Objective:To discuss the applied value of the ultrasonic light scattering imaging DOT technology in the diagnosis of early breast lumps. Methods: The data of 114 patients that were experted ultrasound imaging of light scattering and were with clear pathological diagnosis results were analyzed retrospectively in our department in three years. Diagnostic indicators (SDI), the mass of the total amount of hemoglobin (HBT), oxygen saturation (SO2), mass direction (Orien) form factor (Forml) and the posterior echo (Pecho) were recorded, and the diagnostic sensitivity, specificity, positive predictive value, negative predictive value, false negative rate and false positive rate were analyzed. The results were proceed and analyzed through SPSS 17.0. Results:There were significant differences in the SDI, HBT, Orien, Forml(t=-4.122,t=-2.275,t=-2.206,t=-2.927,P<0.05)The diagnostic sensitivity was 95.7%, specificity was 95.5%, positive predictive value was 93.8%, negative predictive value was 97.0%,false negative rate was 4.3%and false positive rate was 4.5%. Conclusion: Light scattering of ultrasound imaging use SDI, HBT, Orien, the Forml four quantitative indicators, qualitative evaluation can reach the masses, has a higher value in the differential diagnosis.

Objective To compare prognosis of esophageal cancer patients with simple radiation or chemoradiotherapy.Methods Retrospective analysis 266 cases of esophageal cancer patients from June 2005 to June 2007 of,including 128 with simple radiotherapy,138 with chemotherapy during the same period,157 cases of general radiotherapy,intensity-modulated radiotherapy,109 cases of Kaplan-Meier method for calculation of survival,Log-Rank method on the clinical factors of single factor analysis,Cox regression model with factor analysis.Two groups,clinical material and adverse reaction were compared with chi-square test.Results The median survival time of the radiation group was 25 months,chemoradiotherapy group of the median survival time was 28 months.Follow-up with 1,3,5 years were 231,106,82 cases.The 1,3,4 years OS rate were 86.8 ％ (200/231),12.8 ％ (14/106),9.0 ％ (7/82).Disease-free survival (DFS) rates were 39.8 ％ (92/231),7.9 ％ (8/106),15.8 ％ (13/82).No local relapse survival (LRFS) rates were 30.8 ％ (71/231),16.2 ％ (17/106),23.7 ％ (19/82).No distant metastasis (DMFS) survival rates were 47.0 ％ (109/231),11.3 ％ (12/106),13.9 ％ (11/82).Single factor analysis results show that age,disease length,X-ray parting,different radiation method were 5 years OS independent prognostic factors.Age,disease length were DFS independent prognostic factors.Lesion length,different radiation method were LRFS independent prognostic factors for survival,lesion length and X-ray parting were without distant metastases independent prognostic factors for survival.Multiple factors analysis results showed that age,disease length,pathological type were 5 years OS related factors,and age,disease length,different treatment methods were DFS related factors,only lesions length was DMFS related factors,lesion length,different chemotherapy method was DMFS related factors of survival.The rate of serious adverse reaction of the chemoradiotherapy group was higher than radiotherapy group,the difference had statistical significance.Conclusion The chemoradiotherapy increase DFS rate,and at the same time,the incidence of adverse reaction also increases,but 5 years OS rate doesn't increased obviously.

Objective: To analyze the surveillance results of common diseases among primary and middle school students in Xinjiang Production and Construction Corps in 2020, so as to provide the evidence for formulating the control measures for common diseases among primary and middle school students. Methods: The comprehensive health surveillance data of 31 467 primary and middle school students were collected from 132 schools in 14 divisions of Xinjiang Production and Construction Corps in 2020, and the prevalence of poor vision, overweight and obesity, dental caries, malnutrition and elevated blood pressure were descriptively analyzed. Results: The 31 467 students included 15 580 boys ( 49.51% ) and 15 887 girls ( 50.49% ). There were 19 632 students ( 62.39% ) from urban areas and 11 835 ( 37.61% ) from suburban areas, and there were 11 371 primary students ( 36.14% ), 11 169 junior high school students ( 35.49% ) and 8 927 high school students ( 28.37% ). The detection rates of poor vision, overweight and obesity, dental caries, elevated blood pressure, and malnutrition were 57.22%, 29.69%, 27.57%, 15.03%, and 4.81%, respectively. The detection rates of overweight and obesity ( 36.07% vs. 23.45%, P<0.05 ) and malnutrition ( 5.71% vs. 3.93%, P<0.05 ) were significantly higher, while the detection rates of poor vision ( 51.61% vs. 62.72%, P<0.05 ), dental caries ( 24.46% vs. 30.63%, P<0.05 ) and elevated blood pressure ( 14.61% vs. 15.43%, P<0.05 ) were significantly lower in boys than in girls. The detection rates of overweight and obesity ( 30.17% vs. 28.91%, P<0.05 ) and poor vision ( 61.55% vs. 50.04%, P<0.05 ) were significantly higher, while the prevalence rates of malnutrition ( 4.55% vs. 5.24%, P<0.05 ), dental caries ( 24.47% vs. 32.73%, P<0.05 ) and elevated blood pressure (14.66% vs. 15.63%, P<0.05) were significantly lower in students from urban areas than from suburban areas. In addition, the prevalence of malnutrition and poor vision appeared a tendency towards a rise, while the prevalence of overweight and obesity, dental caries and elevated blood pressure appeared a tendency towards a decline among primary and middle school students with the study period (P<0.05 ). Conclusions The prevalence of poor vision, overweight and obesity, and dental caries is relatively high among primary and middle school students in Xinjiang Production and Construction Corps, and comorbid overweight and obesity and malnutrition is found.

