Background Isoliensinine(IL) is a kind monomer alkaloid of double benzyl group quinoline separated from Plumula nelumbinis,which has been speculated to have antiarrhythmic effect,Ca~(2+) and?1-receptor blockade, and reversal the left ventricular hypertrophy(LVH).It has been reported the activity of Sarco/Endoplasmic reticulum Ca~(2+)-ATP_(ase)(SERCA) in essential hypertention(EH)/LVH patients was lower than that of healthy people. Objective To investigate the effects of Isoliensinine on left ventricular hypertrophy and activity of SERCA in 2 kidney 1 clamp(2K1C) hypertensive rats.Methods 2K1C hypertensive rats were randomly received Isoliensinine (RHR-IL,5 mg/kg per day p.o,n=16) or placebo.Blood pressure,left ventricle mass index(LVMI) and the activity of myocardial SERCA were measured after 10 weeks treatment.Six untreated SD rats were served as control. Results Isoliensinine decreased BP and LV/BM ratio(IL:136.4?14.6 vs control:189.8?4.4 mm Hg,P

Objective The trial was designed to observe the hemodynamic circadian rhythm in serious heart failure.Methods Totally 140 cases were assigned into the trial;120 cases of serious heart failure were into the heart failure group and 20 cases without heart failure into the control group.Heart rate(HR) and stroke volume(SV)were measured per hour during hospitalization.Results Circadian rhythm existed in two groups,but the heart rates were faster and the stroke stroke volumes lower in the heart failure group.As a whole,the HR and SV were positively correlative in two groups.But the cures of heart rate and stroke volume were separate between 1:00~4:00 before dawn in the heart failure group.The heart rate descended,while stroke volume rose.Conclusion There is divergence phenomenon between heart rate and stroke volume before dawn in serious heart failure.

OBJECTIVE:To seek for the countermeasures to standardize the administration of medical consultation service in the retail pharmacy.METHODS:To analyse the existing problems of the consultation service in the retail pharmacy.RESULT_S&CONCLUSION:We suggest that the consultation service should be carried out by speciallyassigned persons,CIS should be introduced,computer network should be manipulated and a standardized administration system should be established.Only in this way can the quality of service be raised and the security of medication of the public be ensured.

OBJECTIVE:To provide reference for Chinese pharmaceutical retail chain enterprises in making marketing strategy.METHODS:According to the organization and operational model of Chinese pharmaceutical retail chain enterprises,their practicable marketing strategy was discussed.RESULTS & CONCLUSION:Chinese pharmaceutical retail chain enterprises should make practicable and feasible marketing strategy to promote market competition ability basing on self-condition.

Objective To evaluate the hemodynamic changes induced by local infiltration with different concentrations of adrenaline during endoscopic sinus surgery under general anesthesia using impedance cardiography (ICG) .Methods Sixty-nine ASA Ⅰ or Ⅱpatients of both sexes (37 males, 32 females) aged 18-60 yrs undergoing elective endoscopic sinus surgery under general anesthesia were randomized to receive local infiltration of nasal mucous membrane with 4 ml of lidocaine containing 20 ?g (group Ⅰ) or 40?g (group Ⅱ) or no adrenaline (group Ⅲ-control) . Hemodynamic changes were monitored by ICG. MAR, HR, cardiac index (CI), systemic vascular resistance index (SVRI) and acceleration index (ACI) were recorded before (baseline) and at 0.75, 1.5, 2.25, 3.0, 3.75, 4.5, 5.25 and 6.0 min after local nasal adrenaline infiltration.Results MAP was significantly decreased while HR increased at 1.5 min after adrenaline infiltration as compared to the baseline values in group Ⅰ and Ⅱ (P

