1.Processing of the cerebellum in speech production by functional magnetic resonance imaging
Shengyong XIAO ; Hongchang ZHAI
Chinese Journal of Tissue Engineering Research 2008;12(48):9585-9588
BACKGROUND: The right hemisphere of the cerebellum was involved in linguistic function was disputed. In addition,there was no research report which suggested that the left hemisphere of the cerebellum participated in language processing as same as the right hemisphere. OBJECTIVE: To explore the activation of fight cerebellar hemisphere involved in speech production as well as to discuss the role of left cerebellar hemisphere in speech by means of examining the activated brain regions related the processing of speech production. DESIGN,TIME AND SETTING: Comparison observation,performed at Department of Magnetic Resonance,the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine between June and July 2008.PARTICIPANTS: Eight normal undergraduate with right-handed but without achromatopsia or hypochromatopsia volunteered to participate in the study. METHODS: Block design was used in this study. Subjects were required to generate a verb related to the Chinese 2-word noun represented visually and the functional scans were performed at the same time,and then the functional data were dealt with analysis of functional neuroimages (AFNI) and analyzed by drawing region of interest (ROI).MAIN OUTCOME MEASURES: The activation location,coordinate,voxel and the brain activation picture. RESULTS: Verb generation not only activated the right cerebellar hemisphere,but also the left cerebellar hemisphere.And the volumes activated in the left were larger than in the right. CONCLUSION: The lingual function of cerebellum is not only limited in the right,the left cerebellar,hemisphere may be engaged the processing of lingual function.
2.The Change Feature of the Signal of Fusiform before and after the Vocabulary Learning
Space Medicine & Medical Engineering 2006;0(06):-
Objective To explore the function of fusiform in learning process according to the change of its activation volume and intensity.Methods Ten Chinese normal university students with Guangdong dialect performed the verb generation.fMRI was used to scan the activities of brain.Deconvolution and ANOVA were used to deal with the data of individuals and groups respectively.Results After practice,the activations of the most brain areas were weakened in different degree of great quantities along with practice and the activation of fusiform disappeared.Conclusion Learning leads to the change of brain activation.The function of fusiform is not specific,but general neural activation during learning process.
3. Discordant lymphoma: report of one case and review of literature
Yunge GAO ; Shusen ZHAI ; Jihua WU ; Yan LEI ; Jiao GAO ; Tonghuan ZHEN ; Hongchang REN ; Heming YANG
Journal of Leukemia & Lymphoma 2019;28(11):672-675
Objective:
To investigate the clinical characteristics, diagnosis, treatment and prognosis of discordant lymphoma.
Methods:
The clinical data of one patient with discordant lymphoma at the PLA Strategic Support Force Characteristic Medical Center were retrospectively analyzed, and the related literatures were reviewed.
Results:
The patient was treated for thrombocytopenia and the examination showed splenomegaly. After hormone treatment, the platelet rebounded and thrombocytopenia occurred during hormone reduction. Splenectomy was performed. Postoperative pathological diagnosis of splenic marginal lymphoma was made and observed. Axillary lymph node enlargement occurred nine months later. Pathological diagnosis of diffuse large B-cell lymphoma was made by using lymph node biopsy, and the disease condition was alleviated after immunotherapy combined with chemotherapy.
Conclusions
Discordant lymphoma is rare and shows no special clinical manifestations. Its diagnosis should rely on pathological examination. Immunotherapy combined with chemotherapy may be more effective.