BACKGROUND: In the past, much attention was paid mainly to the body symptoms like focal neurological impairment in stroke, but the accompanied psychological symptoms were ignored easily.OBJECTIVE: To investigate the psychosocial factor in acute cerebrovascular disease and the mental state after the attack.DESIGN: Observational case-control study based on patients and healthy people.SETTING: A neurology department in a university hospital.PARTICIPANTS: Totally 55 patients with stroke hospitalized in Neurology Department of Hospital Affiliated to Medical College of Shaoxing Art and Science College and 35 healthy people taking physical examination from January 2001 to December 2003 in the hospital as controls.METHODS: Patients with acute cerebrovascular disease certified by CT/MR and people in control group took symptoms checklist-90(SCL-90) test within a month after attack.MAIN OUTCOME MEASURES: SCL-90 scores of the two groups.RESULTS: The condition of mental state in patients with acute cerebrovascular disease was worse than that in control group( P ＜ 0.01 ). There existed obvious physical and mental reaction. It was found in subsection analysis that the size and location of the focus had relationship with the degree of mental disorder after attack and it was easier to have mental disorder if the affection lied in left cerebral hemisphere.CONCLUSION: It is necessary to give psychological intervention in prevention and cure of acute cerebrovascular disease. Recognizing bad effect of stroke on psychoactivity may help to guide the treatment.

Objective To study the expression of MMP-9 in epatocellular carcinoma (HCC) and the relationship between its expression and clinical pathological characteristics.Methods Specimens taken from 67 fresh resected HCC and 16 normal liver tissues were selected.Tissue sections were stained by EnVisionTM immunohistochemistry with anti-MMP-9 monoclonal antibodies.The expression of MMP-9 in HCC and the relationship between its expression and clinical pathological characteristics were analyzed with x2test,t test and rank-sum test.Results The positive ratio of MMP-9 in HCC tissues was 58.21％,it was obviously higher than that of normal liver tissues (12.5％,x2 =10.80,P ＜ 0.01).The expression of MMP-9 in the metastatic HCC tissues was significantly higher than that in the non-metastatic HCC tissues (40.18 vs 26.38,P ＜0.01).Conclusions The positive ratio of MMP-9 expression revealed that the expression of MMP-9 increased obviously in the HCC,and that its expression in the metastatic HCC tissues significantly increased relative to the non-metastatic tissues.It suggests that MMP-9 might decompose and destroy the extracellular matrix and cell membrane around HCC cell surface,and then promote invasion and metastasis of HCC.

ObjectiveTo study the maternal diet on neonatal weight and gestational diabetes,placental function and the impact of it. Methods93 cases of maternal gestational diabetes admitted to hospital with informed consent according to odd and even numbers randomly divided to observation group(50 case) and control group(43 cases) ,all accept conventional treatment,including exercise,health education and drug,observation group plus with diet control,compare the two sets of maternal placental maturity,amniotic fluid situation and the situation of fetal weight. ResultsObservation group with normal weight was 38 cases(76.0％ ) ,low body weight was 9 cases( 18.0％ ) ,huge children was 3 cases(6.0％ ) ,control group was 27 cases( 62.8％ ) ,2 cases(4.7％ ), 14 cases( 32.6％ ) ,two groups of great children birth rate had no significant difference( x2 =9.210,P =0. 002) ;placental maturity between the two groups showed no significant differenee( x2 =1. 034,3. 353 and 0. 433,P =0. 307,0. 067and 0. 510). Observation group normal amniotic fluid was 42 cases(84.0％ ) ,oligohydranmios was 6 cases( 12.0％ ) ,polyhydramnios was 2 cases(4.0％ ) ,the control group was 28 cases(65.1％ ) ,3 cases(7.0％ ) ,12 cases(27.9％ ) ,normal amniotic fluid and polyhydranmnios were significant differences between the two groups ( x2 =4. 429,8. 548, P =0. 035,0. 003 ).ConclusionDiet can reduce fetal macrosomia and the incidence of oligohydramnios, and it could ensure the maternal and child safety.

Objective To study the clinical efficacy of canalith reposition on benign paroxysmal positional vertigo(BPPV).Methods In the eighty patients with BPPV,the 45 cases with anterior semicircular canal were treated with Epley reposition method and the other 35 patients with the horizontal semicircular canal were treated with barbecue tumble method.The clinical efficacy was observed.Results The effective rate of the Epley reposition method for anterior semicircular canal patients was 95.5％ (43/45) and the effective rate of the barbecue tumble method for horizontal semicircular canal patients was 91.4％ (32/35).Conclusion The canalith reposition method treated with BPPV patients has high clinical efficacy,simple procedures,and no obvious adverse reactions.

