Objective:to study cognitive impairment of patients with Alzheimer disease (AD). Method:62 patients with AD and 159 normal elderly were tested with MMSE. Result:The patients group had lower scores in all subtests except that of naming. Level of education had positive correlation with the total score, subscores of attention and calculation, understanding, and describe graph. Conclusion:MMSE can be used in clinical assessment of cognitive function of patients with AD.

Objective To study changes of dielectric properties of gastrocnemius caused by simulated weightlessness.Methods Male Sprague-Dawley rats tail suspended for 10 wk were observed together with its normal control.AC impedance of isolated gastrocnemius was measured with an impedance analyzer(Agilent 4294A).Effects of simulated weightlessness on electric properties of cells in isolated rat sural muscle were also observed by analyzing the dielectric numerical characters of the dielectric spectra,the Cole-Cole plots,spectrum of loss factor and loss tangent,as well as spectrum of conductivity imaginary part.Results It was found that simulated weightlessness could induce certain changes:both relative permittivity at low frequency ?L and relative permittivity increment ??,as well as conductivity at high frequency ?h and conductivity increment ?? were all reduced.The first characteristic frequency fC1 decreased,while the second characteristic frequency fC2 increased.Peak of loss factor,peak of loss tangent and the maximum of conductivity imaginary part were also reduced.Conclusion Changes of dielectric property of gastrocnemius induced by simulated weightlessness can be observed effectively by frequency domain impedance technique.

Aim To study effects of morphine tolerance and dependence on the fast excitatory synaptic transmission in sympathetic ganglia of rats.Methods The isolated sympathetic ganglia,superior cervical ganglia(SCG), were made from control and morphine tolerant and dependent rats respectively.Effects of morphine tolerance and dependence on the fast excitatory synaptic transmission in rat sympathetic ganglia were studied by means of intracellular recording technique.Results ① Morphine(0.1～1.0 mmol?L~(-1))reversibly inhibited the amplitude of the fast excitatory postsynaptic potentials(f-EPSPs) in SCG neurons of control rats.② Compared with control group,inhibitory effects of morphine(0.5 mmol?L~(-1) and 1.0 mmol?L~(-1)) on f-EPSPs in SCG neurons of morphine tolerant and dependent rats were obviously decreased;③ Naloxone(0.1 mmol?L~(-1)),which had no significantly effect on f-EPSPs in SCG neurons of control rats,could reversibly facilitate the amplitude of f-EPSPs in SCG neurons of morphine tolerant and dependent rats;④ No significant difference of RMP and Rm was founded between SCG neurons of control and morphine tolerant and dependent rats.Conclusion The morphine tolerant and dependent of the fast excitatory synaptic transmission in rat sympathetic ganglia has been formed in morphine tolerant and dependent rats.

Aim To study the effects of chronic morphine treatment on the contents of cAMP and cGMP in sympathetic ganglia,superior cervical ganglia(SCG) of rats.Methods The chronic morphine dependent model of rats was established by subcutaneous injection of morphine in gradually increasing doses for 5 days,the dependence and the tolerance of the model was estimated by naloxone precipitation test and 55℃ tail-flick trail test respectively.The contents of cAMP and cGMP in SCG were detected by means of 125I radioimmunoassay.Results ① Compared with control group,the content of cAMP in SCG of morphine-acute group rats was descended(P0.05;compared with morphine-acute,P0.05).Conclusion There was an up-regulation of cAMP in sympathetic ganglia of chronic morphine treated rats.

Objective To investigate the clinical value of remote electronic fetal monitoring network in intrahepatic cholestasis of pregnancy(ICP). Methods Non-stress test (NST) was carried on in 54 cases of ICP by remote electronic fetal monitoring network(study group). Fifty-four cases of ICP served as control group were monitored by fetal movement counting daily and regular NST check-up in hospital. Abnormal NST and perinatal outcome were compared between the study group and control group. Results The incidence of abnormal NST was significantly higher in the study group than that in the control group ( 36.1% vs 27.2%, P 0.05). Conclusion Remote fetal monitoring network can be used to improve perinatal outcome of ICP. It is a new method of FHR self-monitoring for ICP case.

