Breast cancer has become one of the most common malignant tumors in female and endangered their health seriously.In recent years,the incidence of breast cancer continues to be uptrend and tend to be younger.As the treatment of breast cancer is more diversified and meticulous,the prognosis of breast cancer has been improved.When Dr Csatary found a farmer got gastric cancer was cured by Newcastle disease virus occasionally,Newcastle disease virus was widely studied as a novel kind of anti-tumor biologics.So Newcastle disease virus had become an effective new treatment method in breast cancer.This article briefly elaborates the profile of Newcastle disease virus,mechanism,the significance of researching and other aspects.

Breast cancer was a common malignancy in female and endangered their health seriously.In recent years,the incidence of breast cancer has been more and more and younger and younger.With breast cancer checked out widely,the diagnosis rate of the early breast cancer has been significantly increased,so that the prognosis of patients with breast cancer has been apparently improved.Currently,the majority of patients did not only require removing the total tumor completely,but also ensuring tihe quality of life to reduce the psychological pressure.What's morc,they required a better cosmetic result.Thus the conventional treatments (such as surgery,radiotherapy,chemotherapy,estrogen and progesterone) have not met their pursuit; the radiofrequency ablation is a better therapeutic method.I briefly describe its principlcs,methods,status,postoperation,complication and so on.

0.05). In the field of side effects,especially EPS,weight gain,lactation and menstrual disorders,aripiprazole was significantly lower than risperidone(P

Objective:To analyze the application of antidepressants in our hospital in order to provide some reference for clinical rational drug use.Method:The antidepressants used in our hospital from 2006 to 2008 were classified by construction and mechanism and statistically analyzed in DDDs frequency.Result:Among the antidepressants used in our hospital,SSRIs were first-choice drugs,and venlafaxin of SNRIs dominated the first place in terms of use frequency and amount. Conclusion:Antidepressants used in our hospital were basically rational.

OBJECTIVE: To evaluate the therapeutic effects and cost-effectiveness of 3 therapeutic regimens in the treatment of gonarthritis. METHODS: The cost-effectiveness analyses were conducted among 3 therapeutic regimens: regimen A(sodium hyaluronate), regimen B(sodium hyaluronate plus compound betamethasone) and regimen C(sodium hyaluron_ate plus triamcinolone acetonide acetate). RESULTS: The total costs for Group A, B and C were 956.5 yuan, 1 206 yuan and 998.5 yuan, respectively. The effective rates were 79.2%, 91.3% and 96.4%, respectively. The cost-effectiveness ratios were 12.08, 13.21 and 10.36 respectively. As compared with regimen A, the incremental cost-effectiveness ratios for regimen B and C were 20.62 and 2.44 respectively. CONCLUSION: Regimen C is more preferable among the three therapeutic regimens.

ObjectiveTo investigate theeffect of combining traditionalChineseandWestern medicine therepy for patients with hormone-dependent dermatitis.Methods The relative literature conceming the clinical trials in treating patients with hormone-dependent dermatitis with therapy of combining traditional Chinese and Western medicine between 2005 and 2011 were retrieved,and Meta-analysis was made on the qualified literature by means of Review Manager 5.0 software.Results 15 randomized trials with 1749 patients met inclusion criteria.Compared with western medicine treatment group,the test results of the effective rate on the patients with hormone-dependent dermatitiswiththerapyof combining traditionalChineseandWestem medicinewasZ =12,P＜0.00001,OR =4.2 ( 95％ CI,3.32 t0 5.31).ConclusionPatients with hormone-dependent dermatitis with therapy of combining traditional Chinese and Western medicine could get better therapeutic effect.

Objective To observe the effects of solanine on DNA and RNA level in tumor cell of S_(180) and H_(22) tumor-bearing mice.Methods S_(180) and H_(22) mice were divided into solanine(37.50、18.75,and(9.37) mg/kg) groups,negative control group and cytoxan(30 mg/kg) group,whom were given drugs by sc.Levels of RNA and DNA in tumor cell membrane in every groups were examined,respectively by laser scanning confocal microtechnic technology.Results Solanine(37.50、18.75 mg/kg) groups reduced the ratio of RNA and DNA in tumor cell of both S_(180) and H_(22) mice.Conclusion Solanine can reduce the ratio of RNA and DNA in tumor cell of S_(180) and H_(22) mice,which may be one of the mechanisms of solanine's(antitumor) effect.

