Objective:To evaluate the safety and feasibility of root canal therapy in leukemia patients before bone marrow transplantation.Methods:15 root canal therapy of teeth with chronic periapical diseases were performed in 15 patients with leukemia before bone marrow transplantation.Diameters of the shaded area of periapex were all less than 0.5 cm.The root canal therapy was done at appropriate time,restricted hemateikon(neutrophil counts range from 3.0?109/L ~10?109/L,platelet counts more than 50?109/L),all the teeth were done with root canal therapy according to the principle of root canal therapy.All the patients were monitored by return visit after transplantation.Results:It did not happen any odontogenous complication with 15 patients during the bone marrow transplantation period.The periapical diseases of 15 teeth have been well controlled after root canal therapy.Conclusion:Teeth with chronic periapical diseases of patients with leukemia before bone marrow transplantation can be preserved after adequate root canal therapy and the root canal therapy is safe.

Objective:To study the effects of file tip size on the accuracy of Root ZX apex locator during electronic measurements in enlarged root canals.Methods: Forty premolars mounted in 20 g/L agar were used.First,the canals were instrumented using size 15-40 K-files with a size 40 as the master apical file(MAF).Second,the canals were enlarged using 45-60 K-files with the step-back way and 60 K-file as the MAF.In each step,the length was measured with a Root ZX using small and large tip size files.Results: File tip size and the degree of root canals enlarged both had a significant influence on the measurement,the difference was 0.22 mm.Conclusion: The measured working length with smaller size files become shorter when the root canals are enlarged.A file size comparable to the root canals should be used with root length measurement before root canal fillings.

Benzene ; poisoning ; China ; Chronic Disease ; Humans ; Occupational Diseases ; diagnosis ; Occupational Exposure ; adverse effects

Benzene ; poisoning ; Chronic Disease ; Humans ; Poisoning ; diagnosis

Acupuncture Points ; Acupuncture Therapy ; methods ; Adult ; Humans ; Male ; Varicocele ; therapy

Objective To investigate the effect of sanbai granules on the patients with leucoderma.Methods 180 cases with leucoderma were selected and divided into two groups.90 cases in the control group were treated by Methoxsalen Tablets 10mg,1 times a day,2h sunlight after the medication,appropriate amount external of Compound Kaliziran tincture and Halometasone.90 cases in the experiment group were treated on the base of the control group with Sanbai granules.The activity of tyrosinase,amount of melanin in the serum,clinical effect and amount of skin regeneration between two groups were compared.Results Compared with the control group, the activity of tyrosinase and melanin in serum of the experiment group were higher (P<0.05),the clinical effect rate were higher(P<0.05),number of skin regeneration piece was higher(P<0.05).Conclusion Sanbai granules can effectively improve the activity of tyrosinase and melanin in patients with leucoderma, and it has important significance for the treatment of leucoderma.

Intracoronary effects of calcitonin gene related peptide (CGRP) on coro-nary hemodynamics were observed in the normal and following different extent of coro-nary stenosis using graded coropary- stenosis modl in dogs. The results showed that CGRPincreased the coronary artery blood flow (CBF) and distant coronary blood prepsure (DCP),but decreased mean artery pressure (MAP), coronary vessels total resistance (R_T),large co-ronary vessels, resistance (R_L) and small coronary vessels resistance (R_s). Thirty minutesafter. coronary middle. stenosis, CGRP was given intracoronary, MAP had no significantchange, but CBF insreased and R_T R_L, R_s decreased, and which maintained for 30 min. 30min after coronary severe stenosis, CGRP increased CBF and MAP, but decreased DCP,R_T, R_L, R_S continuously. These results suggested that CGRP could ameliorate myocardialischemia through enlargement of coronary vessels and by increasing CBF.

Objective To detect the serum level of interleukin (IL)-1 1, lymphocyte subsets and NK cells in patients with idiopathic thrombocytopenic purpura (ITP), and explore the related factors in the pathogenesis of ITP. Methods The serum level of IL-11, lymphocyte subsets and NK cells were detected by double antibody sandwich enzyme linked immunosorbent assay (ELISA) and flow cytometry in 50 ITP patients (ITP group) and 30 controls (control group). Results The platelet in ITP group [ (30.21 ± 19.40) ×109/L] was lower than that in control group [ (207.21 ± 31.55 ) × 109/L] obviously (P ＜ 0.05 ); the serum level of IL-11 in ITP group [(255.72 ± 163.43) ng/L] was significantly higher than that in control group [ (40.60 ± 5.57 ) ng/L ] (P ＜ 0.05 ). The correlation analysis indicated that the blood serum levels of IL- 11 had negative relationship with the platelet (r = -0.557 ,P ＜ 0.05). The percentage of CD3+ and CD4+ T lymphocyte percentage, CD4+/CD8+ in ITP group were lower and the percentage of CD8+ T lymphocyte was higher than those in control group obviously (P ＜ 0.05 ). The percentage of CD3- CD(16+56) +NK cell in ITP group was lower than that in control group (P ＜ 0.05). Conclusion IL-11, lymphocyte subgroup and NK cell change correlate with ITP morbidity closely, and the IL-11 level and the platelet possibly have the negative feedback control action.

As we know more and more about asthma pathogenesis and chronic inflammatory disorder mechanism,and additional immunomodulator options become available.Studies have suggested that Th2 cell differentiation increases,and Th1 cell differentiation reduces in asthma.Therefore,it becomes an important immunotherapy method to modulate the Th1/Th2 response by promoting Th1 cytokines and inhibiting Th2 cytokines.At present,the use of immunomodulator such as anti-IgE antibody,anti-IL-5 agents,CpG oligodeoxynucleotides,imiquimod,bacterial extracts,Chinese medicine in asthma has already made some progress,and besidse it demonstrate great efficacy in clinical.