Rheumatoid arthritis (RA) is an autoimmunity disease, and many effect factors contribute to the pathogenesis process of RA. Prostaglandin E_2(PGE_2) is one major inflammatory mediator. In this article ,we review the synthesis,metabolism and action pathway of PGE_2, the interaction between PGE_2 and inflammatory cellular factors of RA, and the therapeutic effect of drugs on RA.

Objective To investigate that whether the immuno-modulatory capacity is intact in myelodysplastic syndrome-refractory anemia (MDS-RA) derived mesenchymal stem cell (MSCs) and what are the differences compare with those from normal donors.Methods Isolating MSC from MDS and normal donors respectively and exam their differences on T lymphocyte activation,proliferation and suppression.Results The results showed that the capacity of suppressing T cell proliferation and activation is weakened.Conclusion We propose that MSCs from pathological environment might be abnormal and should not be used for autologous transplantation.

Objective To observe the effects of treating pulmonary infection of the aged people with the combination of TCM and WM.Methods A total of 120 the aged patients with pulmonary infection were randomly recruited into a control group and a treatment group,60 patients in each.The control group was treated with cefoperazone,sulbactam intravenously drop and inhalation of low flow oxygen(1～2L/min,2～4h,once/day),while the treatment group was added modified Xiaocaihu decoction and Shengmai injection on the basis of the control group.Both groups were treated for 14 days.Results The significant effective rate was 63.3%and 45.0%in the treatment group and the control group respectively,showing significant difference(U=0.5248,P<0.01).The effective rate was 96.7%and 83.3%in the treatment group and the control group respectively,also showing significant difference(U=0.5314,P<0.05).Conclusion It is effective to treat pulmonary infection of the aged patients with modified Xiaocaihu decoction and Shengmai decoction together with western medicine.

OBJECTIVE:To investigate the effect of sertraline on cytokine balance in patients with depression. METHODS: Serum levels of interleukin2(IL-2), interleukin12(IL-12), interleukin4(IL-4), tumor necrosis factor-alpha (TNF-?) and transforming growth factor beta (TGF-?1) were measured in 26 patients with depression(depression group) before and after treatment and 28 healthy volunteers (control group) by enzyme linked immunosorbent assay (ELISA). RESULTS: As compared with control group, in depression group the serum levels of IL-2, IL-12, TNF-? were significantly higher than in control group; the serum levels of IL-4, TGF-?1 were significantly lower than in control group(P

Objective To assess the efficacy of clinical intervention of early swallowing syndrome on neonates. Methods Eighty-six cases of normal newborns were enrolled in the study, including 44 cases of natural delivery,32 cases of cesarean section,8 cases of premature infant. The cases started vomitting before feeding the milk, became more severe after feeding the milk. once the pathological factors were excluded, the cases were treated with breastfeeding, warm water enema, massaging the lower abdomen, 1% sodium bicarbonate solution to the gastric lavage. Results A variety of clinical interventions on the control of neonatal swallowing syndrome results are obvious. Conclusions Early detection early intervention can prevent complications occurring.

OBJECTIVE To discuss the risk factors of nosocomial infection in burn patients in order to raise their treatment level.METHODS Picked out the nosocomial infection and the risk factors in burn patients during recent three years,we then made the review analysis.RESULTS From 234 cases 46 patients were with nosocomial infection,the infection rate was 19.66%,the most common location was wound infection,accounted for 63.04%,followed by respiratory tract for 23.91%.The main risk factors were age(≥ 60 years),severe degree burns,a long stay in hospital,and the large-scale application of antibiotics.CONCLUSIONS As for the high incidence of nosocomial infection among burn patients,we must pay close attention to and strengthen prevention.

Objective To investigate the diagnosis under hysteroscopy for uterine malformation,especially in maiden. Methods Hysteroscopy combined with ultrasonography was used to determine the types of uterine malformation in 24 cases. Results Definitive diagnosis indicated 8 cases of uterus bicornis,10 cases of uterus septus with single uterine neck,2 cases of uterus septus with double uterine neck and single uterine body,and 4 cases of puberal rudimentary horn of uterus. Conclusions Combined use of hysteroscopy and ultrasonography in the diagnosis of uterine malformation is accurate and applicable to maiden.

