Objective According to the relevant literatures recorded in the CNKI bibliographic database from January 1994 to December 2007,research and application situation of exercise therapy have been investigated and analyzed.Methods Searched for"exercise therapy"in the MeSH and found 25,691 articles.In order to enhance the relevance of the literature search.limited"exercise therapy"being searched by"title search"and got 1102 articles.Results This article introduced the history and researching situation of exercise therapy,and made an investigation on the number of articles in the CNKI bibliographic database of previous 14 years and the number of articles on the top 10 diseases treated with exercise therapy.We found the largest amount of articles on exercise therapy was dealt with diabetic disease.Conclusion Exercise therapy can help to treat diseases caused by bad living habits.

Objective The morphological changes were observed in a pedigree with May-Hegglin anomaly cells.Methods Blood routine detection of abnormal May-Hegglin family members,peripheral blood cell Wright-Giemsa staining,and obser-vation of the white blood cell and platelet morphology.Made bone marrow smears of the proband,and megakaryocyte counts and classification.The proband peripheral blood leukocyte TEM examination were collected and analyzed by PCR sequen-cing.Results To reduce the May-Hegglin abnormal family blood platelet count in different degree,peripheral blood eosino-phil,eosinophilic inclusion visible form was not an alkaline cells,monocytes,neutrophils in body.Conclusion It’s provided valuable clues to diagnosis of morphological examination for May-Hegglin disorders.

Objective To Analyze the distribution characteristics of Hyperthyroidism's syndrome and the relationship between symptoms and thyroid hormones. Methods The TCM syndromes of a total of 78 patients with hyperthyroidism were differentiated. The relationship between syndrome and general condition of patients (gender and age, etc.) were analyzed;correlation between symptoms and thyroid hormones were also studied. Results Of all 78 patients, patients with yin deficiency and hyperactive yang accounted for 43.6%; patients with internal disturbance of phlegm-fire accounted for 30.8 %; and patients with hypteracitivity of heart-fire and liver-fire accounted for 25.6%. The severity of all the symptoms showed positive correlation with hyroid hormones (the value of r is positive, P＜0.05); and no linear relationship with TSH (P＞0.05).Conclusion The syndrome of yin deficiency and hyperactive yangI was the most common syndrome type. Thyroid hormones had direct proportion with the severity of syndrome.

This paper describes the relationship between standards and intellectual property rights,describes the importance of putting the intellectual property protection into the International standards of Chinese medicine by the examples.According to the Chinese medicine's own characteristics and actual conditions in our country,the author points out some suggestions on how to put the intellectual property protection into the International standards of Chinese medicine.

In this paper,we analyze the current situation of the national standardization on acupuncture needles and related patents.Through analyzing the international research focus on the acupuncture needle patents,we give some strategic suggestions on the intellectual property protection of acupuncture needles and traditional Chinese medicine.

The aim of this study was to investigate if there are abnormal fibroblasts derived from the skin surrounding keloids in order to have a better understanding for keloid progression. All the samples were used for cell culture. Flow cytometry was used to compare the apoptotic rate of fibroblasts derived from keloid and its surrounding skin, when it was cultured in serum-deprived medium for 24 hours or was induced by Fas antibody. After cultured in serum-deprived medium for 24 hours, the apoptotic rate of fibroblasts derived from the surrounding skin of keloid increased to an amount between that of normal skin and keloids. The apoptotic rate of normal skin fibroblasts increased more than that of keloids. Moreover, when induced by Fas antibody, the apoptotic rate of fibroblasts derived from the surrounding skin increased not so high as that of normal skin(P0. 05). Therefore, at least there are some fibroblasts in the surrounding skin of keloids, in which apoptosis can not be induced as in normal skin.

Objective To further discuss the characteristic of diabetic nephropahty,analyze its cause and pathogenesis,and make clear the relation between symptoms and syndrome,and to provide proof for prevention and therapy of this disease.Methods Records of 200 diabetic nephropathy patients treated clinically were collected and SPSS(Statistical Package for Social Science)12.0 was applied for analyzing.According to different conditions of the renal function,We divide the cases into two groups to study the relations between symptoms and syndrome.Results 1.The common symptoms of diabetic nephropathy are heavy body and drowsiness(74%),tired and debilitation(70%),and deficient breath and unwilling to speak(64%).2.The main syndromes of diabetic nephropathy are syndrome of deficiency of Qi、syndrome of yin asthenia,syndrome of dampness-heat blocking in the middle,and syndrome of blood stasis.Conclusion According to the research,the highest frequent appearing syndromes of deficiency were syndrome of Qi deficiency and syndrome of Yin deficiency,while the syndrome of dampness-heat blocking in the middle ranked No.1 in sthema syndromes and then caine the syndrome of blood stasis.However,the syndrome of blood stasis was the most severe,and this syndrome existed from the beginning to the end of this disease.

From the perspective of efficacy evaluation based on the literatures of MEDLINE database,the study carries out a bibliometrics study on domestic and foreign acupuncture clinical trials of the past three decades.The study involves the statistical classification on different systems and diseases,as well as statistics of diseases species on RCT or non- RCT involved,which will provide ideas and directions on diseases selection for the efficacy evaluation and re-evaluation researches in the field of evidence based medicine.

Objective To explore more effective treatments of Chinese medicine for diabetic nephropathy.Methods This study took opened non-relevant documents knowledge discovery method to study the diabetic nephropathy literatures in order to find the hidden links among literatures. A valuable scientific hypothesis will be put forward upon the study to guide or implement a new knowledge discovery after it acquire the agreement of experts. Results Use keywords frequency statistics method based on open non-related literature knowledge discovery, the anti-inflammatory herbs were filtered out Most herbs with anti-inflammatory effects had the functions of clearing away heat and detoxicating, expelling wind and removing dampness. Conclusion Prescriptions with the functions of clearing away heat and detoxicating, expelling wind and removing dampness may delay the occurrence and development of diabetic nephropathy and play an important role in curing this disease.

BACKGROUND:Keloid is the outcome of wound-healing process,and the result of massive accumulation of life-prolonged fibroblasts with gene mutation as well as the excessive synthesis of collagenous fibers.OBJECTIVE:To probe into the structural relations of exons 7-9 of fibroblastic Fas gene in keloid tissues.DESIGN:A self-controlled experimental study with cicatricial tissues as the subjects.SETTING:Department of Plastic Surgery of Southern Hospital of the First Military Medical University of Chinese PLA.PARTICIPANTS:This experiment was carried out at the Tropical Disease Research Institute of the First Military Medical University of Chinese PLA in 2001. All keloid and hypertrophic scar tissues were obtained from the patients who received orthopedic surgical operations at the Southern Hospital, including 15 patients with keloid and 12 patients with hypertrophic Scars. Normal skin and peripheral blood were obtained from the keloid patients as self-control. Meanwhile pathological tissues and normal skin and peripheral blood were obtained from patients with hypertrophic scars as normal control.INTERVENTION:PCR-single strand conformation polymorphism was used to find the structure of the exons 7-9 in Fas gene in15 patients with keloid.MAIN OUTCOME MEASURES:The structure of the exons 7-9 in Fas gene.RESULTS:Heterozygous loss of Fas gene exon-8 was observed in all the 15 keloid patients, and 20% of them displayed an increase in exon-9 allele band.CONCLUSION: The genetic structure of Fas gene showed no mutation in hypertrophic scars, normal skin and the peripheral blood,but mutations were detected in exons-8 ,and -9 of Fas gene in keloid. This was closely related with the disfunction of its encoded proteins.