary pulmonary nodule (SPN).Methods From January 2007 to October 2012,the clinical data of 69 cases of SPN treated were analyzed prospectively.And postoperative pathologic examination results as the gold standard to determine spiral CT enhanced check the accuracy and consistency test (Kappa test).Results Twenty-eight cases were diagnosed as malignant SPN by preoperative CT,25 cases were diagnosed as malignant SPN by postoperative pathology.The accuracy of CT judgment SPN benign and malignancy was 89.3％ (25/28),the Kappa value was 0.503.All patients were followed up for 6-12 (9.6 ± 1.4) months.There was no recurrence or enlargement.Conclusions Enhanced spiral CT scan is more economical and practical way for identifying benign and malignant SPN.Malignant SPN diagnosed by CT should be considered having surgery and auxiliary thoracoscopy combined with intraoperative rapid freezing to determine the surgical approach.

ObjectiveTo assess the quality of applications for the state funds for natural sciences and the research capabilities of researchers in medicine and other relevant fields in China so as to provide the State Fund Committee for Natural Sciences with scientific basis for systematically planning research funds for the medical field and improving the system of supervising funds for life sciences. MethodsAnalysis was conducted on project applications that were submitted to the Life Sciences Department from 1984 through 2001 and underwent quantitative peer review to explore trends of changes in project applications, the scores and the rate of fund-winning projects. ResultsBoth the quantity and quality of project applications in medicine and other relevant fields showed the trend of going up year by year whereas the rate of fund-winning projects presented an opposite trend. ConclusionThe State Fund Committee for Natural Sciences ought to broaden the scope of subsidization for medicine and other relevant fields and readjust existing funds for life sciences so as to shunt and alleviate the application pressure in medicine and other relevant fields.

The paper analyzes the current situation of domestic second-tier hospitals from such perspectives as the allocation of nursing human resources, professional titles, the time needed to complete nursing tasks, and the actual number of nurse hours. It puts forward suggestions on the appropriate size and work load of the nursing force in domestic second-tier hospitals in the hope of providing empirical basis for revising the size of the nursing force in such hospitals.

Leukotriene is a crucial inflammation medium in the process of asthma,involved in the inflammation and remodeling of airway.This article summarizes the origin,synthesis and biological activity of leukotriene in asthma.and discuss the implications of leukotriene receptor antagonists(Montelukast)for asthma in children.The randomized.double-blind and muhicenter clinical trials are needed to determine the efficacy of Montelukast in infants less than 2 years old with asthma.

OBJECTIVE:To determine the contents of Pb,Cd,Hg,As and Cu in Panax notoginseng,Angelica sinensis,Ligus-ticum chuanxiong,Fallopia multiflora and Rheum palmatum commercially available in Tangshan. METHODS:Microwave diges-tion-inductively coupled plasma mass spectrometry(ICP-MS)and single factor index and Nemerow comprehensive index were used to evaluate the heavy metal pollution in TCM powder samples;and the heavy metal limiting values in Green Trade Standards of Im-porting & Exporting Medical Plants & Prescriptions were used to evaluate the pollution of heavy metal samples. RESULTS:In the samples in 12 batches of 5 TCM powders,there were 2 heavy metal exceeded samples (P. notoginseng-3 and L. chuanxiong-2), the exceeded rate was 16.7%,exceeded indexes were Cd and Hg with the exceeded rates of 16.7% and 8.3%,respectively;heavy metals with Single factor index greater than 1 were Hg and Cd in P. notoginseng-3,and Cd in L. chuanxiong-2 with the composite indexes of 1.06 and 0.81,and pollution levels were slightly polluted and reaching warning level,respectively. CONCLUSIONS:Certain heavy metal pollution is found in TCM powder commercially available in Tangshan. Therefore,it is necessary to carry out more strictly control over the heavy metal content in Chinese herbal medicines.

Objective To analyze the results of the assessment of malaria elimination in 8 counties(districts)in Huai'an City,Jiangsu Province,so as to provide evidences for consolidating the achievement of malaria elimination. Methods The da-ta from the network reports of malaria epidemic situation,blood examinations of febrile patients,epidemiological questionnaires of malaria cases,investigation and disposal of epidemic focuses were collected and analyzed in Huai'an City from 2010 to 2016. The results of the assessment on the clinicians'ability of malaria diagnosis and treatment as well as the inspectors'skill of Plas-modium microscopic examinations were analyzed. In the natural village where the last local case of malaria was reported ,no less than 200 blood filter papers were made for gene detection of Plasmodium. Results From 2010 to 2016,308 malaria cases were reported in Huai'an City. Totally 323002 patients received blood detection of malaria,among which 272 ones were positive and the positive rate was 0.08％. The majority of the malaria cases were imported,except 19 and 3 local infection cases in 2010 and 2011,respectively. Except Qinghe District,a total of 1420 blood filter papers from the other 7 counties(districts)were detect-ed genetically,and the results were all negative. Six of the eight counties(districts)gained an average score of 20 points on the Plasmodium microscopic examination,and Jinhu County and Huai'an District got a minimum average score of 19.6 points. In ca-pacity assessment of malaria diagnosis and treatment,Hongze District gained the highest average score of 20 points,and Huai'an District got the lowest average score of 18.8 points. The malaria elimination assessment scores of the eight counties(districts) were all above 97 points. All the 8 counties(districts)in Huai'an City passed the malaria elimination assessment at county(dis-trict)level until 2016. Conclusions All the 8 counties(districts)in Huai'an City have passed the malaria elimination assess-ment with high scores. After the malaria elimination,the monitoring still should continue to consolidate the achievement.

Aim To investigate whether EGCG regu-lates ABCA1 expression by influencing the expression of miR-33 a to promote cholesterol efflux from macro-phages. Methods THP-1 macrophage-derived foam cells were established by co-incubated with oxLDL, and then treated with EGCG, and miR-33a expression was detected with Real-time PCR. THP-1 macrophage-derived foam cells were randomly divided into the fol-lowing groups: control group, 50 μmol · L-1 EGCG treatment group, 50 μmol · L-1 EGCG +80 nmol · L-1 miR-33a mimic treated group. Real-time PCR and Werstern blot was used to detect ABCA1 mRNA and protein expression, Oil Red O staining and high per-formance liquid chromatography were used to detect in-tracellular lipid content, and [3H] assay was used to determine cellular cholesterol efflux. Results EGCG could downregulate miRNA33 a expression in a dose-and time-dependent fashion within safe doses. EGCG significantly upregulated ABCA1 mRNA and protein expression, which could be inhibited after miRNA33 mimic transfected into cells, however. EGCG may re-duce lipid accumulation in THP-1 macrophage-derived foam cells, and this effect could also be weakened after miRNA33 mimic transfected. EGCG could reduce the accumulation of intracellular cholesterol,which was re-lated with EGCG promoting intracellular cholesterol ef-flux , and excess miRNA33 a transfected into cells could inhibit intracellular cholesterol efflux. Conclusion EGCG may upregulate ABCA1 expression by reducing miRNA33a generation, resulting in the promotion of cholesterol efflux from macrophages, which may be one of the molecular mechanisms of EGCG anti-atheroscle-rotic effect.