Objective To investigate the application effect of the fast-track surgery in rectal cancer surgery.Methods 90 patients wnderwent rectal cancer surgery were randomly divided into two groups,45 cases treated with conventional perioperative treatment were selected as the control group,45 cases with rapid rehabilitation of surgical techniques used in the perioperative treatment were seoected as the observation group.Results The first defecation time of the observation group (2.2 ± 0.5) d,for the first time the exhaust time was (1.5 ± 0.4) d,length of stay (6.2 ± 1.8) days,the cost of hospitalization (1.25 ± 0.21) million.The control group were (3.8 ± 0.6) d,(3.5 ±0.8) d,(9.2 ± 2.5) d,(1.98 ± 0.32) million,the difference were statistically significant (all P ＜ 0.05).1 patient (2.22％) had complications in the observation group,7 cases(15.56％) complications occurred in the control group,which was significantly higher than the observction group,the difference was statistically significant (P ＜0.05).Conclusion The rapid rehabilitation of surgical technique in rectal cancer can promote the rehabilitation of patients,reduce the incidence of complications,shorter hospital stay,lower medical costs.

Objective The trial was designed to observe the hemodynamic circadian rhythm in serious heart failure.Methods Totally 140 cases were assigned into the trial;120 cases of serious heart failure were into the heart failure group and 20 cases without heart failure into the control group.Heart rate(HR) and stroke volume(SV)were measured per hour during hospitalization.Results Circadian rhythm existed in two groups,but the heart rates were faster and the stroke stroke volumes lower in the heart failure group.As a whole,the HR and SV were positively correlative in two groups.But the cures of heart rate and stroke volume were separate between 1:00~4:00 before dawn in the heart failure group.The heart rate descended,while stroke volume rose.Conclusion There is divergence phenomenon between heart rate and stroke volume before dawn in serious heart failure.

Objective To observe the effects of Dl-3-n-butylphthalide ( NBP) on the mitochondria infarction, size of myocardial infarction and myocardial apoptosis after acute myocardial ischemia in rats. Methods 92 male SD rats were divided into sham operation group (8 rats) , model group (21 rats) , and low-dose NBP group (21 rats) , medium-dose NBP group (21 rats) , high-dose NBP group (21 rats) . The model and NBP groups were made into MI model by ligation of the left anterior descending ( LAD) coronary artery, but not in sham-operated group. Model group and NBP group were taken heart specimens after coronary artery ligation. Cardiomyocyte apoptosis was ana-lyzed by TUNEL in each group. Size of MI was analyzed by TTC staining in sham-operated group, model group and high-dose NBP group. Electron perspective microscopy was applicated in observing mitochondria infarction in model group and high-dose NBP group after myocardial infarction. The expressions of Bcl-2 protein and Bax protein were detected by Western blot. Results Compared with model group, butylphthalide significantly increased expression of Bcl-2 protein ( P <0.05 ) and the ratio of Bcl-2/Bax ( P <0.05 ) , inhibited mitochondria infarction ( P <0.05 ) , reduced myocardial infarct size ( P<0.01 ) and cardiomyocyte apoptosis ( P<0.05 ) . Conclusion Bu-tylphthalide significantly inhibits myocardial infarction by increasing expression of Bcl-2 protein and the ratio of Bcl-2/Bax and decreasing mitochondria infarction, reducing myocardial infarct size and cardiomyocyte apoptosis in rats during the acute myocardial ischemia process.

Objective:To investigate the common reasons for the failure of radical mastoidectomy in order to improve the result of treatment and obtain a dry ear.Method:Twenty-eight cases,who achieved no dry ear after radical mastoidectomy,underwent secondary surgery.Result:All cases obtained dry ear without vertigo or facial paralysis after operation and postoperative dressing.Conclusion:The reasons for the failure of radical mastoidectomy result from the incomplete clearance of lesions, the insufficient ventilation of mastoid cavities, the inappropriate postoperative dressings or the residual foreign bodies in surgical cavity.It is the key points to achieve skeletonization adequately, to eliminate the pathological tissues thoroughly under microscope, and to ensure unobstructed drainage of surgical cavities for preventing secondary surgery.

