BACKGROUND: In the past, much attention was paid mainly to the body symptoms like focal neurological impairment in stroke, but the accompanied psychological symptoms were ignored easily.OBJECTIVE: To investigate the psychosocial factor in acute cerebrovascular disease and the mental state after the attack.DESIGN: Observational case-control study based on patients and healthy people.SETTING: A neurology department in a university hospital.PARTICIPANTS: Totally 55 patients with stroke hospitalized in Neurology Department of Hospital Affiliated to Medical College of Shaoxing Art and Science College and 35 healthy people taking physical examination from January 2001 to December 2003 in the hospital as controls.METHODS: Patients with acute cerebrovascular disease certified by CT/MR and people in control group took symptoms checklist-90(SCL-90) test within a month after attack.MAIN OUTCOME MEASURES: SCL-90 scores of the two groups.RESULTS: The condition of mental state in patients with acute cerebrovascular disease was worse than that in control group( P ＜ 0.01 ). There existed obvious physical and mental reaction. It was found in subsection analysis that the size and location of the focus had relationship with the degree of mental disorder after attack and it was easier to have mental disorder if the affection lied in left cerebral hemisphere.CONCLUSION: It is necessary to give psychological intervention in prevention and cure of acute cerebrovascular disease. Recognizing bad effect of stroke on psychoactivity may help to guide the treatment.

Two thousands six hundreds and forty-four patients of malignant tumors of the breast were diagnosed and treated in our hospital from 1956 to 1990. Twenty-one cases of them were diagnosed mammary sarcoma by pathology in 0. 8% in contcmporary malignant tumors of the breast. The axillary lymph nodes of 6 cases in this group are clinically enlarged in 28. 6%, all of them were proved benign through mieroscopie examination. The age of the patient of mammary sarcoma is younger than that of the patient of mammary careinoma in the group. The patient's age over forty-five years and more than one year course have a hetter prognosis. Mammary sarcoma metastasizes by blood stream or local infiltrate, rarely metastasizes to regional lymph nodes. Mammary sarcoma is treated by removal of the tumor and simple mastectomy. The value of radiotherapy will be futher explored by practice.

TP5 and CsA were injected-intraperitoneally into groups of experimental mice, and NS was used for the contral group. Herpes simplex keratitis models were made subsequently by inoculation of the virus on the cornea. On the 4～6th day after inoculation, slit lamp examination showed that the corneal epithelial and stromal lesions in the TP5 group were significantly more severe than those in the NS group, whereas the group of CsA manifested no such differences. Among the 3 groups of mice, no differences were evident in the formation of corneal neovascularization, which all peaked on the 8th day. The conjuctival and palpebral lesions in the TP5 and CsA groups were also more severe than in NS group. Therefore, immunomodulators should be clinically used with care in accordance with the morbid varieties and conditions.

Pseudomonas aeruginosa was inoculated into corneal stroma of rabbits and the model of keratoconjunc tivitis was established. Empty liposomes were used in a control, group ofloxacin liposome and ofloxacin eyedrop groups as experimental ones. After treatment for six times conjunctival and corneal lesions were examinated. Swabs of conjunctival sac were cultured. Result: in conjunctiva, lesions in the two experimental groups were all significantly less than those in the control group on the 6th, 8th and 11th day. Lesions in the ofloxacin liposomes group were also significantly less than those in the ofloxacin eyedrop group on the6th day. In cornea, lesions in the ofloxacin liposomes group were significantly less than those in the control group on the 6 th, 8th and 11th day. Lesions in the ofloxacin eyedrop group were significantly less than those the control group on the 11th day. In the result of bacterium culture, the culture's positive rate of two experimental gronqs and control group had significant differences on the 6th day. On the 11th day, the positive rate the ofloxacin liposome groups and ofloxacin eyedrop groups increased, and in the ofloxaein liposomes group had a less increase. Conclusion: ofloxacin liposomes and ofloxacin eyedrops were effective in treatments of pseudomonas keratoconjuntivitis in the rabbit model, the effects of ofloxacin liposomes were better than that of ofloxacin eyedrops.

AIM To investigate the effects of idazoxan on the viability and DNA integrity of clonal BRIN-BD11 cells. METHODS MTS reduction was used to check the viability of BRIN-BD11 cells. FACS cell cycle analysis was employed to determine the effects of idazoxan on DNA integrity of BRIN-BD11 cells. RESULTS ①Idazoxan markedly reduced the viability of BRIN-BD11 cells and resulted in DNA damage in time-and dose-dependent manner.②Genistein, 5-HT 1A antagonist NAN190 and PKG inhibitor-KT5823 had no protective effects against idazoxan-induced damage of BRIN-BD11 cells. CONCLUSION Idazoxan has cytotoxic effect and induces apoptosis of clonal pancreatic ?-cells.