Objective To compare the therapeutic effects with different dosages of sertraline on patients suffering from idiopathic premature ejaculation. Methods IIEF-5 and CIPE questionnaires were completed before the treatment, and 86 patients who met the diagnostic standard of idiopathic premature ejaculation were finally recruited. Subjects were administered sertraline 50 mg/d combined with behavior therapy at stage Ⅰ for 4 weeks. Then, according to the therapeutic effects and the adverse events, all of the patients were divided into 3 groups for stage Ⅱ (another 4 weeks) as ①subjects with good effectiveness but with no or slight adverse events,would continue the treatments ②subjects with no therapeutic effects and with no obvious adverse events were allowed to increase the dosage of sertraline to 100 mg/d;③patients with effectiveness and obvious adverse events were al follows:lowed to reduce the dosage of sertraline to 25 mg/d. Those who had obvious adverse events and no effectiveness quit the study. Results During stage Ⅰ , 63 of 86 patients were effective (73.3%), and 23 patients had no improvement (26. 7%). Thirty-three patients had adverse events (38. 4%), and the remaining 53 patients had no obvious adverse events (61.6%). During stage Ⅱ , of the patients that responded to treatment, 35 patients who had no adverse events and 12 who had slight adverse events continued the treatment. Furthermore, 16 with intolerable adverse events were allowed to reduce the dosage to 25 mg/d. Meanwhile, of those without improvement, 18 subjects without obviousadverse events were allowed to increase the dosage to 100 mg/d, and 5 patients discontinued the treatment. Eight weeks later, among the patients taking 50 mg/d, 47 subjects were effectively with no obvious adverse events. Among the patients taking 25 mg/d, 10 showed improvement, 6 showed no improvement, and 2 had tolerable slight adverse events. Among the patients taking sertraline 100 mg/d,8 witnessed effectiveness, 13 had tolerable adverse events and 2 discontinued the treatment, with 1 having neither effectiveness nor obvious adverse events. The adverse events rate was 21.0% and the total effective rate of 8 weeks of treatment was 80.2 %. Conclusions Sertraline administration is an effective and safe way to treat idiopathic premature ejaculation. Although the effectiveness of the individualized treatment had no obvious improvement comparing routine therapy, there was a notable reduction in the adverse events rate, which increased the patient compliance.

Objective To investigate the therapeutic effect of total mesorectal excision(TME) for low rectal cancer.Methods One hundred nineteen patients with rectal cancer,located on an average within 8 cm of the anal verge,were included in the study.Fifty-four patients underwent traditional operation,and sixty-five patients underwent total mesorectal excision.Operation time,loss of blood at operation and local recurrence rates were compared between the two groups.Results The average operation time and blood loss were 118 minutes,and 100mL respectively in TME group,and they were 182 minutes,and 340 ml respectively in traditional operation group.There were significant differences between them(all P0.05).Conclusions In TME group,operation time was shorter,operative blood loss was less,and local recurrence rate was lower.TME should be applicated for patients with low rectal cancer.

Objective To evaluate the therapeutic effect,as well as the safety,of on-demand sildenafil on men with idiopathic ED.Methods One hundred and four men who met the diagnosis criteria of idiopathic ED were recruited into 2 groups.Among them,46 men who refused or were reluctant to take pharmacotherapy were recruited into the clinical control group with instruction of sexual knowledge and skills.Fifty-eight men who were involved in the on-demand group,were administrated sildenafil 50 mg just 1h before the coitus at thebeginning,then,if needed adjusted the dosage according to the effect and tolerance of the first four administration.The questionnaire of IIEF-5 was completed at the baseline and the end point,and the clinic total effective rate,the fully recovery rate of ED and the adverse events were also evaluated at the end of administration.Both groups were treated for 3 months.The therapeutic effect was reevaluated 1 month and 3 months later,respectively.Results After 3 months treatment,scores of IIEF-5 at the baseline and the end point for control group and on-demand group were as follow:5.2 and 12.6,4.2 and 19.8 ;and the fully recovery rate of ED for each group were as follow:12 (26.1％),56 (96.6％) ; the total effective rate for each group were 27.7％,97.2％ ; 1 month and 3 months after the end point,the fully recovery rate of ED and the total effective rate were evaluated separately,for 1 month:8 (17.4％),56(96.6％) and 19.4％,97.1％; for 3 months:7 (15.2％),55 (94.8％) and 16.4％,96.4％.The side effects in on-demand group (16,27.6％) was little higher than the control group (5,10.9％) (P ＞0.05).Most of the side effects were not only subtle and transient but also would vanish with the time.Accordingly,no one discontinued because of side effects.Conclusions Treatment of idiopathic ED with sildenafil was effective and safe.In terms of the fully recovery rate,total effective rate and effect maintenance,the on-demand group at the end point,even 1 month and 3 months after the end point,showed a great advantage over the control group.

Objective: To study the antixiodant activity of sweet-potato anthocyanin (SPAC) and its inhibiting effect on growth of cancer S180. Method: The scavenging capacity of ??O2 and?OH and the inhibitory effect of MDA were determined in vitro.The SOD activity of serum and skin, the effect on S180 growth, serum GSH-Px activity and MDA were tested in mice. Results: SPAC had antioxidant activity in vitro, with elimination rate of O2?? and?OH 30.63% and 20.57% higher than the same concerntration of VC respectively. Activity of SOD in the serum and skin of mice were raised 27.30% and 13.50% respectively after giving SPAC. The growth rate of cancer S180 in the mice was inhibited, and the highest inhibitory rate was 43.12%. The activity of serum GSH-Px, SOD of the mice was raised as compared to control, but MDA declined . Conclusion: SPAC is a perfect natural pigment with inhibitory effect on growth of cancer S180 probably through its antioxidant activity.