Objective:To analyze the 3D changes of pharyngeal airway in patients with skeletal Class Ⅲ malocclusion after rapid maxillary expansion(RME)and maxillary protraction.Methods:53 patients underwent orthodontic treatment with Hyrax palatal ex-panders and maxillary protraction.Cone-Beam computed tomography(CBCT)scan was taken before treatment(T0),after 1 6 d RME (T1 )and after about 5 month maxillary protraction(T2).Data were reconstructed into 3D model,sagittal and transversal measure-ments,cross sectional areas,volumes of the pharyngeal airway were computed.Results:After RME,the transversal measurements, cross sectional areas,volumes of nasal passage were increased(P <0.05).After maxillary protraction,the 4 nasopharyngeal measure-ments were increased(P <0.05).Conclusion:RME and maxillary protraction may increase pharyngonasal airway.

Objective To discuss the effects of silencing of iASPP gene on human bladder cancer cells. Methods RNAi silencing of iASPP gene in bladder cancer cell 5637 and T24 cells were used by lentiviral mediated interfering short hairpin RNAs. Cell proliferation was tested by MTT assay, and rate of colony was tested by colony formation assay. Cell cycles were tested by using fluorescence-activated cell sorting. Results Down-regulation of iASPP could inhibit the growth and proliferation of human bladder cancer cells (P＜0.05). iASPP know-down could decrease the colony formation of 5637 and T24 cells (P＜0, 05). Knocking down of iASPP in 5637 and T24 cells showed cell arrested at G1. Conclusions Silencing of iASPP gene could inhibit proliferation and colony formation of bladder cancer, iASPP might be an important target for gene therapy of bladder cancer.

Aim To investigate the protective effects of Aplysin on ethanol-induced oxidative damage in rat pri-mary hepatocytes. Methods Rat primary hepatocytes were obtained via the portal vein collagenaseⅣin situ perfusion technique followed by a Percoll density gradi-ent centrifuge. MTT test was used to determine the op-timum dose of Aplysin and ethanol, and detect the cell vitality in primary hepatocytes. Supernatants of primary hepatocytes were harvested to measure AST and LDH level, and the SOD, GSH-PX activities and MDA con-tent in primary hepatocytes were observed. Flow cy-tometry was used to detect the cell apoptosis rate. DNA damage in primary hepatocytes was detected by single-cell gel electrophoresis assay. The level of mitochon-drial membrane potential in primary hepatocytes was tested by fluorogenic probe JC-1 . The CYP2 E1 activity in primary hepatocytes was detected by colorimetry. The proteins of CYP2 E1 were detected by Western blot. Results 300 mmol·L-1 dose of ethanol and 30 mg·L-1 dose of Aplysin were the optimal dosages and were used in the subsequent experiments. Hepatocyte vitality was significantly increased in Aplysin group compared to that in ethanol group, and Aplysin inhibi-ted the release of AST and LDH(P<0. 05). For Apl-ysin treatment group, the activities of hepatocyte SOD and GSH were significantly increased, and MDA was markedly lowered as compared with those in ethanol group( P <0. 05 ) . Aplysin could alleviate hepatocyte apoptosis significantly, and hepatocyte DNA damage rates of Ⅱ ~Ⅲ level and Ⅳ level were significantly lowered in Aplysin treatment group as compared with those in ethanol group, and Aplysin had evident im-provement in alcohol induced mitochondria damage of hepatocyte. Primary hepatocyte activities and protein expression of CYP2 E1 were markedly lowered in Aply-sin treatment group as compared with those in ethanol group(P<0. 05). Conclusion Aplysin has protective effects on liver oxidative damage induced by alcohol of primary cultured rat hepatocytes by blocking CYP2 E1 activation, relieving oxidative stress, and sharpening the oxidation resistance ability.