Background Isoliensinine(IL) is a kind monomer alkaloid of double benzyl group quinoline separated from Plumula nelumbinis,which has been speculated to have antiarrhythmic effect,Ca~(2+) and?1-receptor blockade, and reversal the left ventricular hypertrophy(LVH).It has been reported the activity of Sarco/Endoplasmic reticulum Ca~(2+)-ATP_(ase)(SERCA) in essential hypertention(EH)/LVH patients was lower than that of healthy people. Objective To investigate the effects of Isoliensinine on left ventricular hypertrophy and activity of SERCA in 2 kidney 1 clamp(2K1C) hypertensive rats.Methods 2K1C hypertensive rats were randomly received Isoliensinine (RHR-IL,5 mg/kg per day p.o,n=16) or placebo.Blood pressure,left ventricle mass index(LVMI) and the activity of myocardial SERCA were measured after 10 weeks treatment.Six untreated SD rats were served as control. Results Isoliensinine decreased BP and LV/BM ratio(IL:136.4?14.6 vs control:189.8?4.4 mm Hg,P

Objective To explore diagnosis capability of macular ganglion cell complex (mGCC)and peripapillary retinal nerve fiber layer(pRNFL) thickness for glancoma. Methods Adult outpatients received ocular regular examinations of glaucoma in our hospital were enrolled in this study. Parameters of pRNFL and mGCC measured by Fourier optic coherence tomography(OCT) were evaluated. Results 116 subjects ( 116 eyes) included 51 (44. 0% ) normal subjects, 30(30. 2% ) early glaucoma patients and 35 (25.9%) advanced glaucoma patients. There were significantly different pRNFL and mGCC thickness among the three groups ( F = 83.022,97. 361,27. 899,79. 585,140. 686,119. 166,116. 234, 90. 855,64. 341,133.064, P ＜0. 0l ). Area under Receive Operated Curve (AROC) of all pRNFL parameters in early glaucoma except nasal ( P ＞ 0. 05 ) and mGCC parameters had significantly diagnostic capability ( Need to be corrected by authors) ( pRNFL:0. 796 ±0. 049;mGCC:0. 748 ±0. 055, P ＜0. 05). As to the whole glaucoma, AROC of pRNFL and mGCC parameters had significantly diagnostic capability ( pRNFL:0. 889 ±0. 029; mGCC: 0. 862 ±0. 034, P ＜0. 01 ). Through AROC pairwise comparisons, the diagnosticpower of almost pRNFL and mGCC parameters had no difference ( P ＞ 0. 05) except that temporal, superior pRNFL thickness were significant higher than focal loss of volume (FLV) of mGCC ( P ＜ 0. 05 ). Conclusion The measurement of pRNFL thickness might still be used as a main method on diagnosis of glaucoma and mGCC could serve as a new beneficial complement tool for detection of glaucoma.

Objective To analyze the stroke subtypes and influencing factors in four largest economic regions of China.Methods We analyzed the investigation data of QUEST(Quality Evaluation of Stroke Care and Treatment)study conducted in 2006 which included 62 hospitals in a national scale.According to the concept of four economic regions designed by the Development Research Center of the State Council,we performed the univariate and multivariate analysis for the stroke subtypes and its related risk factors in the different economic regions.Results There were 3362(73.5％)ischemic stroke patients and 1214(26.5％)hemorrhagic stroke patients among the total 4576 first-ever stroke patients.Comparison of stroke subtypes in the four different economic regions was statistically significant(P ＜ 0.001),with a percentage of 80.8％ ischemic stroke patients in the northeastern region,78.9％ in the eastern region,68.3％ in the central region and 67.0％ in the western region.The comparisons of risk factors such as history of hypertension,diabetes,hyperlipidaemia,coronary artery event,atrial fibrillation,and overweight in the four different economic regions were also statistically significant(P ＜0.05).Conclusions The subtypes of first-ever stroke vary in the four largest economic regions with a highest proportion of ischemic stroke in the northeastern region and relatively high proportion of hemorrhagic stroke in the central and western economic regions.There are also discrepancies of stroke risk factors in the different economic regions.

Objective To study the effects of motor imagery therapy combined with electromyographic (EMG) biofeedback on upper limb function in hemiplegic patients.Methods Sixty hemiplegic stroke patients were recruited and divided into a control group (n=20),an electrical stimulation group (n=20) and a combination group (n=20).All groups received basic medication and routine rehabilitation training once daily for 4 weeks.The electrical stimulation group was also treated with EMG biofeedback,and the combination group with motor imagery therapy plus EMG biofeedback.The Fugl-Meyer assessment (FMA),the modified Barthel index (MBI) and EMG parameters were assessed before and after 2 courses of treatment.Results After 8 weeks of treatment all groups had significantly higher FMA scores and MBI scores,and better integrated EMG values,but the effects in the combination group were significantly better than those in the other two groups.Conclusions Motor imagery therapy combined with EMG biofeedback can more effectively promote recovery of upper limb function in hemiplegic stroke patients.

