BACKGROUND: In the past, much attention was paid mainly to the body symptoms like focal neurological impairment in stroke, but the accompanied psychological symptoms were ignored easily.OBJECTIVE: To investigate the psychosocial factor in acute cerebrovascular disease and the mental state after the attack.DESIGN: Observational case-control study based on patients and healthy people.SETTING: A neurology department in a university hospital.PARTICIPANTS: Totally 55 patients with stroke hospitalized in Neurology Department of Hospital Affiliated to Medical College of Shaoxing Art and Science College and 35 healthy people taking physical examination from January 2001 to December 2003 in the hospital as controls.METHODS: Patients with acute cerebrovascular disease certified by CT/MR and people in control group took symptoms checklist-90(SCL-90) test within a month after attack.MAIN OUTCOME MEASURES: SCL-90 scores of the two groups.RESULTS: The condition of mental state in patients with acute cerebrovascular disease was worse than that in control group( P ＜ 0.01 ). There existed obvious physical and mental reaction. It was found in subsection analysis that the size and location of the focus had relationship with the degree of mental disorder after attack and it was easier to have mental disorder if the affection lied in left cerebral hemisphere.CONCLUSION: It is necessary to give psychological intervention in prevention and cure of acute cerebrovascular disease. Recognizing bad effect of stroke on psychoactivity may help to guide the treatment.

Objective To explore the related factors that lead to unqualified urine and stool routine test specimens, and put forward effective solutions. Methods Urine samples and stool samples of 500 cases were selected, and the unqualified urine and stool samples were analyzed thoroughly. Results The unqualified rate of routine urine test group was 5%, and the unqualified rate of fecal routine test group was 6.40%. Urine and stool test samples are not qualified a total of 57 cases, including 3 cases (5.26%) the lack of application, 5 cases (8.77%) test sample does not comply with the inspection application list information, 37 cases (64.91%), 3 cases of insufficient sample (5.26%) samples were contaminated, 4 cases (7.01%) for overtime, 5 cases (8.77%) were insufficient and inconsistent information. Conclusion The urine and stool often caused by the unqualified situation in clinical diagnosis, have a great relationship with the reason was largely related to nursing staff before collecting urine and stool specimens of patients with lack of guidance, and the acquisition is completed with the after is not strictly in accordance with the relevant standards carefully check samples, in order to effectively improve the current situation, the hospital needs to be more reasonable and scientific to collect urine and feces samples were developed on the basis of this process, by strengthening the training of nursing staff to the sample qualified to provide the important guarantee.

Objective To study the clinical efficacy of canalith reposition on benign paroxysmal positional vertigo(BPPV).Methods In the eighty patients with BPPV,the 45 cases with anterior semicircular canal were treated with Epley reposition method and the other 35 patients with the horizontal semicircular canal were treated with barbecue tumble method.The clinical efficacy was observed.Results The effective rate of the Epley reposition method for anterior semicircular canal patients was 95.5％ (43/45) and the effective rate of the barbecue tumble method for horizontal semicircular canal patients was 91.4％ (32/35).Conclusion The canalith reposition method treated with BPPV patients has high clinical efficacy,simple procedures,and no obvious adverse reactions.

Objective To compare the curative effects of laparoscopy and laparotomy on tubal pregnancy.Methods Hospital 104 cases of tubal pregnancy patients were randomly divided into the laparoscopic group,52 cases,52 cases of laparotomy group,the two groups were compared age,pregnancies,gestational mass size,blood HCG levels,surgery time,the amount of bleeding in surgery,tubal patency rate after one month.Results They had no significant difference between two groups on age,pregnancies,gestational mass size,blood HCG levels (P ＞ 0.05).And they had significant difference between two groups on surgery time,the amount of bleeding in surgery,tubal patency rate after one month [(40.33 ± 14.32) min vs.(85.67 ± 19.46) min,(5.67 ± 4.50) ml vs.(26.33 ± 4.72) ml,94.23％(49/52) vs.71.15％ (37/52)] (P ＜ 0.05).Conclusion The effect of laparoscopy is superior to laparotomy on tubal pregnancy.

Objective:To study the number of micronucleus in exfoliated cells of oral mucosa before and after radiotherapy in the patients with head and neck tumor. Methods:30 patients with head and neck tumor 1-22 years after radiation, 30 patients with head and neck tumor at completion of radiation of 40-86 Gy and 30 healthy controls were included. The micronucleus in exfoliated cells of oral mucosa were investigated by smear examination and Feulgen and fastgreen staining.Results:The micronuleus (% of cells with micronuleus) in the exfoliated cells of oral mucosa in the healthy controls was 0.18?0.14, in the patients before radiotherapy 0.18?0.12, in the patients at completion of radiotherapy 0.73?0.35, in the patients 1-22 years after radiotherapy 0.20?0.17.Conclusions:Radiotherapy may increase the number of micronucleus and the increace is reversible after radiotherapy.