Objective To explore the related factors that lead to unqualified urine and stool routine test specimens, and put forward effective solutions. Methods Urine samples and stool samples of 500 cases were selected, and the unqualified urine and stool samples were analyzed thoroughly. Results The unqualified rate of routine urine test group was 5%, and the unqualified rate of fecal routine test group was 6.40%. Urine and stool test samples are not qualified a total of 57 cases, including 3 cases (5.26%) the lack of application, 5 cases (8.77%) test sample does not comply with the inspection application list information, 37 cases (64.91%), 3 cases of insufficient sample (5.26%) samples were contaminated, 4 cases (7.01%) for overtime, 5 cases (8.77%) were insufficient and inconsistent information. Conclusion The urine and stool often caused by the unqualified situation in clinical diagnosis, have a great relationship with the reason was largely related to nursing staff before collecting urine and stool specimens of patients with lack of guidance, and the acquisition is completed with the after is not strictly in accordance with the relevant standards carefully check samples, in order to effectively improve the current situation, the hospital needs to be more reasonable and scientific to collect urine and feces samples were developed on the basis of this process, by strengthening the training of nursing staff to the sample qualified to provide the important guarantee.

Objective To compare the curative effects of laparoscopy and laparotomy on tubal pregnancy.Methods Hospital 104 cases of tubal pregnancy patients were randomly divided into the laparoscopic group,52 cases,52 cases of laparotomy group,the two groups were compared age,pregnancies,gestational mass size,blood HCG levels,surgery time,the amount of bleeding in surgery,tubal patency rate after one month.Results They had no significant difference between two groups on age,pregnancies,gestational mass size,blood HCG levels (P ＞ 0.05).And they had significant difference between two groups on surgery time,the amount of bleeding in surgery,tubal patency rate after one month [(40.33 ± 14.32) min vs.(85.67 ± 19.46) min,(5.67 ± 4.50) ml vs.(26.33 ± 4.72) ml,94.23％(49/52) vs.71.15％ (37/52)] (P ＜ 0.05).Conclusion The effect of laparoscopy is superior to laparotomy on tubal pregnancy.

To discuss the common failures of PHILIPS DR and KODAK DR7500, analyze the working principle and failure phenomenon of the device, and then propose the exclusion and problem-solving methods to prove the accuracy through practice. The paper also focused on the correct use of DR and how the equipment maintenance staff to do a good job of maintenance and preventive maintenance , reduce unexpected failures and prolong the equipment life, provide reference for counterparts involved in the DR maintenance

Objective To study the expression of MMP-9 in epatocellular carcinoma (HCC) and the relationship between its expression and clinical pathological characteristics.Methods Specimens taken from 67 fresh resected HCC and 16 normal liver tissues were selected.Tissue sections were stained by EnVisionTM immunohistochemistry with anti-MMP-9 monoclonal antibodies.The expression of MMP-9 in HCC and the relationship between its expression and clinical pathological characteristics were analyzed with x2test,t test and rank-sum test.Results The positive ratio of MMP-9 in HCC tissues was 58.21％,it was obviously higher than that of normal liver tissues (12.5％,x2 =10.80,P ＜ 0.01).The expression of MMP-9 in the metastatic HCC tissues was significantly higher than that in the non-metastatic HCC tissues (40.18 vs 26.38,P ＜0.01).Conclusions The positive ratio of MMP-9 expression revealed that the expression of MMP-9 increased obviously in the HCC,and that its expression in the metastatic HCC tissues significantly increased relative to the non-metastatic tissues.It suggests that MMP-9 might decompose and destroy the extracellular matrix and cell membrane around HCC cell surface,and then promote invasion and metastasis of HCC.

Objective To study the clinical efficacy of canalith reposition on benign paroxysmal positional vertigo(BPPV).Methods In the eighty patients with BPPV,the 45 cases with anterior semicircular canal were treated with Epley reposition method and the other 35 patients with the horizontal semicircular canal were treated with barbecue tumble method.The clinical efficacy was observed.Results The effective rate of the Epley reposition method for anterior semicircular canal patients was 95.5％ (43/45) and the effective rate of the barbecue tumble method for horizontal semicircular canal patients was 91.4％ (32/35).Conclusion The canalith reposition method treated with BPPV patients has high clinical efficacy,simple procedures,and no obvious adverse reactions.