Objective To assess visibility of scleral spur in images of anterior chamber angle measured by the CAM model of Fourier optic coherence tomography (OCT). Methods Subjects aged 40 years or older were selected from outpatients in our opthalmologic clinic. All participants underwent standard ocular examinations, and anterior chamber angle was measured by CAM-L model of RTVue-OCT (Optovue Inc,USA) and gonioscopy. Visibility of scleral spur in OCT images and its related factor were analyzed. Results 98 subjects (98 eyes) aged (63.3±10.5)y included 62 females (63.3%) were selected in this study. There were 286 in 392 quadrants (73.0%) with visualized scleral spur, which had significant difference among local bulbar conjunctiva thickened or not (P＜0.01). Logistic multiple regression showed that the visibility of scleral spur was not associated with gender, age, gonioscope grades (P＞0.05), but significant associated with local bulbar conjunctiva thickened (OR＝0.113, P＜0.01) and quadrants (OR of superior/temporal＝0.210, OR of inferior/temporal＝0.340, P＜0.01), of which there were different scleral spur visibility in superior and inferior quadrants compared with temporal(OR＝0.210, 0.340, P＜0.01). Angle status was still identified in 80.2% quadrants on condition that scleral spur was not visualized. Conclusions Fourier optic coherence tomography has good feasibility to detect anterior chamber angle as an alternative method, and may supply helpful information to estimate the pathogenesis of angle closure glaucoma.

Objective To explore the effect of salvianolate combined with Qumei trimetazidine on cardiac function in patients with chronic heart failure.Methods Seventy-four patients with chronic heart failure were randomly divided into treatment group and control group (37 cases per group).Patients in control group were treated with the regular treatment scheme including digitalis,diuretics,vasodilators,angiotensin converting enzyme inhibitor(ACEI),angiotensin receptor blockers (ARB) or β blocker therapy for 24 weeks treatment.Patients in treatment group were given the regular treatment scheme plus salvianolic acid and Qumei trimetazidine treatment,of which,the dose of salvianolic was 0.2 g into 5％ glucose injection 250 ml or 0.9％ sodium chloride injection 250 ml by intravenous injection,1 times/day,and Qumei trimetazidine for 20 mg,3 times/day,for 24 weeks.Cardiac function was observed in patients of two groups before and after treatment.The level of brain natriuretic peptide (BNP) was measured.Results Heart function were improved,the total effective rate in treatment group was 91.9％ (34/37),higher than that of control group (70.3％ (26/37),x2 =5.638,P ＜ 0.05).In treatment group,left ventricular ejection fraction (LVEF),stroke volume (SV),cardiac output (CO) of patients after treatment were (52 ± 7) ％,(65.10 ± 12.87) ml,(5.65 ± 1.18) L/min respectively,significant different from that before treatment ((39 ±5)％,(46.53 ± 12.14) ml,(4.79 ± 1.02) L/min,and the differences were statistic significant (t =9.192,6.384,3.352,P ＜ 0.05).Meanwhile,in treatment group,systolic pressure,diastolic pressure,heart rate,left ventricular end diastolic diameter (Dd),left ventricular diastolic posterior wall thickness(PWT),interventricular septal thickness (IVST),left ventricular mass (LVMW),plasma brain natriuretic peptide of patients after treatment were (105 ± 8) mmHg,(75 ± 9) mmHg,(76±8) time/min,(48.7 ±3.7) mm,(9.1 ±1.4) mm,(8.7 ±1.2) mm,(170±59) g,(104.1 ±19.5) ng/L respectively,significant different from that of before treatment((134 ± 12) mmHg,(84 ±8) mmHg,(118 ±11) time/min,(55.2 ±7.8) mm,(11.7 ±2.3) mm,(10.5 ±2.4) mm,(228 ± 111) g,(568.7±179.5) ng/L t=-12.231,-4.546,-18.782,-4.579,-5.874,-4.080,-2.806,15.652,P ＜ 0.01).The same trend was seen in control group in terms of LVEF,SV,systolic blood pressure,heart rate,PWT,plasma BNP before and after treatment(LVEF:(38 ±6)％ vs.(43 ± 8)％ ;:(46.76 ± 11.80) ml vs.(58.69 ± 11.58) ml; systolic blood pressure:(132 ± 10) mmHg vs.(116 ± 11) mmHg; heart rate:(116 ± 10) time/min vs.(77 ±9) time/min;PWT:(11.5 ±2.6) mm vs.(10.4 ±2.0) mm;plasma BNP:(570.2 ± 177.3) ng/L vs.(211.6 ± 21.2) ng/L;t =3.041,4.389;-6.546,-17.632,-2.039,12.21 ;P ＜ 0.05 or P ＜ 0.01).Moreover,after treatment,systolic pressure,diastolic pressure,LVEF,SV,CO,Dd,PWT,IVST,LVMW,plasma brain natriureticpeptide in treatment group were significantly better than that of control grouo (t =-4.919,-2.867,5.510,2.252,2.581,-2.319,-3.238,-3.628,-2.231,-22.701,P ＜0.01 or P ＜ 0.05).Conclusion The effect of salvianolate combined Qumei trimetazidine on treating chronic heart failure is significant,and there is a reverse effect on the left ventricle.