Objective To investigate the association between diet during pregnancy and hypertensive dis-order complicating pregnancy ( HDCP ) , so as to provide a theoretical basis guiding appropriate diet during pregnancy.Methods Using 1∶2 matched case-control study method, we selected pregnant women delivered in Anhui Women and Child Health Care Hospital from January to December 2014, and interviewed them with food frequency questionnaire.The relationship between intake frequency of various food and HDCP was analyzed. Results A total of 543 women were included in this study, including 181 cases and 362 controls.Mann-Whit-ney U test results showed that the frequencies of meat and fish, eggs, beans, nuts, milk, and pickled food con-sumption were significantly different between the cases and the controls (all P<0.05);while the differences in cereals, vegetables, and fruits consumption frequency between cases and controls were not statistically signifi-cant (all P>0.05).Multivariate Logistic regression analysis showed that higher intake frequencies of beans (OR=0.746, 95%CI:0.645-0.862), eggs (OR=0.789, 95%CI:0.693-0.898), and milk (OR=0.822, 95% CI:0.725-0.931) were associated with lower risk of HDCP; in contrast, higher intake fre-quency of pickled food was associated with higher risk of HDCP (OR=1.190, 95% CI:1.054-1.344). Conclusions Beans, eggs, and milk may be protective factors for HDCP, while pickled food may be risk fac-tor of HDCP.Diet during pregnancy should be appropriate and following scientific guidelines.

Objective To study the effect of multiple IPL treatment on cell senescence markers of skin fibroblasts using UVA as a control and to make clear whether the multiple IPL treatment may result in cell senescence.Methods Cells were divided into three groups: one group without irradiation as a control,one group receiving IPL treatment with 15 J per cm2,and the last group receiving UVA irradiation with 9 J per cm2.IPL and UVA irradiation were performed once a day during five days.On the sixth day,the cells were collected.Senescence-associated β-galactosidase (SA-β-Gal) staining,cell cycle,reactive oxygen species (ROS) and telomere length were determined.Results Our results showed that five consecutive days of IPL irradiation had no effect on the activity of SA-β-Gal and telomere length and decreased the G1 ％ of cell cycle and the level of ROS in comparison with the control group (P＜0.05).On the contrary,five consecutive days of UVA irradiation increased the activity of SA β Gal and the level of ROS,shortened the length of telomere and no obvious change in the G1 ％ of cell cycle in comparison with the control group.Conclusions Multiple UVA irradiations induce cell senescence.On the contrary,multiple IPL treatments could not induce cell senescence.

Objective: Our eyes are one of the most complicated physical organs. Many solutions have been put forward for hyperopia, myopia, aging eye and xenetnbole, which shows that great attention has been paid to illnesses related with cornea. Ophthalmic refractive surgery is one of the most advanced medical fields in ophthalmology, and laser treatment of myopia has been widely used around the world. With the matured myopia treatment, the treatment of hyperopia has increasingly become the focus of attention. However, there hasn't been the effective treatment of hyperemia, in particular, high hyperemia. Therefore, it is both academically and practically valuable to explore the laser treatment for hyperopia. Methods: In this paper, on the basis of Virtual Reality(VR) technology, a semiconductor laser thermal angioplasty framework for medical simulation system is established. In combination with the methods of object-oriented design and modular design, a simulation system is designed and developed. Results: The system performs the initial simulation functions of forecast, calculation and demonstration of semiconductor laser comeal thermal angioplasty in the treatment for hyperopia. Conclusion: The interactive simulation of the system modules can enable medical workers to experience and learn the actual surgical operations through the rehearsal process, and can also improve the modes, efficiency and quality of medical education and training, which has its practical value for the improvement of study of medicine. Corneal information database can help medical workers to facilitate clinical cornea information management With the deepening study, the functions can also be improved and with the increase in the data of the clinical cases and the improvement of the database, the forecast will be more accurate. The perfect interface for database、record and the property operation in the database have been developed in database management module of the system, which can easily manage and apply the comeal data.