Objective:To investigate the clinical application value of argon-helium knife cryoablation combined with radioactive seed implantation in the treatment of non-small cell lung cancer(NSCLC).Methods:A total of 117 patients with NSCLC admitted to Oncology Department of Fifth Affiliated Hospital of Zhengzhou University from January 2015 to January 2017 were included in our study.And they were divided into the combination group(n=63)treated with CT guided argon-helium knife cryoablation combined with radioactive 125I seeds implantation and the control group(n=54)treated only with argon-helium knife ablation.The changes of blood routine indexes, tumor markers, tumor ablation target volume and CT value were observed before and 1, 3, 6 months after treatment.Adverse reactions during treatment and the evaluation results of efficacy were compared between the two groups.Patients were followed up for 24 months to observe the recurrence and survival rates between the two groups. Results:In the combination group, seeds of(12.49±4.91)were implanted, and the X-ray exposure was(123.16±42.75)Gy.There was no significant difference in general clinical data between the two groups before treatment( P>0.05). At 1, 3 and 6 months after treatment, as compared with control group the combination group showed the significantly decreased platelet count( t=3.154, 3.586, 2.233, P=0.027、0.019、0.034), while, there was no significant difference in white blood cell count, red blood cell count and hemoglobin level between the two groups(all P>0.05). The levels of carcinoembryonic antigen(CEA), neuron-specific enolase(NSE)and tumor volume were significantly lower in combination group than in control group at 3 and 6 months after treatment( t3=3.142, 2.926 and 4.281, t6=4.094, 5.382 and 4.535, all P<0.05), showing significant improvements of illness.While, the above levels showed no significant differences at 1 month after treatment between two groups( t=1.065, 1.037, P=0.197, 0.255). At each monitoring time, the CT value of tumor target area showed a steady downward trend( P<0.05). During the treatment, the incidence of thrombocytopenia was higher in the combination group than in the control group(47.6% or 30/63 vs.24.1% or 13/54, χ2=6.935, P=0.008), while there were no significant differences in the incidence of postoperative fever, pneumothorax, myoglobinuria, pain, bleeding and nausea and vomiting between the two groups(all P>0.05). After 6 months of treatment, the remission rate was higher in the combination group(73.0% or 46/63)than in the control group(48.1% or 26/54). The survival time and relapse-free time of the combination group were longer than those of the control group[(21.81±4.31)months vs.(18.93±5.94)months, (20.48±5.76)months vs.(16.93±7.14)months, Log Rank χ2=8.229 and 9.656, P=0.004 and 0.002)]. Conclusions:Argon-helium knife Cryoablation combined with radioactive seed implantation can effectively control the local progression of NSCLC, reduce the risk of tumor recurrence, and has high safety.

Objective To discuss MRI characteristics of dysplastic gangliocytoma of the cerebellum.Methods MRI manifesta-tions of 13 cases with dysplastic gangliocytoma of the cerebellum verified by operation and pathology were analyzed retrospectively. Results All of 13 cases were located in the cerebellar hemisphere and vermis.The lesions presented striated pattern of iso-intensity signal and hypo-intensity signal on T1-weighted images.The sign of tiger stripes was the feature in dysplastic gangliocytoma on T2-weighted and FLAIR images.All of the tumors showed slightly striated enhancement after intravenous administration of contrast agent.The mass effects of dysplastic gangliocytoma of the cerebellum along with the forth ventricle and brain stem oppressed were seen in all cases.NAA was mildly reduced on magnetic resonance spectroscopy (MRS)in 7 cases of dysplastic gangliocytoma of the cerebellum.Conclusion There are distinctive manifestations in MRI images for dysplastic gangliocytoma of the cerebellum,which has crucial diagnostic value before operation.

Objective The application value of CTA for BA in interventional theray of lung cancer.Methods 15 patients with lung cancers including central type(13 cases)and peripheral type(2 cases) proven by pathology were analyzed prospectively.They were all examined with contrast enhanced.MDCT and the data were sent to the workstation and reconstructed with thin section multi-planar reformation(MPR),maximum intensity projection(MIP)and volume rendering(VR).Results All cases of central type lung cancer were supplied by the bronchial artery including two by the bronchial artery and intercostal artery,clearly demonstrated on the scans with the origin,branches and routes.One case of peripheral lung cancer was supplied by the bronchial artery and the other could not find the definite supplying artery.Conclusions CTA of BA for lung cancer can provide the accurate localization and other reference data for interventional therapy.

In order to improve the clinical outcomes and promote the development of enhanced recovery after surgery(ERAS),a full-time specialized role of nurse navigator(NN) was established in Department of Surgery in February,2016. Clinical pathway for ERAS was designed,and role functions,core competencies and responsibilities of NN were formulated. According to the functions and the working frame,NN connected and coordinated teamwork activities,monitored the implementation of ERAS during the overall process. After implementation,the NN had dealt with 10 unusual incidents,the execution efficiency of the 14(82.4%) measurements were 100%,1 measurement was 97%,2 measurements were 94.1%,and 33 patients and 42 medical staff thought highly of the NN. This practice effectively promoted the development of ERAS team and specialist nurse role in our hospital.