ObjectiveTo explore the efficacy and side-effects of reboxitine on post-schizophrenic depression.Methods30 patients with post-schizophrenic depression according CCMD-Ⅲ accepted reboxitine 4～8 mg/d in addition to antipsychotic drugs for 6 weeks. Efficacy and side-effects were determined with Hamilton Depression Scale (HAMD), Brief Psychiatric Rating Scale (BPRS), Scale for Assessment of Negative Symptoms (SANS), Treatment Emergent Symptom Scale (TESS) before and 2, 4, 6 weeks after treatment. ResultsThe score of HAMD were obviously improved after the treatment(P<0.01), as well as that of negative psychotic symptoms in BPRS and TESS. Slight symptoms that may be associated to the Reboxitine were obvioused seldom, and all recovered without any treating. ConclusionLow-dose rebositine is effective on post-schizophrenic depression with few side-effects and good compliance.

Homoacetogens are a group of microorganisms with application potential to produce chemicals and biofuels by the bioconversion of synthesis gas. In this study, we collected waste activated sludge samples to screen homoacetogens by Hungate anaerobic technique, and studied the effect of pH on acetate and alcohol production from H2/CO2 gas. The mixed culture contained Clostridium ljungdahlii, Lysinibacillus fusiformis and Bacillus cereus. Acetate concentration achieved 31.69 mmol/L when the initial pH was 7. The mixed culture containing homoacetogen could converting H2/CO2 to acetate, which provides an efficient microbial resource for the bioconversion of synthesis gas.
Acetates ; chemistry ; Bacteria ; classification ; Biofuels ; Carbon Dioxide ; Hydrogen ; Sewage ; microbiology

Objective The aim of the study is to discuss the application value of HA330-Ⅱ microporous resin plasma adsorption in liver support and the treatment of complications of chronic severe hepatitis.Methods The treatment group has 41 patients of chronic severe hepatitis B,which were treated for 3 times by HA330-Ⅱ microporous resin plasma adsorption.We compared the improvement of symptom,the fadeamay and rebound of icterus,the change of hepatic encepllalOpathy and brain oedema,the change of blood routine test,blood ammonia level,blood-gas analyzing result,cruor index,inflammatory factors(IL-1b,IL-6,IL-8,TNF-α,etc.),side effects,etc.The control group has 37 patients of the same type.Results HA330-Ⅱ microporous resin plasma adsorptioin is partly effective for the improvement of symptom,improvernent rate 43.9%,and without new discomfort due to the treatment. It obtains some extent fadeaway of icterus which has a low rebound,reduce TBiL(17.83±3.65)% and there be no statistics difference of rebound.It lowers the blood ammonia level and improves the hepatic encephalopathy and brain oedema.It absorbs cytokine IL-8.Atthough it has some extent effect to albunfin,blood paltelet,haemoglobin.Conclusion HA330-Ⅱ microporous resin plasma adsorption has good application value in the treatment of chronic severe hepatitis B.It is a new treatment choice of severe hepatitis.

BACKGROUND: Quite a number of in vitro experiments indicate that low dose He-Ne laser can stimulate the cell growth and blood vessel regeneration therefore to improve the damages caused by ischemia. However, it needs further study on the in vivo experiments.OBJECTIVE: To study the protective effects of intravascular low dose laser irradiation to ischemic reperfusion of rats and explore its mechanism.DESIGN: A randomised and controlled trial based on experinental animals.SETTING: Department of Neurology of a hospital of a university.MATERIALS: The experiment was completed in the Surgery Experimental Animal Center of West China Hospital of Sichuan University. Healthy male SD rats of class Ⅱ which aged between 5 to 6 months with weight of 372 to 418 grams[mean weight(388.48 ± 10. 57) g] were provided by Animal Research Center of Sichuan University.INTERVENTIONS: Middle cerebral artery ischemia model of rats was prepared. Forty SD rats were randomly divided into treatment group and control group with each of 20 rats. Intravascular low dose He-Ne laser irradiation was conducted to rats in treatment group one time every other day, 20 minutes per time and 3 times for a course. Vein puncture was conducted to rats in control group without laser input.MAIN OUTCOME MEASURES: Ratio of infarcted volume RESULTS: The ratio of the cerebral infarction volume in treatment group was (10.43 ± 1.04) and is much lower than that of control group(16.78 ± 1.12).There was statistical difference between two groups( t = 27.14, P ＜ 0.05).CONCLUSION: Intravascular low dose He-Ne laser irradiation has protective effects to cerebral ischemia of rats.

Shenzhen Eye Hospital took the lead to launch the time interval outpatient clinic appointment registration,for easing the difficulty of seeing doctors and shortening outpatient waiting time.With 30min as a registration interval,the hospital calls into play a variety of means to provide this service to outpatients.This service benefits the outpatients with comfortable hospital environment and promotes hospital efficiency.On this basis,the paper probed into existing problems in the appointment system and proposed improvement suggestions.