Objective To analyse the relationship between catechol-O-methyltransferase (COMT) activity and affective disorders, and explore the biological mechanism of the etiology of affective disorders.Methods The activities of erythrocytes COMT from 112 affective disorders and 120 normal control were measured with high performance liquid chromatography, all examined data were tested by SPSS 11.0v.Results COMT activity frequency distribution of patients group and control group are at the range of 2～23nmol/ml RBC/hr and 7～28nmol/ml RBC/hr respectively. The average activity of COMT in patients group and control group were (11.0±3.8) nmol/ml RBC/hr and (16.1±4.3) nmol/ml RBC/hr representatively. COMT activity in male and female patient were (11.2±3.7) nmol/ml RBC/hr and (10.6± 4.0) nmol/ml RBC/hr., male and female in control group were (16.5 ±4.6) nmol/ml RBC/hr and (15.4±3.9) nmol/ml RBC/hr, there were significant difference between patients group and control group and also between male and female (P <0.001).conclusion The activity of erythrocytes COMT in affective disorders is lower than normal population and suggested that the lower COMT activity of erythrocytes is associated with affective disorders.

Objective Cystic nephroma ( CN ) is an unusual benign neoplasm with high misdiagnosis rate , and at present there is no general method on its treatment .This study aimed to analyze the diagnosis and treatment of CN based on clinical data of CN patients. Methods We retrospectively analyzed the clinical data on 25 patients (including 2 cases of male pediatric patients , aged 14 and 16 years old, and the remaining 23 cases were adults, 11 males and 12 females, aged 14-69[45.1 ±19.6]years) treated in our department of the First Hospital of Shijiazhuang from January 2003 to July 2015 .All patients underwent ultrasound , CT and MRI examination , as well as surgical resection . Results Among these 25 CN patients , there were 15 cases of partial nephrectomy , 5 ca-ses of nephrectomy , 2 cases of retroperitoneal laparoscopic cyst unroofing , 1 case of laparoscopic enucleation of the tumors with nephron-sparing surgery , 1 case of laparoscopic radical nephroureterectomy , and 1 case of retroperitoneal laparoscopic radical nephrectomy .All the patients were successfully followed up for 6 months to 132 months, 1 patient recurred 6 months after retroperitoneal laparoscopic cyst unroo-fing and underwent open partial nephrectomy .No recurrence and me-tastasis were found in the remaining patients . Conclusion Imaging examination is an important measurement for CN , and intraoperative frozen pathology contributes to pathological diagnosis .Since most CN cases are benign , CN patients with no symptom or small cysts can take follow up survey .The principle of the operation is complete resection of the tumor , and nephron-sparing surgery is the first choice . In addition , regular follow-up is necessary in case of recurrence and malignant potential .