Objective To investigate whether black cohosh could be improve patients with breast cancer treated chemotherapy like-menopausal symptoms through a non-estrogen pathway.Methods We selected 120 patients with breast cancer dianosised and treated chemotherapy from January 2012 to June 2013 in four Affiliated Hospital of Harbin Medical,which were female patients,20-51 years,preoperative menopause,menstrual regularly,postoperative chemotherapy timely and regularly,and Kupperman score ≥ 15 points.All patients were randomized,double-blind divided into two groups,the experimental group was treated with medication Li Fumin Black Cohosh Extract,40 mg once daily,the other one was treated with placebo,40mg once a day.After 12 weeks,all patients were checked by estrogen hormones,gynecological ultrasound,the ultrasound of the other breast,Kupperman score,Then we make an assessment with those.Results During the experimental group and the control group,estrogen and endometrial thickness were within normal range,and there are not statistically significant difference between before and after medicine(P ＞ 0.05).What's more,before and after medication,the experimental group and the control group were not found new breast lumps.After taking medicine,the Kupperman score of experimental group was significantly lower than before treatment,the difference was statistically significant (P ＜0.05); however,there was not statistically significant difference between before and after medicine for the Kupperman score in control group(P ＞ 0.05).In experimental group,there are 5 cases of patients,which Kupperman is more 15 points,but lower than the score before taking medicine.Conclusions Black cohosh could improve like-menopausal symptoms of patients with breast cancer treated chemotherapy through a non-estrogen pathway,regardless of estrogen-receptor positive or negative,which has a good effection.

Objective To investigate the clinical significance of serum omentin-1 levels in obesity and essential hypertension patients and its related influencing factors. Methods One hundred and thirty patients with obesity admitted to the Cadre Health Care Department of Navy General Hospital from Jun. 2011 to Dec. 2013 were enrolled in this study. According to the blood pressure,130 obesity patients were divided into simple obesity group( n=64 )and obesity hypertension group( n=66 ). Sixty non obesity patients with normal blood pressure were enrolled as control group. Serum omentin-1 levels were assessed by enzyme linked immunosorbent assay ( ELISA). Association between omentin-1 and biochemical parameters( including systolic blood pressure( SBP), diastolic blood pressure(DBP),body mass index(BMI),waist hip ratio(WHR),fasting blood glucose(FBG), triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol( HDL-C),fasting insulin( FINS),insulin resistance index( HOMA-IR)and high sensitive C reactive protein(hs-CRP))were analyzed. Results Serum omentin-1 levels in control group was(26. 7 ± 5. 1)μg/L, significantly higher than that in simple obesity group and obesity hypertension group((22. 1 ± 3. 2)μg/L,(18. 3 ± 3. 4)μg/L;F=33. 7,P﹤0. 01),and serum omentin-1 levels in obesity hypertension group was significantly lower than that in simple obesity group( t =21. 5,P ﹤0. 05). Pearson correlation analysis showed that serum omentin-1 negatively correlated with BMI,WHR,SBP and HOMA-IR( r = - 0. 447,- 0. 340,- 0. 350,-0. 397;P﹤0. 01). There were no significant relations between omentin-1 and age,DBP,FBG,FBG,TG,TC, LDL-C,HDL-C,FINS and hs-CRP( P ﹥0. 05 ). Multiple stepwise regression analysis showed that HOMA-IR, BMI and SBP were independent influencing factors of serum Omentin-1. Conclusion The serum omentin-1 level decreases in the obesity hypertension patients. Omentin-1 is negatively correlated with BMI,SBP,and HOMA-IR, which may contribute to the underlying pathophysiology of obesity and essential hypertension.

The theory of Constructivism was applied in different aspects of clinical teaching of surgery.The lessons were designed according to the character of students.Problem solving was emphasized during the course of teaching.An interactive and cooperative atmosphere was constructed.And a variety of additional related materials were provided.All these measures made the teaching activity more accord with the objective rule of clinical knowledge learning.Hence a better teaching effect was achieved.