Objective To explore the relationship between the levels of serum BDNF,IL-6 and Hcy with cognitive impairment in the patients with first episode schizophrenia.Methods One hundred and thirty-five patients with schizophrenia(patients group)and 130 mental healthy volunteers (control group)in our hospital from January 2015 to January 2016 were selected as the research sub-jects.The levels of IL-6 and BDNF were detected by adopting the enzyme linked immunosorbent assay (ELISA)and Hcy level was detected by using the circulating enzymatic method.The mental symptoms were evaluated by the positive and negative symptom rat-ing scale (PANSS),cognitive function was evaluated by the Wisconsin Card Sorting Test (WCST)and their relationship was ana-lyzed.Results The BDNF level in the patients group was significantly lower than that in the control group,while the Hcy and IL-6 levels were significantly higher than those in the control group,the differences were statistically significant(P<0.05).The WCST errors response number,persistent errors number and total responses number in the patients group were significantly higher than those in the control group,while the complete classification number and correct response number were significantly lower than those in the control group,the differences were statistically significant (P<0.05).The levels of BDNF,IL-6 and Hcy had significant cor-relation with the WCST total responses number,persistent errors number,errors response number and complete classification num-ber.Conclusion The levels of serum Hcy,IL-6 and BDNF in the patients with first episode schizophrenia have a certain relation with the mental symptoms and cognitive function,which demonstrates the existence of nerve-humor-immune regulation network regulation mechanism in a certain degree and plays a synergic action in the occurrence and development of schizophrenia.

Comparative effectiveness research (CER) is well developed in international medical research. This article analyzes the basic connotations of CER from five aspects, including selection of objective, positioning of target population, comparison of intervention scheme, identification of contrast condition and analysis of therapeutic effects. The inclusiveness and advanced nature of CER were revealed by comparing with modern medical research methods, such as evidence-based medicine, patient-important outcome and randomized controlled trials. Based on the superiority of CER, the feasibility of applying CER in clinical evaluation of traditional Chinese medicine is explored. CER should be combined with the holistic concept, syndrome differentiation and individuality-concerned treatment so as to facilitate its development in research of traditional Chinese medicine in China.

Current situation and existed problems on bilingual teaching of molecular biology in medicine in our university were described in brief in present paper.According to actual teaching conditions of our university,and the developmental tendency on bilingual teaching in our state,some suggestions on promoting bilingual teaching of molecular biology in medicine,such as,bilingual teaching materials selection,course arrangement,teaching methods reformation,teachers training etc,were provided.

Objective To discuss the feature of the ultrasonic image and the clinical value of this test way.Methods six Cases of hypoplastie cartilage from 30 thousand fetus were detected.Results Shortened and widened long bone in four limbs,betl shape in chest,enlarged head and inflated abdomen are the main features of the ultrasonic image.Conclusion Ultrasound is superior to other methods in diagnosing fetus'hypoplastic cartilage.

Objective To explore the correlation between N-terminal pro-brain natriuretic peptide ( NT-porB-NP) and D-dimer in coronary artery disease patients with type 2 diabetes .Methods 50 coronary heart disease patients with type 2 diabetes were selected as the study group ,and 30 healthy subjects at the same period were select-ed as the healthy control group .The serum levels of NT-porBNP and D-dimer were detected in two groups ,and the cor-relation between NT-porBNP and D-dimer was analyzed .Results The serum D-dimer and NT-porBNP levels in the study group were significantly higher than those in the control group [(2.43 ±0.58)mg/L vs (0.26 ±0.13)mg/L, (1 487.8 ±201.5)pg/L vs (83.3 ±21.4)pg/L](t=21.34,32.12,all P<0.05).The D-dimer level was positively correlated with the NT-porBNP level (r=0.564,P<0.05).Conclusion In coronary heart disease patients with type 2 diabetes ,the serum levels of D-dimer and NT-proBNP are high and closely related .

Safety is a critical link restricting the development of TCM injections.Hospital centralized monitoring is of importance in the safety evaluation of TCM injections.However,the results of centralized monitoring studies usually deviated from the actual situation because of problems in design and process quality.Our research team have completed several projects over centralized monitoring in recent years.Based on the previous research experience,this paper mainly discussed the current statuation,the significance and methods for standard process of hospital centralized monitoring in regard to TCM injections,in order to improve the quality of centralized monitoring studies and provide technique support for recognizing the safety of TCM injections.

Objective To investigate the effects of chrysin(ChR) on the induction of differentiation and apoptosis-promoting of HepG 2 human primary hepatocacinoma cells. Methods The HepG 2 cells were cultured in vitro, and then treated with ChR and all-trans retinotic Acid (RA), respectively, the alterations of nucleocytoplasm and tubulin arrangement after Gimsa staining and Coomassie brilliant blue staining were observed. The survival rate and the inhibitory rates of HepG 2 cells were determine by trypan blue counting method and MTT assay. The Alpha-fetoprotein(AFP) secretory amounts of the cells were detected by radioimmunoassay(RIA). The activities of alkaline phosphatase(ALP) andγ-glutamyltranspeptidase(γ-GT) were assayed by enzymatic reaction kit. The synthesis of tyrosine-α-ketoglutaric acid transaminase(TAT) in cells were investigated by Diamondstone spectrophotometry. Results After treatment with ChR or RA at 1.0~100μmol/L for 48 h, the proliferation of HepG 2 cells were inhibited significantly, compared with vehicle group (P<0.05 or P<0.01), the inhibitory potency of both ChR and RA on HepG 2 cells was equivalent and indicated in dose-dependent manner. After treatment with 10μmol/L ChR or RA for 48 h, HepG 2 cells disaggregated and grew to spindle-shape, their nuclei became smaller and the number of nucleolus were fewer. Furthermore, tubulin arrangement of cells tended to be more ordered and the tubulin synthesis increased significantly. At 24~96 hours treated with 10μmol/L ChR, the activities of TAT and ALP in cells were all increased distinctly (P<0.05, P<0.01), and the secretory amounts of AFP and the specific activities ofγ-GT were decreased significantly (P<0.05, P<0.01). Conclusion Chrysin can inhibit the proliferation of HepG 2 cells and induce them to differentiate to mature cells.

According to the related requirements of safety reevaluation of TCM injections,hospital centralized monitoring of the safety of TCM injection was consecutively pressed ahead.Centralized security monitoring was a large-scale real world research involving numerous data acquisition,transmission,verification and analysis.The quality of data acquisition and data verification directly affected the authenticity and reliability of research data and results.Therefore,data management played a significant role in the safety monitoring of TCM injections.Based on the analysis of previous researches,this paper discussed the implementation content,links and the frequent problems and corresponding solutions of data management during the safety monitoring of TCM injections,combining with the experience in the implementation of projects.

The implementation process management plays a important role for the quality of centralized safety monitoring study of post-marketing Chinese medical injections.One of the critical link is hospital.Currently,there is no principle or specification for hospital choosing,number of monitoring points,data collection responsible part and forms of data collection as well.These issues caused uneven quality,huge differences in results and questioned conclusion.Based on the previous research experience,this paper focused on discussing the link of hospital where research data may be influenced,and proposed some suggestions.

We optimized the randomly combined specimens of limb bones into paired specimens of limb bones and used optimized (paired) specimens in systemic anatomy experimental teaching to strengthen the practical ability of medical students.Results showed that the teaching effect was better by using optimized (paired) specimens than by using randomly combined specimens.Applying optimized (paired) specimens was conducive to training students' practical ability and increasing the using efficiency of specimens.