Objective To analyze the incidence,risk factors,and impact of intraoperative conversion on the mortality in patients undergoing off-pump coronary artery bypass grafting.Methods This retrospective observational study included 207 patients undergoing off-pump coronary artery bypass grafting.According to whether intraoperative conversion,207 patients were randomly divided into intraoperative unchanged group(191 cases)and intraoperative changed group(16 cases).The incidence,patient characteristics,cause of intraoperative conversion,and its impact on outcome were studied.Results Intraoperative conversion increases odds for mortality to 25.0%,while the other group was 1.0%.The most common cause for intraoperative conversion was hemodynamic disturbances during grafting to the obtuse marginal artery.On multivariate logistic regression analysis,left main disease,mitral regurgitation and higher EuroSCORE II independently predicted intraoperative conversion.Conclusion Intraoperative conversion to on-pump coronary artery bypass grafting is independently associated with higher mortality in patients undergoing off-pump coronary artery bypass grafting.Identification of high risk group of intraoperative conversion may improve the outcome.

Objective To study and analyze the curative effect of linezolid in the treatment of severe pneumonia and the psychological countermeasures. Methods 100 cases of severe pneumonia patients treated in our hospital from March 2015 to August 2016 were selected and randomly divided into the control group and the experimental group. Two groups of patients according to the actual situation of patients with nutritional support and supplement electrolyte based treatment. The control group was treated with levofloxacin and ceftriaxone infusion treatment, the experimental group underwent intravenous linezolid therapy, and psychological care, pay attention to the psychological status of patients and patients, strengthen communication and exchanges, increase confidence in the treatment and the treatment compliance of patients. The therapeutic effects of the experimental group and the control group were compared and analyzed. Results After the corresponding treatment, the number of invalid cases in the experimental group was 4 cases, the number of effective cases was 31 cases, and the number of effective cases was 15 cases. The number of invalid cases in the control group was 10 cases, the effective number was 26 cases, and the effective cases were 14 cases. The effective rate of treatment in the experimental group was 92.0％, which was significantly higher than that in the control group, and the effective rate was 80.0％, with statistical difference (P<0.05). There were no obvious adverse reactions in the experimental group and the control group. The rate of adverse reactions in the control group was 14.0％, significantly higher than that in the experimental group (2.0％), and there was a statistical difference (P<0.05). Conclusion Linezolid is effective in the treatment of severe pneumonia, it can improve the therapeutic effect to a certain extent, and it has high security, it has the significance of clinical promotion.

Objective To explore the relationship of preoperative hemoglobin concentration and use of hospital resources.Methods 108 patients receiving cardiac surgery in the central hospital of wuhan were included.The relationship of preoperative hemoglobin concentration was explored on blood transfusion rates,return to the operating room for bleeding and/or cardiac tamponade,postoperative intensive care unit(ICU)and in-hospital length of stay,and mortality.Results For every 10-unit increase in hemoglobin(g/L),blood transfusion requirements were reduced by 8.0%,6.0%,and 3.0% for red blood cell units,platelet pools,and fresh frozen plasma units,respectively.For each 10-unit decrease in hemoglobin(g/L),the probability(over time)of discharge from the ICU and hospital increased 7.0%,16.0% respectively.Conclusion A lower preoperative hemoglobin concentration resulted in increased use of hospital resources after cardiac surgery.Therefore,the correction of decreasing preoperative hemoglobin concentration could improve the use of hospital resources after cardiac surgery.

Brain ; physiology ; Humans ; Magnetic Resonance Imaging ; Mastication ; physiology

Humans ; Nerve Growth Factor ; physiology ; Pain ; physiopathology ; Pulpitis ; physiopathology ; Receptor, Nerve Growth Factor ; physiology ; Receptor, trkA ; physiology

Humans ; Lung Neoplasms ; blood supply ; pathology ; Lymphatic Vessels ; pathology ; Neovascularization, Pathologic ; metabolism ; Vascular Endothelial Growth Factors ; chemistry ; metabolism ; physiology

Dental Porcelain ; classification ; Humans

0.05).Conclusions The serum MMP-9 can be tested as an objective index in appraisal the severity of the left to right shunt.The increased level of MMP-9 may be one of important mechanism for developing heart failure process in children with left to right shunt CHD.Monitor the level of MMP-9 will help us find adverse myocardial remodeling earlier and begin treatment immediately to prevent heart failure developing.

A variety of extra-cellular signals could activate the target molecules and induce the associated biological effects depended on different signal pathways. Apoptosis, or programmed cell death, is a conservation process essential for normal development and homeostasis of biologist. It's known that a number of factors and pathways can lead to apoptosis. Specific phosphorlipids and proteins of biomembrane could activate the signal cascades of apoptosis. The interaction of caspases, bcl-2 family and mitochondria play an essential role in regulation of apoptosis.

Objective to observe the efficacy and application value of PFNA and Gamma in the treatment of intertrochanteric fractures in elderly. Methods 100 patients with intertrochanteric fractures were divided into PFNA group and Gamma group, who received PFNA treatment and Gamma treatment respectively. And the operation status of patients at different ages,postoperative recovery,and complications were observed. Results The operation time,intraoperatve blood soss of PFNA group were lower than those of Gamma group(P<0. 05). There was no significant difference in fracture healing time. The Harris score of the over 75s in PFNA group was higher than that in Gamma group(P<0. 05),and the complications were less than Gamma group(P<0. 05). Conclusion PFNA was suitable for the patients at differ-ent ages with the advantages of more rigid fixation,good anti-rotation,fewer trauma and fewer complications.