Objective To explore the effict of Jiegu-Qili tablet combined with intramedullary interlocking nails in the treatment of the fracture of tibia and fibula. Methods A total of 80 patients with fracture of tibia and fibula were selected, and were divided into two groups according to odd and even number of hospitalization. The surgery group (39 patients) was given intramedullary interlocking nails, the surgery and drug group (41 patients) was given Jiegu-Qili tablet combined with intramedullary interlocking nails. The perioperative parameters, the rate of fracture healing, knee scores and complications were evaluated during 12 months. Results The hospitalization (14.43 ± 2.47 d vs. 21.63 ± 3.16 d, t=11.385, P<0.01) and fracture healing time (5.22 ± 1.05 m vs. 9.75 ± 0.97 m, t=20.016, P<0.05) of the surgery and drug group was shorter than that of the surgery group. The fracture healing rate of surgery and drug group (92.7%vs. 76.9%,χ2=3.894, P<0.05) was higher than that of the surgery group. After 6 months surgery, the pain, activity, stability and KSS scores (21.60 ± 1.60 vs. 19.50 ± 1.90, 22.7 ± 2.8 vs.18.70 ± 2.40, 23.50 ± 2.40 vs. 19.40 ± 1.80, 89.20 ± 9.30 vs. 78.00 ± 8.30) of the surgery and drug group were higher than that of the surgery group (P<0.05). There was no statistical significance on walking ability between two groups (21.40 ± 2.50 vs. 20.40 ± 2.20, P>0.05). During 12 months follow-up, there were no statistical significance on complications between two group (7.3%vs.15.4%,χ2=1.303, P>0.05). Conclusions In summary, the Jiegu-Qili tablet combined with intramedullary interlocking nails had a good therapeutic effect on the fracture of tibia and fibula. It could increase the speed of fracture healing, shorten the hospitalization, reduce the postoperative pain and improve the activity of patients.

AIM:In order to improve the clarity and quality of Ginkgo leaf water-extraction solution,and optimize the production process. METHODS:The experiment was based on the optical absoiption and scattering rate,flocculation rate and loss in flavanones were used as two main parameters to estimate the effect of influencing factors on flocculation.It could be proved by analyzing the particle size in water-extraction solution before and after flocculation. RESULTS:The best flocculation technological parameters of water-extraction solution of Ginkgo leaf with chitosan were as follows:at flocculant concentration of 1.071 g/L,flocculation temperature of 40(?C),pH of 4.9. CONCLUSION:The flocculation of water-extraction solution of Ginkgo leaf with chitosan is effective and selective,it has the advantage over ethanol precipitation method.

Objective To study the effect of resveratrol on hepatitis B virus (HBV) and hepatic fibrosis.Methods The rat model of HBV infection was established by intraperitoneal injection of rAAV8-1.3HBV.After successfully establishing the modle, were randomly divided into four groups:negative control group, resveratrol low dose group, high dose group, positive control group, and five rats in each group.Giving a physiological saline, 20 mg/kg respectively resveratrol, 40 mg/kg, 0.1 mg/kg acyclovir via gastrogavage respectively.2、4、8、12 weeks later ,we detected the HBsAg, HBeAg, HBV-DNA via tail vein blooding.HSC-T6 cell model was established.Then rats were divided into two groups, control and resveratrol serum group.Each group was administrated with normal sodium and resveratrol via gastrogavage to make serum.The HSC-T6 viability was observed by AlamarBlue assay.The expression of Col I and TGP-β1 mRNA was determined by Realtime PCR.The expressions of Col I and TGP-β1 Protein was analyzed by WesternBlot.Results Using ELISA method to detect HBsAg、HBeAg、HBV-DNA and found that the expression of HBsAg and HBeAg of negative control group were significantly higher than the rest of the three groups (P<0.05) at the second and the fourth week.The highest expression of HBsAg and HBeAg were (4118 ±367) IU/mL、(160.2 ±56.90) NCU/mL at the second week.The expression of HBV-DNA of negative control group is significantly higher than the rest of the three groups (P<0.05) at the second week.AlamarBlue assay indicated that different concentration of serum of resveratrol can inhibit HSC-T6 proliferation.Compared with control group, serum with drug resveratrol significantly down-regulated the mRNA and protein expression of Col I and TGP-β1.Conclusion Resveratrol inhibits HBV and liver fibrosis by inhibiting type I collagen and TGF-β1.

Axillary osmidrosis may have a negative impact on the patient's normal life and social interaction , though it has no obvious harm to health .Such factors as gene , hormone and food are involved in the occurrence and severity of axillary osmidrosis .The pathogenesis mechanism remians unclear .This paper aims to review on the research progress of the pathogenesis mechanism and related factors of axillary osmidrosis in recent years .

The single or combined administration of Raltitrexed with other anticancer drugs have showed prospective curative effects on solid tumor .This paper reviews the current research situation of Raltitrexed against malignant tumor and explores the possibilities for the efficacy and mechanism in treatment of malignant tumor . Raltitrexed is one kind of effective anti cancer drugs and plays a more and more important role in solid tumor ther -apy.