Objective To compare the curative effects of laparoscopy and laparotomy on tubal pregnancy.Methods Hospital 104 cases of tubal pregnancy patients were randomly divided into the laparoscopic group,52 cases,52 cases of laparotomy group,the two groups were compared age,pregnancies,gestational mass size,blood HCG levels,surgery time,the amount of bleeding in surgery,tubal patency rate after one month.Results They had no significant difference between two groups on age,pregnancies,gestational mass size,blood HCG levels (P ＞ 0.05).And they had significant difference between two groups on surgery time,the amount of bleeding in surgery,tubal patency rate after one month [(40.33 ± 14.32) min vs.(85.67 ± 19.46) min,(5.67 ± 4.50) ml vs.(26.33 ± 4.72) ml,94.23％(49/52) vs.71.15％ (37/52)] (P ＜ 0.05).Conclusion The effect of laparoscopy is superior to laparotomy on tubal pregnancy.

To discuss the common failures of PHILIPS DR and KODAK DR7500, analyze the working principle and failure phenomenon of the device, and then propose the exclusion and problem-solving methods to prove the accuracy through practice. The paper also focused on the correct use of DR and how the equipment maintenance staff to do a good job of maintenance and preventive maintenance , reduce unexpected failures and prolong the equipment life, provide reference for counterparts involved in the DR maintenance

Objective To investigate the effects of intensive insulin therapy on prognosis of patients with severe traumatic brain injury.Methods 130 patients with severe traumatic brain injury(GCS score 3-8) were randomly divided into the observation group (65 cases) and the control group (65 cases).The observation group received intensive insulin therapy,while the control group received conventional insulin therapy.The infection rate,hospital stay,in-hospital mortality and the 6-month mortality were observed.Results The infection rate of the observation group (32.4％) was significantly lower than that of the control group (46.7％) (x2 =1.946,P ＜ 0.05).The hospital stay of the observation group was significantly shorter than that of the control group (t =9.247,P ＜ 0.05).The inhospital mortality and the 6-month mortality were similar in the two groups(x2 =0.086,0.484,all P ＞ 0.05).The neurologic outcome according to Glasgow Outcome Score(GOS 4-5) at 6 months in the observation group was better than that in the control group(x2 =6.407,P ＜ 0.05).Conclusion Intensive insulin therapy can improve the prognosis of patients with severe traumatic brain injury.

Objective To evaluate the role of EP_2 in synaptic transmission in dentate gyrus of hippocampus. Methods Field excitatory post-synaptic potentials (fEPSP) were recorded at the perforated path-granule neurons in dentate gyrus in vitro. Results ① Butaprost, an agonist of EP_2, enhanced the synaptic transmission in dentate gyrus and decreased the paired-pulse ratio, and these effects were reversed by bath application of AH6809 (EP_2 antagonist). ② Application of Forskolin alone or with AH6809 elevated the slope of fEPSP. ③ The Butaprost-induced responses were mediated via PKA, ERK and IP_3 signal pathways. Conclusion Multiple signal pathways were involved in the EP_2 activation-mediated enhancement of synaptic transmission.

Objective To explore the role of cyclooxgense-2 (COX-2) in tetrahydrocannabinol (THC)-induced inhibition of long-term depression (LTD) in CA1 area in vitro. Methods The hippocampal slices were prepared at 24 h after intraperitoneal injection of Δ~9-THC (10 mg/kg) or COX-2 inhibitor NS398 (10 mg/kg). Field excitatory post-synaptic potentials (fEPSP) were recorded in the stratum radiatum of the CA1 area in vitro to observe the effect of NS398, a selective inhibitor of COX-2, on the THC-induced inhibition of LTD and THC's effect on membrane excitability in pyramidal neurons by using the whole-cell patch clamp technique. Results ① Low-frequency stimulation (1 Hz, 15 min) induced-LTD in CA1 area was significantly attenuated by Δ9-THC. ② Δ~9-THC did not affect the basal synaptic transmission and membrane excitability (including membrane resting potentials, input resistance and firing property). ③ THC-induced inhibition of LTD was reversed by NS398. ④ THC-induced inhibition of LTD was robustly impaired in COX-2 knockout mice. Conclusion THC-induced inhibition of LTD in CA1 area was mediated via COX-2.

Two thousands six hundreds and forty-four patients of malignant tumors of the breast were diagnosed and treated in our hospital from 1956 to 1990. Twenty-one cases of them were diagnosed mammary sarcoma by pathology in 0. 8% in contcmporary malignant tumors of the breast. The axillary lymph nodes of 6 cases in this group are clinically enlarged in 28. 6%, all of them were proved benign through mieroscopie examination. The age of the patient of mammary sarcoma is younger than that of the patient of mammary careinoma in the group. The patient's age over forty-five years and more than one year course have a hetter prognosis. Mammary sarcoma metastasizes by blood stream or local infiltrate, rarely metastasizes to regional lymph nodes. Mammary sarcoma is treated by removal of the tumor and simple mastectomy. The value of radiotherapy will be futher explored by practice.