Objective To explore the feasibility and effectiveness of gradient elastic compression stockings in prevention of venous stasis in patients undergoing laparoscopic cholecystectomy(LC). Methods 160 LC patients were randomized into the experimental group(75 cases)and the control group (85 cases).Routine nursing care and treatment were performed in both groups,and gradient elastic compression stockings were used in the experimental group.Venous pressure was measured in four different periods (T1,T2,T3,T4). Results The venous pressure in T2,T3 and T4 in the experimental group was significantly lower than that in the control group. Conclusions Use of gradient elastic compression stockings is effective and feasible in preventing LC-induced venous stasis.